Title

Panitumumab-Related Hypomagnesemia in Patients With Colorectal Cancer

UMMS Affiliation

Commonwealth Medicine, Clinical Pharmacy Services

Date

3-2009

Document Type

Article

Medical Subject Headings

Magnesium Deficiency; Receptor, Epidermal Growth Factor; Antibodies, Monoclonal; Colorectal Neoplasms

Disciplines

Pharmacy and Pharmaceutical Sciences

Abstract

Purpose: Hypomagnesemia is an adverse reaction associated with epidermal growth factor receptor (EGFR)–targeting monoclonal antibodies. Of the 2 EGFR antibodies approved by the US Food and Drug Administration—cetuximab and panitumumab—cetuximab-induced hypomagnesemia has been extensively characterized but panitumumab-induced hypomagnesemia has not.

Methods: In this retrospective study, the clinical course of hypomagnesemia is described in three 64- to 68-year-old men who received panitumumab monotherapy or panitumumab-plus-irinotecan therapy for colorectal cancer for 8 to 21 weeks.

Results: The onset of hypomagnesemia was variable, ranging from 1 week to 10 weeks following the initiation of panitumumab. Magnesium levels did not normalize until 4 to 8 weeks after discontinuation of the agent. Of the patients in the study, 2 had new onset of grade 3 hypomagnesemia 1 to 3 weeks after panitumumab was discontinued. Management was magnesium sulfate 2 g infusion weekly and magnesium oxide 1,200 mg oral repletion daily. With severe hypomagnesemia (grade 3 and higher) or significant diarrhea (grade 3 and higher), a daily infusion of magnesium sulfate 2 or 4 g was administered.

Conclusion: When administering panitumumab therapy, magnesium levels should be monitored from the initiation of the agent to at least 8 weeks following cessation. Hypomagnesemia usually can be managed with magnesium sulfate 2 to 4 g infusion weekly and magnesium oxide 1,200 mg oral repletion daily. Future research is warranted to identify simple and efficient strategies for monitoring and treating EGFR blockade with monoclonal antibody–associated hypomagnesemia.

Rights and Permissions

Hospital Pharmacy. 2009; 44 (3): 234-238