The Chlamydomonas genome reveals the evolution of key animal and plant functions
Authors
Merchant, Sabeeha S.Prochnik, Simon E.
Witman, George B.
Pazour, Gregory J.
Rokhsar, Daniel S.
Grossman, Arthur R.
Document Type
Journal ArticlePublication Date
2007-10-13Keywords
Algal ProteinsAnimals
Chlamydomonas reinhardtii
Chloroplasts
Computational Biology
DNA, Algal
*Evolution
Flagella
Genes
*Genome
Genomics
Membrane Transport Proteins
Molecular Sequence Data
Multigene Family
Photosynthesis
Phylogeny
Plants
Proteome
Sequence Analysis, DNA
Cell Biology
Metadata
Show full item recordAbstract
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the approximately 120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.Source
Science. 2007 Oct 12;318(5848):245-50. Link to article on publisher's siteDOI
10.1126/science.1143609Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26534PubMed ID
17932292Notes
See the article on publisher's site or in PubMed Central for the full list of authors.Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1126/science.1143609