Combining warfarin and antiplatelet therapy after coronary stenting in the Global Registry of Acute Coronary Events: is it safe and effective to use just one antiplatelet agent
Center for Outcomes Research
Medical Subject Headings
Acute Coronary Syndrome; Aged; Anticoagulants; Aspirin; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Regression Analysis; Risk Assessment; Risk Factors; *Stents; Survival Analysis; Treatment Outcome; Warfarin
Health Services Research
AIMS: To identify factors associated with the use of single or dual antiplatelet therapy in patients prescribed warfarin following coronary stenting and to investigate whether single (aspirin or thienopyridine) vs. dual antiplatelet therapy plus warfarin leads to an excess of adverse outcomes.
METHODS AND RESULTS: We analysed data from 800 patients with an acute coronary syndrome who underwent coronary stenting (130 patients received a drug-eluting stent) and were discharged on warfarin and either dual (n = 580) or single (n = 220) antiplatelet therapy. The use of single antiplatelet therapy was more common in Europe than in the USA (34 vs. 17%, P < 0.001). There was no difference in major bleeding in hospital or in 6-month mortality or myocardial infarction. In the single antiplatelet group, the use of either aspirin or thienopyridine (clopidogrel or ticlopidine) in combination with warfarin resulted in similar outcomes.
CONCLUSION: Use of single vs. dual antiplatelet therapy and warfarin following stenting is common. In this observational study, there was no difference in mortality or myocardial infarction at 6 months; however, larger trials are needed to assert any firm recommendations.
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Citation: Eur Heart J. 2007 Jul;28(14):1717-22. Epub 2007 Jun 11. Link to article on publisher's site
Nguyen, Michael C.; Lim, Yean L.; Walton, Antony; Lefkovits, Jeffrey; Agnelli, Giancarlo; Goodman, Shaun G.; Budaj, Andrzej; Gulba, Dietrich C.; Allegrone, Jeanna; and Brieger, David, "Combining warfarin and antiplatelet therapy after coronary stenting in the Global Registry of Acute Coronary Events: is it safe and effective to use just one antiplatelet agent" (2007). GRACE Publications. Paper 48.