This collection showcases the journal articles and other publications authored by researchers in the Craig Lab in the Department of Cell and Developmental Biology at the University of Massachusetts Medical School.

Submissions from 2014

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Structure, sarcomeric organization, and thin filament binding of cardiac myosin-binding protein-C, Roger Craig, Kyounghwan Lee, Ji Young Mun, Iratxe Torre, and Pradeep K. Luther (Pflugers Archiv : European journal of physiology)

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Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism, Ji Young Mun, Michael J. Previs, Hope Y. Yu, James Gulick, Larry S. Tobacman, Samantha Beck Previs, Jeffrey Robbins, David M. Warshaw, and Roger Craig (Proceedings of the National Academy of Sciences of the United States of America)

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Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state, Shixin Yang, Lucian Barbu-Tudoran, Marek Orzechowski, Roger Craig, John Trinick, Howard White, and William Lehman (Biophysical journal)

Submissions from 2013

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Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function, Brian Lin, Suresh Govindan, Kyounghwan Lee, Piming Zhao, Renzhi Han, K. Elisabeth Runte, Roger Craig, Bradley M. Palmer, and Sakthivel Sadayappan (PloS one)

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Different head environments in tarantula thick filaments support a cooperative activation process, Guidenn Sulbaran, Antonio Biasutto, Lorenzo Alamo, Claire Riggs, Antonio Pinto, Franklin Mendez, Roger Craig, and Raul Padron (Biophysical journal)

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Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implications, John L. Woodhead, Fa-Qing Zhao, and Roger Craig (Proceedings of the National Academy of Sciences of the United States of America)

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Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implications, John L. Woodhead, Fa-Qing Zhao, and Roger W. Craig (Proceedings of the National Academy of Sciences of the United States of America)

Submissions from 2012

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Isolation, electron microscopy and 3D reconstruction of invertebrate muscle myofilaments, Roger W. Craig (Methods (San Diego, Calif.))

Submissions from 2011

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Mechanism of the Ca(2)+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA, Sandip K. Badyal, Jaswir Basran, Nina Bhanji, Ju Hwan Kim, Alap P. Chavda, HyunSuk Jung, Roger W. Craig, Paul R. Elliott, Andrew F. Irvine, Igor L. Barsukov, Marina Kriajevska, and Clive R. Bagshaw (Journal of molecular biology)

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A molecular model of phosphorylation-based activation and potentiation of tarantula muscle thick filaments, Reicy Brito, Lorenzo Alamo, Ulf Lundberg, Jose R. Guerrero, Antonio Pinto, Guidenn Sulbaran, Mary Ann Gawinowicz, Roger W. Craig, and Raul Padron (Journal of molecular biology)

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Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry, Xiachuan Edward Li, Larry S. Tobacman, Ji Young Mun, Roger W. Craig, Stefan Fischer, and William Lehman (Biophysical journal)

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Modulation of striated muscle contraction by binding of myosin binding protein C to actin, Pradeep K. Luther and Roger W. Craig (Bioarchitecture)

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Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle, Pradeep K. Luther, Hanspeter Winkler, Kenneth Taylor, Maria E. Zoghbi, Roger W. Craig, Raul Padron, John M. Squire, and Jun Liu (Proceedings of the National Academy of Sciences of the United States of America)

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Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C), Ji Young Mun, James Gulick, Jeffrey Robbins, John L. Woodhead, William Lehman, and Roger W. Craig (Journal of molecular biology)

Submissions from 2010

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Electron microscopy and three-dimensional reconstruction of native thin filaments reveal species-specific differences in regulatory strand densities, Anthony Cammarato, Roger W. Craig, and William Lehman (Biochemical and biophysical research communications)

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The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments, Agnieszka Galinska, Victoria Hatch, Roger W. Craig, Anne M. Murphy, Jennifer E. Van Eyk, C. L. Albert Wang, William Lehman, and D. Brian Foster (Circulation research)

Submissions from 2009

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Tropomyosin and the steric mechanism of muscle regulation, William Lehman and Roger W. Craig (Advances in experimental medicine and biology)

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Structural basis for the activation of muscle contraction by troponin and tropomyosin, William Lehman, Agnieszka Galinska-Rakoczy, Victoria Hatch, Larry S. Tobacman, and Roger W. Craig (Journal of molecular biology)

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The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA, Nobuhisa Umeki, HyunSuk Jung, Shinya Watanabe, Tsuyoshi Sakai, Xiang-Dong Li, Reiko Ikebe, Roger W. Craig, and Mitsuo Ikebe (Proceedings of the National Academy of Sciences of the United States of America)

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Analysis of tarantula skeletal muscle protein sequences and identification of transcriptional isoforms, Jingui Zhu, Yongqiao Sun, Fa-Qing Zhao, Jun Hu, Roger W. Craig, and Songnian Hu (BMC genomics)

Submissions from 2008

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Three-dimensional reconstruction of tarantula myosin filaments suggests how phosphorylation may regulate myosin activity, Lorenzo Alamo, Willy Wriggers, Antonio Pinto, Fulvia Bartoli, Leiria Salazar, Fa-Qing Zhao, Roger W. Craig, and Raul Padron (Journal of molecular biology)

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Structural basis for the regulation of muscle contraction by troponin and tropomyosin, Agnieszka Galinska-Rakoczy, Patti Engel, Chen Xu, HyunSuk Jung, Roger W. Craig, Larry S. Tobacman, and William Lehman (Journal of molecular biology)

