Publications from 2012
Role of JNK in mammary gland development and breast cancer, Cristina Arrigo Cellurale, Nomeda Girnius, Feng Jiang, Julie Cavanagh-Kyros, Shaolei Lu, David S. Garlick, Arthur M. Mercurio, and Roger J. Davis
Integrin beta4 regulates SPARC protein to promote invasion, Kristin D. Gerson, Jeffrey R. Shearstone, V.S.R. Krishna Maddula, Bruce E. Seligmann, and Arthur M. Mercurio
VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer, Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav, Stephen Lyle, Hualin Simon Xi, Chung-Cheng Hsieh, Helty Adisetiyo, Pradip Roy-Burman, Ilsa M. Coleman, Peter S. Nelson, Robert L. Vessella, Roger J. Davis, Stephen R. Plymate, and Arthur M. Mercurio
Enhancing integrin function by VEGF/neuropilin signaling: Implications for tumor biology, Hira Lal Goel and Arthur M. Mercurio
Neuropilin-2 regulates alpha6beta1 integrin in the formation of focal adhesions and signaling, Hira Lal Goel, Bryan M. Pursell, Clive Standley, Kevin E. Fogarty, and Arthur M. Mercurio
Paternal RLIM/Rnf12 Is a Survival Factor for Milk-Producing Alveolar Cells, Baowei Jiao, Hong Ma, Maxim N. Shokhirev, Alexander Drung, Qin Yang, JongDae Shin, Shaolei Lu, Meg Byron, Sundeep Kalantry, Arthur M. Mercurio, Jeanne B. Lawrence, Alexander Hoffmann, and Ingolf Bach
Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways, Miroslav Koulnis, Ermelinda Porpiglia, P. Alberto Porpiglia, Ying Liu, Kelly N. Hallstrom, Daniel Hidalgo, and Merav Socolovsky
Cooperativity of Rb, Brca1, and p53 in malignant breast cancer evolution, Prashant Kumar, Malini Mukherjee, Jacob P. S. Johnson, Milan Patel, Bing Huey, Donna G. Albertson, and Karl Simin
Slow-cycling therapy-resistant cancer cells, Nathan F. Moore, JeanMarie Houghton, and Stephen Lyle
Stat5 Signaling Specifies Basal versus Stress Erythropoietic Responses through Distinct Binary and Graded Dynamic Modalities, Ermelinda Porpiglia, Daniel Hidalgo, Miroslav Koulnis, Abraham R. Tzafriri, and Merav Socolovsky
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis, Mihir Rajurkar, Wilfredo E. De Jesus-Monge, David R. Driscoll, Victoria A. Appleman, He Huang, Jennifer L. Cotton, David S. Klimstra, Lihua Julie Zhu, Karl Simin, Lan Xu, Andrew P. McMahon, Brian C. Lewis, and Junhao Mao
Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia, Haojian Zhang, Huawei Li, Ngoc Ho, Dongguang Li, and Shaoguang Li
HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells, Haojian Zhang, Huawei Li, Hualin S. Xi, and Shaoguang Li
Publications from 2011
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression, Camilla Frohlich, Camilla Nehammer, Reidar Albrechtsen, Pauliina Kronqvist, Marie Kveiborg, Atsuko Sehara-Fujisawa, Arthur M. Mercurio, and Ulla M. Wewer
Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin, Hugh S. Gannon, Lawrence A. Donehower, Stephen Lyle, and Stephen N. Jones
Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland, Hira Lal Goel, Donggoo Bae, Bryan M. Pursell, Lindsey M. Gouvin, Shaolei Lu, and Arthur M. Mercurio
Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease, Byoung H. Kang, M. Tavecchio, Hira Lal Goel, Chung-Cheng Hsieh, David S. Garlick, Christopher M. Raskett, Jane B. Lian, Gary S. Stein, Lucia R. Languino, and Dario C. Altieri
IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer, Di Lu, Xiaofang Yang, Naomi Y. Jiang, Bruce A. Woda, Qin Liu, Karen A. Dresser, Arthur M. Mercurio, Kenneth L. Rock, and Zhong Jiang
