The Department of Cell and Developmental Biology at the University of Massachusetts Medical School is at the center of exciting new advances in understanding basic biological and biomedical processes to promote clinical and translational science. Research addresses the organization, assembly and activity of the regulatory machinery for cell growth and aging, differentiation and development, as well as genetic and epigenetic control of gene expression in human embryonic stem cells and lineage committed cells; with implications for treatment of cancers, bone diseases, reproductive disorders, genetic conditions and neurodegenerative and psychiatric disorders. This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Cell and Developmental Biology.


Submissions from 2016

Link

C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization, Ahmet Rasim Barutcu, Andrew J. Fritz, Sayyed K. Zaidi, Andre J. van Wijnen, Jane B. Lian, Janet L. Stein, Jeffrey A. Nickerson, Anthony N. Imbalzano, and Gary S. Stein (Journal of cellular physiology)

Link

CRISPR/dCas9-mediated transcriptional inhibition ameliorates the epigenetic dysregulation at D4Z4 and represses DUX4-fl in FSH muscular dystrophy, Charis L. Himeda, Takako I. Jones, and Peter L. Jones (Molecular therapy : the journal of the American Society of Gene Therapy)

Link

Scalpel or Straitjacket: CRISPR/Cas9 Approaches for Muscular Dystrophies, Charis L. Himeda, Takako I. Jones, and Peter L. Jones (Trends in pharmacological sciences)

PDF

Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes, Henry Huang, Eric S. Veien, Hong Zhang, David C. Ayers, and Jie Song (PLoS One)

PDF

Global gene expression profiling of JMJD6- and JMJD4-depleted mouse NIH3T3 fibroblasts, Yu-Jie Hu and Anthony N. Imbalzano (Scientific data)

PDF

Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD), Takako I. Jones, Megan Parilla, and Peter L. Jones (PloS one)

PDF

Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin, Tomohiro Kubo, Jason Brown, Karl D. Bellve, Branch Craige, Julie M. Craft, Kevin E. Fogarty, Karl-Ferdinand Lechtreck, and George B. Witman (Journal of cell science)

PDF

Promoter-enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase, Scott E. LeBlanc, Qiong Wu, Pallavi Lamba, Said Sif, and Anthony N. Imbalzano (Nucleic acids research)

PDF

Transcriptional Auto-Regulation of RUNX1 P1 Promoter, Milka Martinez, Marcela Hinojosa, Daniel J. Trombly, Violeta Morin, Janet L. Stein, Gary S. Stein, Amjad Javed, and Soraya E. Gutierrez (PloS one)

Link

The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position, Ji Young Mun, Robert W. Kensler, Samantha P. Harris, and Roger Craig (Journal of molecular and cellular cardiology)

Link

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit, Brian T. Nasipak, Teresita Padilla-Benavides, Qiong Wu, Anthony N. Imbalzano, Jeffrey A. Nickerson, and Dafydd R. Owen (Journal of medicinal chemistry)

Link

The cast of clasts: catabolism and vascular invasion during bone growth, repair, and disease by osteoclasts, chondroclasts, and septoclasts, Paul R. Odgren, Hanna Witwicka, and Pablo Reyes-Gutierrez (Connective tissue research)

PDF

Phosphorylation and calcium antagonistically tune myosin-binding protein C's structure and function, Michael J. Previs, Ji Young Mun, Arthur J. Michalek, Samantha Beck Previs, James Gulick, Jeffrey Robbins, David M. Warshaw, and Roger Craig (Proceedings of the National Academy of Sciences of the United States of America)

Link

Use of HCA in subproteome-immunization and screening of hybridoma supernatants to define distinct antibody binding patterns, Adam T. Szafran, Maureen G. Mancini, Jeffrey A. Nickerson, Dean P. Edwards, and Michael A. Mancini (Methods (San Diego, Calif.))

