The Department of Cell and Developmental Biology at the University of Massachusetts Medical School is at the center of exciting new advances in understanding basic biological and biomedical processes to promote clinical and translational science. Research addresses the organization, assembly and activity of the regulatory machinery for cell growth and aging, differentiation and development, as well as genetic and epigenetic control of gene expression in human embryonic stem cells and lineage committed cells; with implications for treatment of cancers, bone diseases, reproductive disorders, genetic conditions and neurodegenerative and psychiatric disorders. This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Cell and Developmental Biology.

Submissions from 2010

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Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression, Kyle C. Kurek, Sara Del Mare, Zaidoun Salah, Suhaib Abdeen, Hussain Sadiq, Suk Hee Lee, Eugenio Gaudio, Nicola Zanesi, Kevin B. Jones, Barry DeYoung, Gail Amir, Mark Gebhardt, Matthew Warman, Gary S. Stein, Janet L. Stein, Jane B. Lian, and Rami I. Aqeilan (Cancer research)

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Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility, David T. Leong, Jitesh Pratap, Barry P. Pereira, Saminathan S. Nathan, Jason R. Dobson, Jane B. Lian, Yoshiaki Ito, Gary S. Stein, Manuel Salto-Tellez, Simon M. Cool, Andre J. Van Wijnen, Joleen Lim, Xuewei Goh, Hui S. Kwok, and P. Mathijs Voorhoeve (Breast cancer research : BCR)

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Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathway, Ling Ling, Christian Dombrowski, Kin Mun Foong, Larisa M. Haupt, Gary S. Stein, Victor Nurcombe, Andre J. Van Wijnen, and Simon M. Cool (The Journal of biological chemistry)

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Glycosaminoglycans modulate RANKL-induced osteoclastogenesis, Ling Ling, Sadasivam Murali, Gary S. Stein, Andre J. Van Wijnen, and Simon M. Cool (Journal of cellular biochemistry)

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Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function, Chandrashekara Mallappa, Brian T. Nasipak, Letitiah Etheridge, Elliot J. Androphy, Stephen N. Jones, Charles G. Sagerstrom, Yasuyuki Ohkawa, and Anthony N. Imbalzano (Molecular and cellular biology)

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Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl, Emily F. Mason, Yuxing Zhao, Pankuri Goraksha-Hicks, Jonathan L. Coloff, Hugh S. Gannon, Stephen N. Jones, and Jeffrey C. Rathmell (Cancer research)

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Cdk5 Regulates the Ubiquitination of PSD-95 in Neurons, Maria A. Morabito and Michael Bianchetta (Society for Neuroscience's 2010 Annual Meeting)

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An essential role for Dicer in adipocyte differentiation, Rajini R. Mudhasani, Anthony N. Imbalzano, and Stephen N. Jones (Journal of cellular biochemistry)

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Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies, Paul R. Odgren, Craig H. Pratt, Carole A. MacKay, April Mason-Savas, Michelle Curtain, Lindsay S. Shopland, Tsutomu Ichicki, John P. Sundberg, and Leah Rae Donahue (PloS one)

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The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss, Jitesh Pratap, Jacqueline Akech, John J. Wixted, Gabriela Szabo, Sadiq Hussain, Meghan E. McGee-Lawrence, Xiaodong Li, Krystin Bedard, Robinder J. Dhillon, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Jennifer J. Westendorf, and Jane B. Lian (Molecular cancer therapeutics)

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Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis, Meng Qiao, Yaqi Wang, Xiaoen Xu, Jing Lu, Yougli Dong, Wufan Tao, Janet L. Stein, Gary S. Stein, James D. Iglehart, Qian Shi, and Arthur B. Pardee (Molecular cell)

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Culture of whole mouse embryos at early postimplantation to organogenesis stages: developmental staging and methods, Jaime A. Rivera-Pérez, Vanessa Jones, and Patrick P. L. Tam (Methods in enzymology)

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Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice, JongDae Shin, Michael Bossenz, Young Chung, Hong Ma, Meg Byron, Naoko Taniguchi-Ishigaki, Xiaochun Zhu, Jiao Baowei, Lisa L. Hall, Michael R. Green, Stephen N. Jones, Irm Hermans-Borgmeyer, Jeanne B. Lawrence, and Ingolf Bach (Nature)

