Title
Intraflagellar transport
UMMS Affiliation
Department of Cell Biology
Date
11-5-2002
Document Type
Article
Subjects
Animals; Biological Transport; Cilia; Flagella; Humans; Polycystic Kidney Diseases; Retinal Degeneration; Signal Transduction
Abstract
Eukaryotic cilia and flagella, including primary cilia and sensory cilia, are highly conserved organelles that project from the surfaces of many cells. The assembly and maintenance of these nearly ubiquitous structures are dependent on a transport system--known as 'intraflagellar transport' (IFT)--which moves non-membrane-bound particles from the cell body out to the tip of the cilium or flagellum, and then returns them to the cell body. Recent results indicate that defects in IFT might be a primary cause of some human diseases.
Rights and Permissions
Citation: Nat Rev Mol Cell Biol. 2002 Nov;3(11):813-25. Link to article on publisher's site
Related Resources
PubMed ID
12415299
Journal Title
Nature reviews. Molecular cell biology