Link

Finding Shangri-La: Limiting the Impact of Senescence on Aging, Sally E. Trabucco and Hong Zhang (Cell stem cell)

Link

An approach to improve the resolution of helical filaments with a large axial rise and flexible subunits, Shixia Wang, John L. Woodhead, Fa-Qing Zhao, Guidenn Sulbaran, and Roger Craig (Journal of structural biology)

PDF

Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells, Qiong Wu, Soni Sharma, Hang Cui, Scott E. LeBlanc, Hong Zhang, Rohini Muthuswami, Jeffrey A. Nickerson, and Anthony N. Imbalzano (Oncotarget)

Link

Coordinated Dynamics of RNA Splicing Speckles in the Nucleus, Qiao Zhang, Krishna P. Kota, Samer G. Alam, Jeffrey A. Nickerson, Richard B. Dickinson, and Tanmay P. Lele (Journal of cellular physiology)

Submissions from 2015

PDF

DRC3 connects the N-DRC to dynein g to regulate flagellar waveform, Junya Awata, Kangkang Song, Jianfeng Lin, Stephen M. King, Michael J. Sanderson, Daniela Nicastro, and George B. Witman (Molecular biology of the cell)

PDF

Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells, Ahmet Rasim Barutcu, Bryan R. Lajoie, Rachel Patton McCord, Coralee E. Tye, Deli Hong, Terri L. Messier, Gillian Browne, Andre J. van Wijnen, Jane B. Lian, Janet L. Stein, Job Dekker, Anthony N. Imbalzano, and Gary S. Stein (Genome biology)

Link

Assembly of IFT trains at the ciliary base depends on IFT74, Jason M. Brown, Deborah A. Cochran, Branch Craige, Tomohiro Kubo, and George B. Witman (Current biology : CB)

Link

Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development, Ok Hyun Cho, Chandrashekara Mallappa, Jose Manuel Hernandez, Jaime A. Rivera-Perez, and Anthony N. Imbalzano (Developmental dynamics : an official publication of the American Association of Anatomists)

Link

Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies, Rama Rao Damerla, Cheng Cui, George C. Gabriel, Xiaoqin Liu, Branch Craige, Brian C. Gibbs, Richard Francis, You Li, Bishwanath Chatterjee, Jovenal T. San Agustin, Thibaut Eguether, Ramiah Subramanian, George B. Witman, Jacques L. Michaud, Gregory J. Pazour, and Cecilia W. Lo (Human molecular genetics)

PDF

Quantitative analysis of high-resolution, contrast-enhanced, cone-beam CT for the detection of intracranial in-stent hyperplasia, Thomas F. Flood, Imramsjah M. J. van der Bom, Lara Strittmatter, Ajit S. Puri, Gregory M. Hendricks, Ajay K. Wakhloo, and Matthew J. Gounis (Journal of neurointerventional surgery)

Link

Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus, Andrew Fritz, Rasim Barutcu, Lori Martin-Buley, Andre J. van Wijnen, Sayyed K. Zaidi, Anthony N. Imbalzano, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Journal of cellular biochemistry)

Link

p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency, Prachi N. Ghule, Ronglin Xie, Jennifer L. Colby, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Cell cycle (Georgetown, Tex.))

PDF

Spatial re-organization of myogenic regulatory sequences temporally controls gene expression, Akihito Harada, Chandrashekara Mallappa, Seiji Okada, John T. Butler, Stephen P. Baker, Jeanne B. Lawrence, Yasuyuki Ohkawa, and Anthony N. Imbalzano (Nucleic acids research)

Link

Facioscapulohumeral muscular dystrophy as a model for epigenetic regulation and disease, Charis L. Himeda, Takako I. Jones, and Peter L. Jones (Antioxidants and redox signaling)

Link

Dynein and intraflagellar transport, Yuqing Hou and George B. Witman (Experimental cell research)

PDF

Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6, Yu-Jie Hu, Houda Belaghzal, Wen-Yu Hsiao, Jun Qi, James E. Bradner, David A. Guertin, Said Sif, and Anthony N. Imbalzano (Nucleic acids research)

PDF

Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy, Takako I. Jones, Oliver D. King, Charis L. Himeda, Sachiko Homma, Jennifer C. J. Chen, Mary Lou. Beermann, Chi Yan, Charles P. Emerson Jr., Jeffrey B. Miller, Kathryn R. Wagner, and Peter L. Jones (Clinical epigenetics)

PDF

Exploring the Role of FUS Mutants from Stress Granule Incorporation to Nucleopathy in Amyotrophic Lateral Sclerosis: A Dissertation, Hae Kyung Ko (GSBS Dissertations and Theses)

PDF

Reduced tubulin polyglutamylation suppresses flagellar shortness in Chlamydomonas, Tomohiro Kubo, Masafumi Hirono, Takumi Aikawa, Ritsu Kamiya, and George B. Witman (Molecular biology of the cell)