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Ca2+ -induced tropomyosin movement in scallop striated muscle thin filaments, HyunSuk Jung and Roger W. Craig (Journal of molecular biology)

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Head-head and head-tail interaction: a general mechanism for switching off myosin II activity in cells, HyunSuk Jung, Satoshi Komatsu, Mitsuo Ikebe, and Roger W. Craig (Molecular biology of the cell)

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The globular tail domain puts on the brake to stop the ATPase cycle of myosin Va, Xiang-Dong Li, HyunSuk Jung, Qizhi Wang, Reiko Ikebe, Roger W. Craig, and Mitsuo Ikebe (Proceedings of the National Academy of Sciences of the United States of America)

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Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle, Pradeep K. Luther, Pauline M. Bennett, Carlo Knupp, Roger W. Craig, Raul Padron, Samantha P. Harris, Jitendrakumar Patel, and Richard L. Moss (Journal of molecular biology)

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Millisecond time-resolved changes occurring in Ca2+-regulated myosin filaments upon relaxation, Fa-Qing Zhao and Roger W. Craig (Journal of molecular biology)

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Head-head interaction characterizes the relaxed state of Limulus muscle myosin filaments, Fa-Qing Zhao, Roger W. Craig, and John L. Woodhead (Journal of molecular biology)

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Blebbistatin stabilizes the helical order of myosin filaments by promoting the switch 2 closed state, Fa-Qing Zhao, Raul Padron, and Roger W. Craig (Biophysical journal)

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Three-dimensional structure of vertebrate cardiac muscle myosin filaments, Maria E. Zoghbi, John L. Woodhead, Richard L. Moss, and Roger W. Craig (Proceedings of the National Academy of Sciences of the United States of America)

Submissions from 2007

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Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development, Yingcai Wang, Danuta Szczesna-Cordary, Roger W. Craig, Zoraida Diaz-Perez, Georgianna Guzman, Todd Miller, and James D. Potter (The FASEB journal : official publication of the Federation of American Societies for Experimental Biology)

Submissions from 2006

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Structure and function of myosin filaments, Roger W. Craig and John L. Woodhead (Current opinion in structural biology)

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The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motor, Xiang-Dong Li, HyunSuk Jung, Katsuhide Mabuchi, Roger W. Craig, and Mitsuo Ikebe (The Journal of biological chemistry)

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An atomic model of the thin filament in the relaxed and Ca2+-activated states, Alnoor Pirani, Maia V. Vinogradova, Paul M. Curmi, William A. King, Robert J. Fletterick, Roger W. Craig, Larry S. Tobacman, Chen Xu, Victoria Hatch, and William Lehman (Journal of molecular biology)

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A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle, Katrina J.V. Poole, Michael Lorenz, Gwyndaf Evans, Gerd Rosenbaum, Alnoor Pirani, Roger W. Craig, Larry S. Tobacman, William Lehman, and Kenneth Holmes (Journal of structural biology)

Submissions from 2005

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E93K charge reversal on actin perturbs steric regulation of thin filaments, Anthony Cammarato, Roger W. Craig, John C. Sparrow, and William Lehman (Journal of molecular biology)

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Mini-thin filaments regulated by troponin-tropomyosin, Huiyu Gong, Victoria Hatch, Laith Ali, William Lehman, Roger W. Craig, and Larry S. Tobacman (Proceedings of the National Academy of Sciences of the United States of America)

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Single particle analysis of relaxed and activated muscle thin filaments, Alnoor Pirani, Chen Xu, Victoria Hatch, Roger W. Craig, Larry S. Tobacman, and William Lehman (Journal of molecular biology)

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Atomic model of a myosin filament in the relaxed state, John L. Woodhead, Fa-Qing Zhao, Roger W. Craig, Edward H. Egelman, Lorenzo Alamo, and Raul Padron (Nature)

Submissions from 2001

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Purification of native myosin filaments from muscle, Carlos Hidalgo, Raul Padron, Rachel Horowitz, Fa-Qing Zhao, and Roger W. Craig (Biophysical journal)

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The tip of the coiled-coil rod determines the filament formation of smooth muscle and nonmuscle myosin, Mitsuo Ikebe, Satoshi Komatsu, John L. Woodhead, Katsuhide Mabuchi, Reiko Ikebe, Junya Saito, Roger W. Craig, and Masaaki Higashihara (The Journal of biological chemistry)

Submissions from 1998

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Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export, Peter Lawrence Bangs, Brian Burke, Christine M. Powers, Roger W. Craig, Aruna Purohit, and Stephen J. Doxsey (The Journal of cell biology)

Submissions from 1996

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Myosin filament structure in vertebrate smooth muscle, Jun-Qing Xu, Beatrice A. Harder, Pedro Uman, and Roger W. Craig (The Journal of cell biology)

Submissions from 1994

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Unfixed cryosections of striated muscle to study dynamic molecular events, Jean-Francois Menetret and Roger W. Craig (Biophysical journal)

Submissions from 1989

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Structural changes induced in Ca2+-regulated myosin filaments by Ca2+ and ATP, Ling-Ling Young Frado and Roger W. Craig (The Journal of cell biology)

Submissions from 1987

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Structural changes accompanying phosphorylation of tarantula muscle myosin filaments, Roger W. Craig, Raul Padron, and John Kendrick-Jones (The Journal of cell biology)