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Centriole duplication: analogue control in a digital age, Greenfield Sluder and Alexey Khodjakov (Cell biology international)

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Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis, Hayla Karen Sluss, Hugh S. Gannon, Andrew H. Coles, Qichang Shen, Christine M. Eischen, and Stephen N. Jones (Molecular cancer research : MCR)

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Novel interactors and a role for supervillin in early cytokinesis, Tara C. Smith, Zhiyou Fang, and Elizabeth J. Luna (Cytoskeleton (Hoboken, N.J.))

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Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer, Gary S. Stein, Janet L. Stein, Andre J. Van Wijnen, Jane B. Lian, Martin A. Montecino, Carlo M. Croce, Je-Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan, Sayyed K. Zaidi, and Daniel W. Young (Advances in enzyme regulation)

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Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments, Gary S. Stein, Andre J. Van Wijnen, Jane B. Lian, Anthony N. Imbalzano, Martin A. Montecino, Sayyed K. Zaidi, Jane B. Lian, Jeffrey A. Nickerson, and Janet L. Stein (Critical reviews in eukaryotic gene expression)

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Social Support to Empower Parents (STEP): an intervention for parents of young children newly diagnosed with type 1 diabetes, Susan Sullivan-Bolyai, Carol A. Bova, Katherine Leung, Allison Trudeau, Mary M. Lee, and Philip Gruppuso (The Diabetes educator)

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Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis, Yumi Uetake and Greenfield Sluder (Current biology : CB)

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The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells, Margaretha Van der Deen, Jacqueline Akech, Tao Wang, Thomas J. Fitzgerald, Dario C. Altieri, Lucia R. Languino, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Journal of cellular biochemistry)

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Mechanisms of sperm-egg interactions: between sugars and broken bonds, Pablo E. Visconti and Harvey M. Florman (Science signaling)

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Blood lead levels and delayed onset of puberty in a longitudinal study of Russian boys, Paige L. Williams, Oleg Sergeyev, Mary M. Lee, Susan A. Korrick, Jane S. Burns, Olivier Humblet, Julie T. Del Prato, Boris Revich, and Russ Hauser (Pediatrics)

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Androgen profiles during pubertal Leydig cell development in mice, Xiufeng Wu, Ramamani Arumugam, Ningning Zhang, and Mary M. Lee (Reproduction (Cambridge, England))

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PAMM: a redox regulatory protein that modulates osteoclast differentiation, Yan Xu, Leslie R. Morse, Raquel Assed Bezerra da Silva, Paul R. Odgren, Hajime Sasaki, Philip Stashenko, and Ricardo A. Battaglino (Antioxidants and redox signaling)

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Subnuclear localization and intranuclear trafficking of transcription factors, Sayyed K. Zaidi, Ricardo F. Medina, Shirwin M. Pockwinse, Rachit Bakshi, Krishna P. Kota, Syed A. Ali, Daniel W. Young, Jeffrey A. Nickerson, Amjad Javed, Martin A. Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information, Sayyed K. Zaidi, Daniel W. Young, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Molecular and cellular biology)

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Mitotic bookmarking of genes: a novel dimension to epigenetic control, Sayyed K. Zaidi, Daniel W. Young, Martin A. Montecino, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Nature reviews. Genetics)

Submissions from 2009

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Prostate cancer regulatory networks, Dario C. Altieri, Lucia R. Languino, Jane B. Lian, Janet L. Stein, Irwin Leav, Andre J. Van Wijnen, Zhong Jiang, and Gary S. Stein (Journal of cellular biochemistry)

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Book Review: Current Hypotheses and Research Milestones in Alzheimer's Disease, Athena Andreadis (Journal of Alzheimer's Disease)

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Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis, Rami I. Aqeilan, John P. Hagan, Alain de Bruin, Maysoon Rawahneh, Zaidoun Salah, Eugenio Gaudio, Hasan Siddiqui, Stefano Volinia, Hansjuerg Alder, Jane B. Lian, Gary S. Stein, and Carlo M. Croce (Endocrinology)