Link

Templated repair of long bone defects in rats with bioactive spiral-wrapped electrospun amphiphilic polymer/hydroxyapatite scaffolds, Artem B. Kutikov, Jordan D. Skelly, David C. Ayers, and Jie Song (ACS applied materials and interfaces)

PDF

p53 protects against genome instability following centriole duplication failure, Bramwell G. Lambrus, Yumi Uetake, Kevin M. Clutario, Vikas Daggubati, Michael Snyder, Greenfield Sluder, and Andrew J. Holland (The Journal of cell biology)

PDF

Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys, Thuy Lam, Paige L. Williams, Mary M. Lee, Susan A. Korrick, Linda S. Birnbaum, Jane S. Burns, Oleg Sergeyev, Boris Revich, Larisa M. Altshul, Donald G. Patterson Jr, and Russ Hauser (Environmental health perspectives)

Link

Pacemaker-induced transient asynchrony suppresses heart failure progression, Kyounghwan Lee, Roger Craig, and David A. Kass (Science translational medicine)

Link

Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM, Kyounghwan Lee, Samantha P. Harris, Sakthivel Sadayappan, and Roger Craig (Journal of molecular biology)

Link

Emerging preclinical animal models for FSHD, Angela Lek, Fedik Rahimov, Peter L. Jones, and Louis M. Kunkel (Trends in molecular medicine)

Link

PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection, David G. McEwan, Paul R. Odgren, Dirk Bumann, and Ivan Dikic (Cell host and microbe)

PDF

CFAP54 is required for proper ciliary motility and assembly of the central pair apparatus in mice, Casey W. McKenzie, Branch Craige, Tiffany V. Kroeger, Rozzy Finn, Todd A. Wyatt, Joseph H. Sisson, Jacqueline A. Pavlik, Lara Strittmatter, Gregory M. Hendricks, George B. Witman, and Lance Lee (Molecular biology of the cell)

Link

Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors, Munemasa Mori, John E. Mahoney, Maria R. Stupnikov, Jesus R. Paez-Cortez, Aleksander D. Szymaniak, Xaralabos Varelas, Dan B. Herrick, James Schwob, Hong Zhang, and Wellington V. Cardoso (Development (Cambridge, England))

Link

Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme, Brian T. Nasipak, Teresita Padilla-Benavides, Karin M. Green, John D. Leszyk, Wenjie Mao, Silvana Konda, Said Sif, Scott A. Shaffer, Yasuyuki Ohkawa, and Anthony N. Imbalzano (Nature communications)

PDF

Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell, Srujana Neelam, T J. Chancellor, Yuan Li, Jeffrey A. Nickerson, Kyle J. Roux, Richard B. Dickinson, and Tanmay P. Lele (Proceedings of the National Academy of Sciences of the United States of America)

Link

Brg1 Controls the Expression of Pax7 to Promote Viability and Proliferation of Mouse Primary Myoblasts, Teresita Padilla-Benavides, Brian T. Nasipak, and Anthony N. Imbalzano (Journal of cellular physiology)

PDF

Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling, Michael J. Previs, Benjamin L. Prosser, Ji Young Mun, Samantha Beck Previs, James Gulick, Kyounghwan Lee, Jeffrey Robbins, Roger Craig, W J. Lederer, and David M. Warshaw (Science advances)

PDF

Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm, Jovenal T. San Agustin, Gregory J. Pazour, and George B. Witman (Molecular biology of the cell)

PDF

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport, Miriam Schmidts, Yuqing Hou, Hannah M. Mitchison, and George B. Witman (Nature communications)

Link

In Situ Localization of N and C Termini of Subunits of the Flagellar Nexin-Dynein Regulatory Complex (N-DRC) Using SNAP Tag and Cryo-electron Tomography, Kangkang Song, Junya Awata, Douglas Tritschler, Raqual Bower, George B. Witman, Mary E. Porter, and Daniela Nicastro (The Journal of biological chemistry)

Link

Supervillin binds the Rac/Rho-GEF trio and increases trio-mediated rac1 activation, Kyonghee Son, Tara C. Smith, and Elizabeth J. Luna (Cytoskeleton (Hoboken, N.J.))

