Title

Nuclear microenvironments and cancer

UMMS Affiliation

Department of Cell Biology

Date

7-24-2008

Document Type

Article

Subjects

Cell Nucleus; Epigenesis, Genetic; Humans; Neoplasms

Abstract

Nucleic acids and regulatory proteins are architecturally organized in nuclear microenvironments. The compartmentalization of regulatory machinery for gene expression, replication and repair, is obligatory for fidelity of biological control. Perturbations in the organization, assembly and integration of regulatory machinery have been functionally linked to the onset and progression of tumorigenesis. The combined application of cellular, molecular, biochemical and in vivo genetic approaches, together with structural biology, genomics, proteomics and bioinformatics, will likely lead to new approaches in cancer diagnostics and therapy.

Rights and Permissions

Citation: J Cell Biochem. 2008 Aug 15;104(6):1949-52. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal Title

Journal of cellular biochemistry

PubMed ID

18649350