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PSD-95 Tyrosine Phosphorylation and Pyk2 Binding Are Regulated by Cdk5, Michael Bianchetta and Maria A. Morabito (Society for Neuroscience's 2009 Annual Meeting)

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Effects of review on medical students' recall of different types of neuroanatomical content, Susan Billings-Gagliardi and Kathleen M. Mazor (Academic medicine : journal of the Association of American Medical Colleges)

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Predictors of serum dioxins and PCBs among peripubertal Russian boys, Jane S. Burns, Paige L. Williams, Oleg Sergeyev, Susan Korrick, Mary M. Lee, Boris Revich, Larisa Altshul, Donald G. Patterson, Wayman E. Turner, Larry L. Needham, Igor Saharov, and Russ Hauser (Environmental health perspectives)

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Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells, John T. Butler, Lisa L. Hall, Kelly P. Smith, and Jeanne B. Lawrence (Journal of cellular biochemistry)

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Consensus statement on the use of gonadotropin-releasing hormone analogs in children, Jean-Claude Carel, Erica A. Eugster, Alan Rogol, Lucia Ghizzoni, Mark R. Palmert, Mary M. Lee, and ESPE-LWPES GnRH Analogs Consensus Conference Group (Pediatrics)

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Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination, Xin-Zi Chi, Jiyeon Kim, Yong-Hee Lee, Jung-Won Lee, Kyeong-Sook Lee, Hee-Jun Wee, Wun-Jae Kim, Woo-Yoon Park, Byung-Chul Oh, Gary S. Stein, Yoshiaki Ito, Andre J. Van Wijnen, and Suk-Chul Bae (Cancer research)

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The ING gene family in the regulation of cell growth and tumorigenesis, Andrew H. Coles and Stephen N. Jones (Journal of cellular physiology)

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Aurora-A kinase is essential for bipolar spindle formation and early development, Dale O. Cowley, Jaime A. Rivera-Pérez, Mark Schliekelman, Yizhou Joseph He, Trudy G. Oliver, Lucy Lu, Ryan O'Quinn, E. D. Salmon, Terry Magnuson, and Terry Van Dyke (Molecular and cellular biology)

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Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency, Jessica Lynn Crowley, Tara C. Smith, Zhiyou Fang, Norio Takizawa, and Elizabeth J. Luna (Molecular biology of the cell)

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SWI/SNF-independent nuclease hypersensitivity and an increased level of histone acetylation at the P1 promoter accompany active transcription of the bone master gene Runx2, Fernando Cruzat, Berta Henriquez, Alejandro Villagra, Matias Hepp, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Anthony N. Imbalzano, Gary S. Stein, and Martin A. Montecino (Biochemistry)

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Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer, Kakoli Das, David Tai Leong, Anurag Gupta, Liang Shen, Thomas Putti, Gary S. Stein, Andre J. Van Wijnen, and Manuel Salto-Tellez (European journal of cancer (Oxford, England : 1990))

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Total internal reflection fluorescence (TIRF) microscopy of Chlamydomonas flagella, Benjamin D. Engel, Karl-Ferdinand Lechtreck, Tsuyoshi Sakai, Mitsuo Ikebe, George B. Witman, and Wallace F. Marshall (Methods in cell biology)

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Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections, Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, Mark J. Birnbaum, and Paul R. Odgren (The American journal of pathology)

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Secreted frizzled related protein 1 is a target to improve fracture healing, Tripti Gaur, John J. Wixted, Sadiq Hussain, Shannon L. O'Connell, Elise F. Morgan, David C. Ayers, Barry S. Komm, Peter V. N. Bodine, Gary S. Stein, and Jane B. Lian (Journal of cellular physiology)

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The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types, Prachi N. Ghule, Zbigniew Dominski, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular physiology)

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The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis, Larisa M. Haupt, Sadasivam Murali, Foong Kin Mun, Nadiya M. Teplyuk, Leong Fong Mei, Gary S. Stein, Andre J. Van Wijnen, Victor Nurcombe, and Simon M. Cool (Journal of cellular physiology)

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The influence of endocrine disruptors on pubertal timing, Elka Jacobson-Dickman and Mary M. Lee (Current opinion in endocrinology, diabetes, and obesity)

