Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer
Department of Cell Biology
Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; *Epigenesis, Genetic; Gene Expression; Humans; Mitosis; Transcription Factors; Transcription, Genetic
There is growing awareness that the fidelity of gene expression necessitates coordination of transcription factor metabolism and organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture. The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis. High throughput imaging of cells, tissues, and tumors, including live cell analysis, is expanding research's capabilities toward translating components of nuclear organization into novel strategies for cancer diagnosis and therapy.
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Citation: Ann N Y Acad Sci. 2009 Feb;1155:4-14. Link to article on publisher's site
Annals of the New York Academy of Sciences