Global DNA demethylation during mouse erythropoiesis in vivo, Jeffrey R. Shearstone, Ramona Pop, Christoph Bock, Patrick Boyle, Alexander Meissner, and Merav Socolovsky
Functional ramifications for the loss of P-selectin expression on hematopoietic and leukemic stem cells, Con Sullivan, Yaoyu Chen, Yi Shan, Yiguo Hu, Cong Peng, Haojian Zhang, Linghong Kong, and Shaoguang Li
Publications from 2010
Transcriptional regulation of VEGF-A by the unfolded protein response pathway, Rajarshi Ghosh, Kathryn L. Lipson, Karen E. Sargent, Arthur M. Mercurio, Joan S. Hunt, David Ron, and Fumihiko Urano
p53 represses class switch recombination to IgG2a through its antioxidant function, Jeroen E. J. Guikema, Carol E. Schrader, Michael H. Brodsky, Erin K. Linehan, Adam Richards, Nahla El Falaky, Daniel H. LI, Hayla Karen Sluss, Eva Szomolanyi-Tsuda, and Janet Stavnezer
Pregnancy modulates precursor cell proliferation in a murine model of focal demyelination, Shirin Haddady, Hoi Pang Low, Susan Billings-Gagliardi, Peter N. Riskind, and William J. Schwartz
Mutations in bone marrow-derived stromal stem cells unmask latent malignancy, JeanMarie Houghton, Hanchen Li, Xueli Fan, Yingwang Liu, Jian Hua Liu, Varada P. Rao, Theofilos Poutahidis, Christine L. Taylor, Erin A. Jackson, Christine Hewes, Stephen Lyle, Anna M. Cerny, Glennice N. Bowen, Jan Cerny, Nathan F. Moore, Evelyn A. Kurt-Jones, and Susan E. Erdman
Identification of accrual barriers onto breast cancer prevention clinical trials: a case-control study, Robert H. Houlihan, Michael H. Kennedy, Robert R. Kulesher, Stephenie C. Lemon, D. Lawrence Wickerham, Chung-Cheng Hsieh, and Dario C. Altieri
AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1, Shinsuke Ishigaki, Sonya G. Fonseca, Christine M. Oslowski, Agata Jurczyk, Jeffrey R. Shearstone, Lihua Julie Zhu, M. A. Permutt, Dale L. Greiner, Fumihiko Urano, and Rita Bortell
ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading, Paul Mak, Irwin Leav, Bryan M. Pursell, Donggoo Bae, Xiaofang Yang, Cherie A. Taglienti, Lindsey M. Gouvin, Vishva Mitra Sharma, and Arthur M. Mercurio
Activation of autophagy during cell death requires the engulfment receptor Draper, Christina K. McPhee, Mary A. Logan, Marc R. Freeman, and Eric H. Baehrecke
IAP regulation of metastasis, Swarna Mehrotra, Lucia R. Languino, Christopher M. Raskett, Arthur M. Mercurio, Takehiko Dohi, and Dario C. Altieri
miR-10b targets Tiam1: implications for Rac activation and carcinoma migration, Charlotte M. Harwood Moriarty, Bryan M. Pursell, and Arthur M. Mercurio
A Key Commitment Step in Erythropoiesis Is Synchronized with the Cell Cycle Clock through Mutual Inhibition between PU.1 and S-Phase Progression, Ramona Pop, Jeffrey R. Shearstone, Qichang Shen, Ying Liu, Kelly N. Hallstrom, Miroslav Koulnis, Joost Gribnau, and Merav Socolovsky
Therapeutic targeting of C-terminal binding protein in human cancer, Michael W. Straza, Seema Paliwal, Ramesh C. Kovi, Barur R. Rajeshkumar, Peter Trenh, Daniel Parker, Giles F. Whalen, Stephen Lyle, Celia A. Schiffer, and Steven R. Grossman
Publications from 2009
Autophagy SEPArates germline and somatic cells, Eric H. Baehrecke
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia, Yaoyu Chen, Yiguo Hu, Haojian Zhang, Cong Peng, and Shaoguang Li
