An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW)
Center for Outcomes Research
Medical Subject Headings
Osteoporosis; Osteoporosis, Postmenopausal; Osteoporotic Fractures; Fractures, Bone; Accidental Falls
Health Services Research | Musculoskeletal Diseases
OBJECTIVES: Patients with osteoarthritis have increased bone mass
METHODS: The Global Longitudinal Study of Osteoporosis in Women is a prospective multinational cohort of 60 393 non-institutionalised women aged ≥55 years who had visited primary care practices within the previous 2 years. Questionnaires were mailed at yearly intervals. Patients were classified as having osteoarthritis if they answered yes to the question, 'Has a doctor or other health provider ever said that you had osteoarthritis or degenerative joint disease?', and this was validated against primary care records in a subsample. Information on incident falls, fractures and covariates was self-reported. Cox and Poisson models were used for incident fractures and number of falls, respectively, to compute hazard ratios (HRs) and rate ratios (RRs) for baseline osteoarthritis status.
Of 51 386 women followed for a median of 2.9 years (interquartile range 2.1-3.0), 20 409 (40%) reported osteoarthritis. The adjusted HR for osteoarthritis predicting fracture was 1.21 (95% CI 1.13 to 1.30; p
Postmenopausal women with self-reported osteoarthritis have a 20% increased risk of fracture and experience 25% more falls than those without osteoarthritis. These data suggest that increased falls are the causal pathway of the association between osteoarthritis and fractures.
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Citation: Ann Rheum Dis. 2012 Jun 23. [Epub ahead of print] doi:10.1136/annrheumdis-2012-201451
Prieto-Alhambra, Daniel; Nogues, Xavier; Javaid, M. Kassim; Wyman, Allison; Arden, Nigel K.; Azagra, Rafael; Cooper, Cyrus; Adachi, Jonathan D.; Boonen, Steven; Chapurlat, Roland D.; Compston, Juliet E.; Gehlbach, Stephen H.; Greenspan, Susan L.; Hooven, Fred H.; Netelenbos, J. Coen; Pfeilschifter, Johannes; Rossini, Maurizio; Sambrook, Phillip N.; Silverman, Stuart; Siris, Ethel S.; Watts, Nelson B.; and Diez-Perez, Adolfo, "An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW)" (2012). GLOW Publications. 13.