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Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice, Ya-Huei Kuo, Sayyed K. Zaidi, Svetlana Gornostaeva, Toshihisa Komori, Gary S. Stein, and Lucio H. Castilla (Blood)

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Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro, Nichole E. Lapointe, Peleg M. Horowitz, Angela L. Guillozet-Bongaarts, Andres Silva, Athena Andreadis, and Lester I. Binder (Biochemistry)

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The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella, Karl-Ferdinand Lechtreck, Eric C. Johnson, Tsuyoshi Sakai, Deborah A. Cochran, Bryan A. Ballif, John Rush, Gregory J. Pazour, Mitsuo Ikebe, and George B. Witman (The Journal of cell biology)

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HA-tagging of putative flagellar proteins in Chlamydomonas reinhardtii identifies a novel protein of intraflagellar transport complex B, Karl-Ferdinand Lechtreck, Scott Luro, Junya Awata, and George B. Witman (Cell motility and the cytoskeleton)

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High-speed digital imaging of ependymal cilia in the murine brain, Karl-Ferdinand Lechtreck, Michael J. Sanderson, and George B. Witman (Methods in cell biology)

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Tropomyosin and the steric mechanism of muscle regulation, William Lehman and Roger W. Craig (Advances in experimental medicine and biology)

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Structural basis for the activation of muscle contraction by troponin and tropomyosin, William Lehman, Agnieszka Galinska-Rakoczy, Victoria Hatch, Larry S. Tobacman, and Roger W. Craig (Journal of molecular biology)

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Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation, Zhaoyong Li, Mohammad Q. Hassan, Mohammed Jafferji, Rami I. Aqeilan, Ramiro Garzon, Carlo M. Croce, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (The Journal of biological chemistry)

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CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P, Partha Mitra, Prachi N. Ghule, Margaretha Van der Deen, Ricardo F. Medina, Ronglin Xie, William F. Holmes, Xin Ye, Keiichi I. Nakayama, J. Wade Harper, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen (Journal of cellular physiology)

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The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells, Samisubbu R. Naidu, Ian M. Love, Anthony N. Imbalzano, Steven R. Grossman, and Elliot J. Androphy (Oncogene)

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The biochemistry of RNA metabolism studied in situ, Jeffrey A. Nickerson (RNA biology)

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Do Atypical Antipsychotic Agents Trigger Autoimmune Diabetes?, Benjamin U. Nwosu, Olga T. Hardy, Amanda Angelescu, Leslie A. Soyka, and Mary M. Lee (Endocrinologist)

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Pseudohypoparathyroidism type 1a and insulin resistance in a child, Benjamin U. Nwosu and Mary M. Lee (Nature reviews. Endocrinology)

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The Chlamydomonas Flagellum as a Model for Human Ciliary Disease, Gregory J. Pazour and George B. Witman (The Chlamydomonas Sourcebook)

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Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2, B. Perdu, Paul R. Odgren, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul (Calcified tissue international)

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Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1), Barry P. Pereira, Ye-fang Zhou, Anurag Gupta, David T. Leong, Khin Zarchi Zarchi Aung, Ling Ling, Robert W. H. Pho, Mario Galindo, Manuel Salto-Tellez, Gary S. Stein, Simon M. Cool, Andre J. Van Wijnen, and Saminathan S. Nathan (Journal of cellular physiology)

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Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression, Jitesh Pratap, Karen M. Imbalzano, Jean. M. Underwood, Nathalie Cohet, Karthiga Devi Gokul, Jacqueline Akech, Andre J. Van Wijnen, Janet L. Stein, Anthony N. Imbalzano, Jeffrey A. Nickerson, Jane B. Lian, and Gary S. Stein (Cancer research)

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Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells, Inga A. San Martin, Nelson Varela, Marcia Gaete, Karina Villegas, Mariana Osorio, Julio Tapia, Marcelo Antonelli, Edna E. Mancilla, Barry P. Pereira, Saminathan S. Nathan, Jane B. Lian, Janet L. Stein, Gary S. Stein, Andre J. Van Wijnen, and Mario Galindo (Journal of cellular physiology)