Targeting the Notch1 and mTOR pathways in a mouse T-ALL model, Kathleen Cullion, Kyle M. Draheim, Nicole M. Hermance, Jennifer Tammam, Vishva Mitra Sharma, Christopher Ware, George Nikov, Veena Krishnamoorthy, Pradip K. Majumder, and Michelle A. Kelliher
Occam's dull razor: MDM2 and P/CAF keep Chk2 in check the hard way, Steven R. Grossman
Expression and function of the insulin receptor substrate proteins in cancer, Katerina Mardilovich, Shannon L. Pankratz, and Leslie M. Shaw
The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells, Samisubbu R. Naidu, Ian M. Love, Anthony N. Imbalzano, Steven R. Grossman, and Elliot J. Androphy
NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis, Amit K. Pandey, Yibin Yang, Zhaozhao Jiang, Sarah M. Fortune, Francois Coulombe, Marcel A. Behr, Katherine A. Fitzgerald, Christopher M. Sassetti, and Michelle A. Kelliher
PTEN is a tumor suppressor in CML stem cells and BCR-ABL induced leukemias in mice., Cong Peng, Yaoyu Chen, Zhongfa Yang, Haojian Zhang, Lori Osterby, Alan G. Rosmarin, and Shaoguang Li
The hair follicle barrier to involvement by malignant melanoma, Olga Pozdnyakova, Joseph Grossman, Belinda Barbagallo, and Stephen Lyle
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53, Dingding Shi, Marius S. Pop, Roman Kulikov, Ian M. Love, Andrew L. Kung, and Steven R. Grossman
Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition, Xiaofang Yang, Bryan Pursell, Shaolei Lu, Tsun-Kai Chang, and Arthur M. Mercurio
Publications from 2008
New wirings in the survivin networks, Dario C. Altieri
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2, Donggoo Bae, Shaolei Lu, Cherie A. Taglienti, and Arthur M. Mercurio
Integrins in prostate cancer progression, Hira Lal Goel, Jing Li, Sophia Kogan, and Lucia R. Languino
Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis, Connie Wing-Ching Lee, Christopher M. Raskett, Igor Prudovsky, and Dario C. Altieri
A functional Notch-survivin gene signature in basal breast cancer, Connie Wing-Ching Lee, Karl Simin, Qin Liu, Janet Plescia, Minakshi Guha, Ashraf Khan, Chung-Cheng Hsieh, and Dario C. Altieri
BRCA-FA pathway as a target for anti-tumor drugs, Rachel Litman, Rigu Gupta, Robert M. Brosh, and Sharon B. Cantor
Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance, Shaolei Lu, Karl Simin, Ashraf Khan, and Arthur M. Mercurio
Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells, Rajini R. Mudhasani, Zhiqing Zhu, Gyorgy Hutvagner, Christine M. Eischen, Stephen Lyle, Lisa L. Hall, Jeanne B. Lawrence, Anthony N. Imbalzano, and Stephen N. Jones
Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1, Shannon L. Pankratz, Ernest Y. Tan, Yumiko Fine, Arthur M. Mercurio, and Leslie M. Shaw
A survivin-ran complex regulates spindle formation in tumor cells, Fang Xia, Pedro Canovas, Thomas M. Guadagno, and Dario C. Altieri
Tumor cell dependence on Ran-GTP-directed mitosis, Fang Xia, Connie Wing-Ching Lee, and Dario C. Altieri
Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses, Shenghua Zhou, Annett Halle, Evelyn A. Kurt-Jones, Anna M. Cerny, Ermelinda Porpiglia, Michael Rogers, Douglas Golenbock, and Robert W. Finberg
Publications from 2007
Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells, Richard C. Bates, Bryan M. Pursell, and Arthur M. Mercurio
The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function, Valentina Folgiero, Robin E. Bachelder, Guilia Bon, Ada Sacchi, Rita Falcioni, and Arthur M. Mercurio
Hsp60 regulation of tumor cell apoptosis, Jagadish C. Ghosh, Takehiko Dohi, Byoung Kang, and Dario C. Altieri