Link

Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle, Janelle M. Spinazzola, Tara C. Smith, Min Liu, Elizabeth J. Luna, and Elisabeth R. Barton (Human molecular genetics)

Link

Howard Holtzer -- developmental and cell biologist 1922-2014, Frank E. Stockdale, Joseph W. Sanger, and Charles P. Emerson Jr. (Developmental biology)

PDF

An invertebrate smooth muscle with striated muscle myosin filaments, Guidenn Sulbaran, Lorenzo Alamo, Antonio Pinto, Gustavo Marquez, Franklin Mendez, Raul Padron, and Roger Craig (Proceedings of the National Academy of Sciences of the United States of America)

Link

Unfolding the story of chromatin organization in senescent cells, Eric C. Swanson, Lindsy M. Rapkin, David P. Bazett-Jones, and Jeanne B. Lawrence (Nucleus (Austin, Tex.))

Link

Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS, Helene Tran, Sandra Almeida, Jill Moore, Tania F. Gendron, UmaDevi Chalasani, Yubing Lu, Xing Du, Jeffrey A. Nickerson, Leonard Petrucelli, Zhiping Weng, and Fen-Biao Gao (Neuron)

PDF

Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells, Daniel J. Trombly, Troy W. Whitfield, Srivatsan Padmanabhan, Jonathan A. R. Gordon, Jane B. Lian, Andre J. Van Wijnen, Kaleem Zaidi, Janet L. Stein, and Gary S. Stein (BMC genomics)

PDF

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology, Hanna Witwicka, Sung-Yong Hwang, Pablo Reyes-Gutierrez, Hong Jia, Paul E. Odgren, Leah Rae Donahue, Mark J. Birnbaum, and Paul R. Odgren (PloS one)

PDF

TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption, Hanna Witwicka, Hong Jia, Artem B. Kutikov, Pablo Reyes-Gutierrez, Xiang-Dong Li, and Paul R. Odgren (PloS one)

Link

Through Thick and Thin-Interfilament Communication in Muscle, John L. Woodhead and Roger Craig (Biophysical journal)

Link

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation, Qiong Wu, Pasil A. Madany, Jacqueline Akech, Jason Dobson, Stephen Douthwright, Gillian Browne, Jennifer L. Colby, Georg E. Winter, James E. Bradner, Jitesh Pratap, Greenfield Sluder, Rohit Bhargava, Simion I. Chiosea, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Jane B. Lian, Jeffrey A. Nickerson, and Anthony N. Imbalzano (Journal of cellular physiology)

Link

Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response, Seungchan Yang, Alexandre Jose Christino Quaresma, Jeffrey A. Nickerson, Karin M. Green, Scott A. Shaffer, Anthony N. Imbalzano, Lori A. Martin-Buley, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Journal of cell science)

PDF

Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone, T. Tony Yang, Jimmy Su, Won-Jing Wang, Branch Craige, George B. Witman, Meng-Fu Bryan. Tsou, and Jung-Chi Liao (Scientific reports)

PDF

Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption, Liang Ye, Leslie R. Morse, Li Zhang, Hajime Sasaki, Jason C. Mills, Paul R. Odgren, Greg Sibbel, James R.L. Stanley, Gee Wong, Ariane Zamarioli, and Ricardo A. Battaglino (PLoS genetics)

Link

Extra-embryonic Wnt3 regulates the establishment of the primitive streak in mice, Yeonsoo Yoon, Tingting Huang, Giovane G. Tortelote, Maki Wakamiya, Anna-Katerina Hadjantonakis, Richard R. Behringer, and Jaime A. Rivera-Perez (Developmental biology)

Submissions from 2014

Link

NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone, Junya Awata, Saeko Takada, Clive Standley, Karl-Ferdinand Lechtreck, Karl D. Bellve, Gregory J. Pazour, Kevin E. Fogarty, and George B. Witman (Journal of cell science)

PDF

The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter, Rasim Barutcu, Phillip W. Tai, Hai Wu, Jonathan A. R. Gordon, Troy W. Whitfield, Jason Dobson, Anthony N. Imbalzano, Jane B. Lian, Andre J. van Wijnen, Janet L. Stein, and Gary S. Stein (Nucleic acids research)

Link

The Chlamydomonas genome project: a decade on, Ian K. Blaby, George B. Witman, and Simon Prochnik (Trends in plant science)

Link

Tom D. Humphreys II: a pioneer of molecular embryology, Bruce P. Brandhorst and Charles P. Emerson Jr. (Molecular reproduction and development)