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Pluripotency: toward a gold standard for human ES and iPS cells, Kelly P. Smith, Mai X. Luong, and Gary S. Stein (Journal of cellular physiology)

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Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer, Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande, and Mohammad Q. Hassan (Annals of the New York Academy of Sciences)

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Transcription-factor-mediated epigenetic control of cell fate and lineage commitment, Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande, and Mohammad Q. Hassan (Biochemistry and cell biology = Biochimie et biologie cellulaire)

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Altered chromatin modifications in AML1/RUNX1 breakpoint regions involved in (8;21) translocation, Marcela Stuardo, Milka Martinez, Karla Hildago, Martin A. Montecino, Amjad Javed, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Soraya E. Gutierrez (Journal of cellular physiology)

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The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts, Nadiya M. Teplyuk, Larisa M. Haupt, Ling Ling, Christian Dombrowski, Foong Kin Mun, Saminathan S. Nathan, Jane B. Lian, Janet L. Stein, Gary S. Stein, Simon M. Cool, and Andre J. Van Wijnen (Journal of cellular biochemistry)

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The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts, Nadiya M. Teplyuk, Ying Zhang, Yang Lou, John R. Hawse, Mohammad Q. Hassan, Viktor Teplyuk, Jitesh Pratap, Mario Galindo, Janet L. Stein, Gary S. Stein, Jane B. Lian, and Andre J. Van Wijnen (Molecular endocrinology (Baltimore, Md.))

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The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA, Nobuhisa Umeki, HyunSuk Jung, Shinya Watanabe, Tsuyoshi Sakai, Xiang-Dong Li, Reiko Ikebe, Roger W. Craig, and Mitsuo Ikebe (Proceedings of the National Academy of Sciences of the United States of America)

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Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations, Yan Wang, Lei Gao, Sze-Wah Tse, and Athena Andreadis (Gene)

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IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding, Maureen Wirschell, Chun Yang, Pinfen Yang, Laura Fox, Haru-aki Yanagisawa, Ritsu Kamiya, George B. Witman, Mary E. Porter, and Winfield S. Sale (Molecular biology of the cell)

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Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor, John J. Wixted, Paul J. Fanning, Tripti Gaur, Shannon L. O'Connell, Jason Silva, April Mason-Savas, David C. Ayers, Gary S. Stein, and Jane B. Lian (Journal of cellular physiology)

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A single base pair mutation encoding a premature stop codon in the MIS type II receptor is responsible for canine persistent Mullerian duct syndrome, Wenfang Wu, Shengqin Wan, Pujar Shashikant, Mark E. Haskins, Donald H. Schlafer, Mary M. Lee, and Vicki N. Meyers-Wallen (Journal of andrology)

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Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network, Sayyed K. Zaidi, Christopher R. Dowdy, Andre J. Van Wijnen, Jane B. Lian, Azra Raza, Janet L. Stein, Carlo M. Croce, and Gary S. Stein (Cancer research)

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Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response, Xinna Zhang, Lin Lin, Huarong Guo, Jianhua Yang, Stephen N. Jones, Aart Jochemsen, and Xiongbin Lu (Cancer research)

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The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells, Ying Zhang, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular biochemistry)

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Analysis of tarantula skeletal muscle protein sequences and identification of transcriptional isoforms, Jingui Zhu, Yongqiao Sun, Fa-Qing Zhao, Jun Hu, Roger W. Craig, and Songnian Hu (BMC genomics)

Submissions from 2008

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Three-dimensional reconstruction of tarantula myosin filaments suggests how phosphorylation may regulate myosin activity, Lorenzo Alamo, Willy Wriggers, Antonio Pinto, Fulvia Bartoli, Leiria Salazar, Fa-Qing Zhao, Roger W. Craig, and Raul Padron (Journal of molecular biology)

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Phenotypic transcription factors epigenetically mediate cell growth control, Syed A. Ali, Sayyed K. Zaidi, Caroline S. Dacwag, Nunciada Salma, Daniel W. Young, A. Rauf Shakoori, Martin A. Montecino, Jane B. Lian, Andre J. Van Wijnen, Anthony N. Imbalzano, Gary S. Stein, and Janet L. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism, Rami I. Aqeilan, Mohammad Q. Hassan, Alain de Bruin, John P. Hagan, Stefano Volinia, Titziana Palumbo, Sadiq Hussain, Suk Hee Lee, Tripti Gaur, Gary S. Stein, Jane B. Lian, and Carlo M. Croce (The Journal of biological chemistry)

