Title

Mitotic bookmarking of genes: a novel dimension to epigenetic control

UMMS Affiliation

Department of Cell Biology and Cancer Center

Date

7-16-2010

Document Type

Article

Subjects

Epigenesis, Genetic; Mitosis; Phenotype; Transcription Factors; Histones; DNA Methylation

Abstract

Regulatory machinery is focally organized in the interphase nucleus. The information contained in these focal nuclear microenvironments must be inherited during cell division to sustain physiologically responsive gene expression in progeny cells. Recent results suggest that focal mitotic retention of phenotypic transcription factors at promoters together with histone modifications and DNA methylation--a mechanism collectively known as gene bookmarking--is a novel parameter of inherited epigenetic control that sustains cellular identity after mitosis. The epigenetic signatures imposed by bookmarking poise genes for activation or suppression following mitosis. We discuss the implications of phenotypic transcription factor retention on mitotic chromosomes in biological control and disease.

Rights and Permissions

Citation: Nat Rev Genet. 2010 Aug;11(8):583-9. Epub 2010 Jul 13. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

20628351

Journal Title

Nature reviews. Genetics