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein, Rigu Gupta, Sudha Sharma, Joshua A. Sommers, Mark K. Kenny, Sharon B. Cantor, and Robert M. Brosh
Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice, Hanchen Li, Xueli Fan, Ramesh C. Kovi, YunJu Jo, Brian Moquin, Richard Konz, Calin Stoicov, Evelyn A. Kurt-Jones, Steven R. Grossman, Stephen Lyle, Arlin B. Rogers, Marshall Montrose, and JeanMarie Houghton
Intrinsic signaling functions of the beta4 integrin intracellular domain, Keith D. Merdek, Xiaoqing Yang, Cherie A. Taglienti, Leslie M. Shaw, and Arthur M. Mercurio
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells, Min Peng, Rachel Litman, Jenny X. Xie, Sudha Sharma, Robert M. Brosh, and Sharon B. Cantor
Negative autoregulation by FAS mediates robust fetal erythropoiesis, Merav Socolovsky, Michael Murrell, Ying Liu, Ramona Pop, Ermelinda Porpiglia, and Andre Levchenko
Publications from 2006
Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma, David I. Bellovin, Kaylene J. Simpson, T. Danilov, Elizabeth Maynard, David L. Rimm, Peter Oettgen, and Arthur M. Mercurio
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes, Roger A. Greenberg, Bijan Sobhian, Shailja Pathania, Sharon B. Cantor, Yoshihiro Nakatani, and David M. Livingston
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand, Rigu Gupta, Sudha Sharma, Kevin M. Doherty, Joshua A. Sommers, Sharon B. Cantor, and Robert M. Brosh
Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH, Anastasiya Kazantseva, Andrey Goltsov, Rena A. Zinchenko, Anastasia P. Grigorenko, Anna V. Abrukova, Yuri K. Moliaka, Alexander G. Kirillov, Zhiru Guo, Stephen Lyle, Evgeny K. Ginter, and Evgeny I. Rogaev
Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers, Hanchen Li, Calin Stoicov, Arlin B. Rogers, and JeanMarie Houghton
Non-angiogenic functions of VEGF in breast cancer, Arthur M. Mercurio, Elizabeth A. Lipscomb, and Robin E. Bachelder
BACH1 is a DNA repair protein supporting BRCA1 damage response, Min Peng, Rachel Litman, Zhe Jin, G. Fong, and Sharon B. Cantor
Dynamic Functions of the α6β4 Integrin in Carcinoma, Isaac Rabinovitz and Arthur M. Mercurio
Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc, Vishva Mitra Sharma, Jennifer Ann Calvo, Kyle M. Draheim, Leslie A. Cunningham, Nicole M. Hermance, Levi J. Beverly, Veena Krishnamoorthy, Manoj Bhasin, Anthony J. Capobianco, and Michelle A. Kelliher
Bone marrow cells as the origin of stomach cancer, Calin Stoicov, Hanchen Li, Jane E. Carlson, and JeanMarie Houghton
Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells, Sang-oh Yoon, Sejeong Shin, and Arthur M. Mercurio
Publications from 2005
Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition, Robin E. Bachelder, Sang-oh Yoon, Clara Franci, Antonio Garcia de Herreros, and Arthur M. Mercurio
Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma, Richard C. Bates, David I. Bellovin, Courtney Brown, Elizabeth Maynard, Bingyan Wu, Hisaaki Kawakatsu, Dean Sheppard, Peter Oettgen, and Arthur M. Mercurio
The epithelial-mesenchymal transition (EMT) and colorectal cancer progression, Richard C. Bates and Arthur M. Mercurio
Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease, David I. Bellovin, Richard C. Bates, Alona Muzikansky, David L. Rimm, and Arthur M. Mercurio
Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice, Xun Cai, Jane E. Carlson, Calin Stoicov, Hanchen Li, Timothy C. Wang, and JeanMarie Houghton
Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB, Baskaran Govindarajan, Asha Shah, Cynthia Cohen, Rebecca S. Arnold, Jeffrey Schechner, Jun Chung, Arthur M. Mercurio, Rhoda Alani, Byungwoo Ryu, Chun-Yang Fan, Jose M. Cuezva, Marta Martinez, and Jack L. Artbiser
Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission, Adam Scott Gromley, Charles Yeaman, Jack Rosa, Sambra D. Redick, Chun-Ting Chen, Stephanie Mirabelle, Minakshi Guha, James Sillibourne, and Stephen J. Doxsey
Cortical actin turnover during cytokinesis requires myosin II, Minakshi Guha, Mian Zhou, and Yu-Li Wang
Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer, Rigu Gupta, Sudha Sharma, Joshua A. Sommers, Zhe Jin, Sharon B. Cantor, and Robert M. Brosh
A role for ADAM12 in breast tumor progression and stromal cell apoptosis, Marie Kveiborg, Camilla Frohlich, Reidar Albrechtsen, Verena Tischler, Nikolaj Dietrich, Peter Holck, Pauliina Kronqvist, Fritz Rank, Arthur M. Mercurio, and Ulla M. Wewer
Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression, Elizabeth A. Lipscomb and Arthur M. Mercurio
The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo, Elizabeth A. Lipscomb, Kaylene J. Simpson, Stephen Lyle, Jennifer E. Ring, Aisling S. Dugan, and Arthur M. Mercurio
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ, Rachel Litman, Min Peng, Zhe Jin, Fan Zhang, Junran Zhang, Simon N. Powell, Paul R. Andreassen, and Sharon B. Cantor
Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation, Calin Stoicov, Xun Cai, Hanchen Li, Kristine Klucevsek, Jane E. Carlson, Reza Saffari, and JeanMarie Houghton
Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin, Sang-oh Yoon, Sejeong Shin, and Arthur M. Mercurio
Publications from 2004
The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis, Richard C. Bates, Michael J. DeLeo III, and Arthur M. Mercurio
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations, Sharon B. Cantor, Ronny Drapkin, Fan Zhang, Yafang Lin, Juliana Han, Sushmita Pamidi, and David M. Livingston
Contributions of the alpha6 integrins to breast carcinoma survival and progression, Jun Chung and Arthur M. Mercurio
Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells, Jun Chung, Sangoh Yoon, Kaustubh Datta, Robin E. Bachelder, and Arthur M. Mercurio
The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion, Jun Chung, Sang-oh Yoon, Elizabeth A. Lipscomb, and Arthur M. Mercurio
Proteases, extracellular matrix, and cancer: a workshop of the path B study section, Yves A. DeClerck, Arthur M. Mercurio, M. Sharon Stack, Harold D. Chapman, Mary M. Zutter, Ruth J. Muschel, Avraham Raz, Lynn M. Matrisian, Bonnie F. Sloane, Agnes Noel, Mary J. Hendrix, Lisa Coussens, and Martin Padarathsingh
Gastric cancer originating from bone marrow-derived cells, JeanMarie Houghton, Calin Stoicov, Sachiyo Nomura, Arlin B. Rogers, Jane E. Carlson, Hanchen Li, Xun Cai, James G. Fox, James R. Goldenring, and Timothy C. Wang
The Rho GTPase in Tumor Invasion, Arthur M. Mercurio
Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin, Arthur M. Mercurio, Robin E. Bachelder, Richard C. Bates, and Jun Chung
Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes, Isaac Rabinovitz, Lobsang Tsomo, and Arthur M. Mercurio
Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma, Kaylene J. Simpson, Aisling S. Dugan, and Arthur M. Mercurio