Link

Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function, Jane S. Burns, Paige L. Williams, Susan A. Korrick, Russ Hauser, Oleg Sergeyev, Boris Revich, Thuy Lam, and Mary M. Lee (American journal of epidemiology)

Link

High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm, Benjamin R. Carone, Jui-Hung Hung, Sarah J. Hainer, Min-Te Chou, Dawn M. Carone, Zhiping Weng, Thomas G. Fazzio, and Oliver J. Rando (Developmental cell)

Link

Flipping a phosphate switch on kinesin-II to turn IFT around, Branch Craige and George B. Witman (Developmental cell)

Link

Structure, sarcomeric organization, and thin filament binding of cardiac myosin-binding protein-C, Roger Craig, Kyounghwan Lee, Ji Young Mun, Iratxe Torre, and Pradeep K. Luther (Pflugers Archiv : European journal of physiology)

Link

Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin, L. Damiano, K. M. Stewart, Nathalie Cohet, J. K. Mouw, J. N. Lakins, J. Debnath, D. Reisman, Jeffrey A. Nickerson, Anthony N. Imbalzano, and V. M. Weaver (Oncogene)

PDF

hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3, Jason R. Dobson, Hanna Taipaleenmaki, Yu-Jie Hu, Deli Hong, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Jane B. Lian, and Jitesh Pratap (Cancer cell international)

Link

Link Between DNA Damage and Centriole Disengagement/Reduplication in Untransformed Human Cells, Stephen Douthwright and Greenfield Sluder (Journal of cellular physiology)

PDF

Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour (PLoS genetics)

Link

Fidelity of Histone Gene Regulation is Obligatory for Genome Replication and Stability, Prachi N. Ghule, Ronglin Xie, Ricardo F. Medina, Jennifer L. Colby, Stephen N. Jones, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen, and Gary S. Stein (Molecular and cellular biology)

Link

Stable C0T-1 repeat RNA is abundant and is associated with euchromatic interphase chromosomes, Lisa L. Hall, Dawn M. Carone, Alvin V. Gomez, Heather J. Kolpa, Meg Byron, Nitish Mehta, Frank O. Fackelmayer, and Jeanne B. Lawrence (Cell)

Link

N-linked polylactosamine glycan synthesis is regulated by co-expression of beta3GnT2 and GCNT2, Timothy R. Henion and Gerald A. Schwarting (Journal of cellular physiology)

Link

Myogenic Enhancers Regulate Expression of the Facioscapulohumeral Muscular Dystrophy-Associated DUX4 Gene, Charis L. Himeda, Celine Debarnot, Sachiko Homma, Mary Lou Beermann, Jeffrey B. Miller, Peter L. Jones, and Takako I. Jones (Molecular and cellular biology)

PDF

Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation, Tingting Huang (GSBS Dissertations and Theses)

Link

Senescence-associated β-galactosidase activity marks the visceral endoderm of mouse embryos but is not indicative of senescence, Tingting Huang and Jaime A. Rivera-Perez (Genesis)

PDF

Characterization of THB1, a Chlamydomonas reinhardtii truncated hemoglobin: linkage to nitrogen metabolism and identification of lysine as the distal heme ligand, Eric A. Johnson, Selena L. Rice, Matthew R. Preimesberger, Dillon B. Nye, Lukas Gilevicius, Belinda B. Wenke, Jason Brown, George B. Witman, and Juliette T. J. Lecomte (Biochemistry)

PDF

Identifying diagnostic DNA methylation profiles for facioscapulohumeral muscular dystrophy in blood and saliva using bisulfite sequencing, Takako I. Jones, Chi Yan, Peter Sapp, Diane McKenna-Yasek, Peter B. Kang, Colin Quinn, Johnny S. Salameh, Oliver D. King, and Peter L. Jones (Clinical epigenetics)

PDF

A conserved flagella-associated protein in Chlamydomonas, FAP234, is essential for axonemal localization of tubulin polyglutamylase TTLL9, Tomohiro Kubo, Haru-aki Yanagisawa, Zhongmei Liu, Rie Shibuya, Masafumi Hirono, and Ritsu Kamiya (Molecular biology of the cell)

PDF

Rapid prototyping amphiphilic polymer/hydroxyapatite composite scaffolds with hydration-induced self-fixation behavior, Artem B. Kutikov, Anvesh Gurijala, and Jie Song (Tissue Engineering Part C: Methods)