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The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes, Rachit Bakshi, Sayyed K. Zaidi, Sandhya Pande, Mohammad Q. Hassan, Daniel W. Young, Martin A. Montecino, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Journal of cell science)

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NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts, Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Paul R. Odgren, Meilheng Yang, Hajime Sasaki, and Philip Stashenko (Bone)

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ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage, Lufen Chang, Bingsen Zhou, Shuya Hu, Robin Guo, Xiyong Liu, Stephen N. Jones, and Yun Yen (Proceedings of the National Academy of Sciences of the United States of America)

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The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis, Agnes Delaunay, Kenneth D. Bromberg, Yukiko Hayashi, Massimiliano Mirabella, Denise Burch, Brian Kirkwood, Carlo Serra, May C. Malicdan, Andrew P. Mizisin, Roberta Morosetti, Aldobrando Broccolini, Ling T. Guo, Stephen N. Jones, Sergio A. Lira, Pier Lorenzo Puri, G. Diane Shelton, and Ze'ev Ronai (PloS one)

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Regulating the acrosome reaction, Harvey M. Florman, Melissa K. Jungnickel, and Keith A. Sutton (The International journal of developmental biology)

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Structural basis for the regulation of muscle contraction by troponin and tropomyosin, Agnieszka Galinska-Rakoczy, Patti Engel, Chen Xu, HyunSuk Jung, Roger W. Craig, Larry S. Tobacman, and William Lehman (Journal of molecular biology)

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Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells, Kerri L. George, Laura H. Saltman, Gary S. Stein, Jane B. Lian, and Robert B. Zurier (Journal of cellular physiology)

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The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice, John C. Gill, Brandon Wadas, Peilin Chen, Wendy Portillo, Andrea Reyna, Elisa Jorgensen, Shaila Mani, Gerald A. Schwarting, Suzanne M. Moenter, Stuart A. Tobet, and Ursula B. Kaiser (Endocrinology)

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X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected, Lisa L. Hall, Meg Byron, John T. Butler, Klaus A. Becker, Angel Nelson, Michal Amit, Joseph Itskovitz-Eldor, Janet L. Stein, Gary S. Stein, Carol Ware, and Jeanne B. Lawrence (Journal of cellular physiology)

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Association of blood lead levels with onset of puberty in Russian boys, Russ Hauser, Oleg Sergeyev, Susan Korrick, Mary M. Lee, Boris Revich, Elana Gitin, Jane S. Burns, and Paige L. Williams (Environmental health perspectives)

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Mammalian SNM1 is required for genome stability, A. W. Hemphill, D. Bruun, L. Thrun, Y. Akkari, Y. Torimaru, K. Hejna, P. M. Jakobs, J. Hejna, Stephen N. Jones, S. B. Olson, and R. E. Moses (Molecular genetics and metabolism)

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Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal, Amjad Javed, Jong-Sup Bae, Faiza Afzal, Soraya E. Gutierrez, Jitesh Pratap, Sayyed K. Zaidi, Yang Lou, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (The Journal of biological chemistry)

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Ca2+ -induced tropomyosin movement in scallop striated muscle thin filaments, HyunSuk Jung and Roger W. Craig (Journal of molecular biology)

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Head-head and head-tail interaction: a general mechanism for switching off myosin II activity in cells, HyunSuk Jung, Satoshi Komatsu, Mitsuo Ikebe, and Roger W. Craig (Molecular biology of the cell)

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Intravascular uptake during fluoroscopically guided cervical interlaminar steroid injection at C6-7: a case report, Mark S. Kaplan, Joseph Cunniff, John Cooke, and Jeremy Giere Collins (Archives of physical medicine and rehabilitation)

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Binding of ATP to UAP56 is necessary for mRNA export, Krishna P. Kota, Stefan R. Wagner, Elvira Huerta, Jean. M. Underwood, and Jeffrey A. Nickerson (Journal of cell science)