Title

Non-ST-segment elevation acute coronary syndrome in patients with renal dysfunction: benefit of low-molecular-weight heparin alone or with glycoprotein IIb/IIIa inhibitors on outcomes. The Global Registry of Acute Coronary Events

UMMS Affiliation

Center for Outcomes Research

Date

11-4-2005

Document Type

Article

Medical Subject Headings

Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Coronary Disease; Drug Therapy, Combination; Female; Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Kidney Diseases; Male; Middle Aged; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Statistics as Topic; Syndrome; Treatment Outcome

Disciplines

Health Services Research

Abstract

AIMS:

To determine whether low-molecular-weight heparin (LMWH)+glycoprotein (GP) IIb/IIIa inhibitors provide greater benefit than unfractionated heparin (UFH)+GP IIb/IIIa inhibitors, irrespective of renal status.

METHODS AND RESULTS:

Patients in the Global Registry of Acute Coronary Events (GRACE) were divided into three groups according to creatinine clearance (CrCl): normal renal function (CrCl >60 mL/min), moderate renal dysfunction (30

CONCLUSION:

In patients with renal dysfunction and non-ST-segment elevation ACS, bleeding complications are more frequent and outcomes appear worse in individuals treated with UFH compared with LMWH. Combination therapy with LMWH and GP IIb/IIIa inhibitors appears to be better tolerated than with UFH and GP IIb/IIIa inhibitors.

Rights and Permissions

Citation: Eur Heart J. 2005 Nov;26(21):2285-93. Epub 2005 Jun 2. Link to article on publisher's site

Related Resources

Link to Article in PubMed