Link

Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys, Thuy Lam, Paige L. Williams, Mary M. Lee, Susan A. Korrick, Linda S. Birnbaum, Jane S. Burns, Oleg Sergeyev, Boris Revich, Larisa M. Altshul, Donald G. Patterson Jr, Wayman E. Turner, and Russ Hauser (Environment international)

Link

PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition, Alex K. Lancaster, Andrew Nutter-Upham, Susan Lindquist, and Oliver D. King (Bioinformatics (Oxford, England))

Link

Differential Muscle Hypertrophy Is Associated with Satellite Cell Numbers and Akt Pathway Activation Following Activin Type IIB Receptor Inhibition in Mtm1 p.R69C Mice, Michael W. Lawlor, Marissa G. Viola, Hui Meng, Rachel V. Edelstein, Fujun Liu, Ke Yan, Elizabeth J. Luna, Alexandra Lerch-Gaggl, Raymond G. Hoffmann, Christopher R. Pierson, Anna Buj-Bello, Jennifer L. Lachey, Scott Pearsall, Lin Yang, Cecilia J. Hillard, and Alan H. Beggs (The American journal of pathology)

PDF

The PPARgamma locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner, Scott E. LeBlanc, Qiong Wu, A. Rasim Barutcu, Hengyi Xiao, Yasuyuki Ohkawa, and Anthony N. Imbalzano (PloS one)

Link

A comparative study of zwitterionic ligands-mediated mineralization and the potential of mineralized zwitterionic matrices for bone tissue engineering., Pingsheng Liu, Erin Emmons, and Jie Song (Journal of materials chemistry. B, Materials for biology and medicine)

PDF

Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice, Stephen Lyle, Kathleen Hoover, Cansu Colpan, Zhiqing Zhu, Zdenka Matijasevic, and Stephen N. Jones (PloS one)

Link

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner, Rachel Miloslavski, Elad Cohen, Adam Avraham, Yifat Iluz, Zvi Hayouka, Judith Kasir, Rajini R. Mudhasani, Stephen N. Jones, Nadine Cybulski, Markus A. Ruegg, Ola Larsson, Valentina Gandin, Arjuna Rajakumar, Ivan Topisirovic, and Oded Meyuhas (Journal of molecular cell biology)

PDF

Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism, Ji Young Mun, Michael J. Previs, Hope Y. Yu, James Gulick, Larry S. Tobacman, Samantha Beck Previs, Jeffrey Robbins, David M. Warshaw, and Roger Craig (Proceedings of the National Academy of Sciences of the United States of America)

PDF

HDAC4 integrates PTH and sympathetic signaling in osteoblasts, Arnaud Obri, Munevver Parla. Makinistoglu, Hong Zhang, and Gerard Karsenty (The Journal of cell biology)

Link

Osteoclast inhibition impairs chondrosarcoma growth and bone destruction, Jesse E. Otero, Jeff W. Stevens, Allison E. Malandra, Douglas C. Fredericks, Paul R. Odgren, Joseph A. Buckwalter, and Jose Morcuende (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)

PDF

Cooperative binding of the outer arm-docking complex underlies the regular arrangement of outer arm dynein in the axoneme, Mikito Owa, Akane Furuta, Jiro Usukura, Fumio Arisaka, Stephen M. King, George B. Witman, Ritsu Kamiya, and Ken-ichi Wakabayashi (Proceedings of the National Academy of Sciences of the United States of America)

PDF

Reassessment of the role of TSC, mTORC1 and microRNAs in amino acids-meditated translational control of TOP mRNAs, Ilona Patursky-Polischuk, Judith Kasir, Rachel Miloslavski, Zvi Hayouka, Mirit Hausner-Hanochi, Miri Stolovich-Rain, Pinchas Tsukerman, Moshe Biton, Rajini R. Mudhasani, Stephen N. Jones, and Oded Meyuhas (PloS one)

Link

A new role for Hedgehogs in juxtacrine signaling, Christopher A. Pettigrew, Eva Asp, and Charles P. Emerson Jr. (Mechanisms of development)

PDF

Uniform nomenclature for the mitochondrial contact site and cristae organizing system, Nikolaus Pfanner, Paul R. Odgren PhD, Walter Neupert, and Jodi Nunnari (The Journal of cell biology)