This collection showcases journal articles and other publications and presentations written by faculty and researchers in the Department of Cancer Biology at the University of Massachusetts Medical School.

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Publications from 2005

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The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo, Elizabeth A. Lipscomb, Kaylene J. Simpson, Stephen Lyle, Jennifer E. Ring, Aisling S. Dugan, and Arthur M. Mercurio

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BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ, Rachel Litman, Min Peng, Zhe Jin, Fan Zhang, Junran Zhang, Simon N. Powell, Paul R. Andreassen, and Sharon B. Cantor

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Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation, Calin Stoicov, Xun Cai, Hanchen Li, Kristine Klucevsek, Jane E. Carlson, Reza Saffari, and JeanMarie Houghton

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Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin, Sang-oh Yoon, Sejeong Shin, and Arthur M. Mercurio

Publications from 2004

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The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis, Richard C. Bates, Michael J. DeLeo III, and Arthur M. Mercurio

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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations, Sharon B. Cantor, Ronny Drapkin, Fan Zhang, Yafang Lin, Juliana Han, Sushmita Pamidi, and David M. Livingston

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Contributions of the alpha6 integrins to breast carcinoma survival and progression, Jun Chung and Arthur M. Mercurio

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Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells, Jun Chung, Sangoh Yoon, Kaustubh Datta, Robin E. Bachelder, and Arthur M. Mercurio

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The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion, Jun Chung, Sang-oh Yoon, Elizabeth A. Lipscomb, and Arthur M. Mercurio

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Proteases, extracellular matrix, and cancer: a workshop of the path B study section, Yves A. DeClerck, Arthur M. Mercurio, M. Sharon Stack, Harold D. Chapman, Mary M. Zutter, Ruth J. Muschel, Avraham Raz, Lynn M. Matrisian, Bonnie F. Sloane, Agnes Noel, Mary J. Hendrix, Lisa Coussens, and Martin Padarathsingh

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Gastric cancer originating from bone marrow-derived cells, JeanMarie Houghton, Calin Stoicov, Sachiyo Nomura, Arlin B. Rogers, Jane E. Carlson, Hanchen Li, Xun Cai, James G. Fox, James R. Goldenring, and Timothy C. Wang

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The Rho GTPase in Tumor Invasion, Arthur M. Mercurio

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Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin, Arthur M. Mercurio, Robin E. Bachelder, Richard C. Bates, and Jun Chung

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Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes, Isaac Rabinovitz, Lobsang Tsomo, and Arthur M. Mercurio

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Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma, Kaylene J. Simpson, Aisling S. Dugan, and Arthur M. Mercurio

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Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling, Calin Stoicov, Reza Saffari, Xun Cai, Chhaya Hasyagar, and JeanMarie Houghton

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Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections, Calin Stoicov, Mark T. Whary, Arlin B. Rogers, Frederick S. Lee, Kristine Klucevsek, Hanchen Li, Xun Cai, Reza Saffari, Zhongming Ge, Imtiaz A. Khan, Crescent L. Combe, Andrew D. Luster, James G. Fox, and JeanMarie Houghton

Publications from 2003

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Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells, Robin E. Bachelder, Elizabeth A. Lipscomb, Xuena Lin, Melissa A. Wendt, Neil H. Chadborn, Britta J. Eickholt, and Arthur M. Mercurio

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Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids, Richard C. Bates, Jeffrey D. Goldsmith, Robin E. Bachelder, Courtney Brown, Masabumi Shibuya, Peter Oettgen, and Arthur M. Mercurio

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Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids, Richard C. Bates and Arthur M. Mercurio

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ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function, Nobuko Kawaguchi, Christina Sundberg, Marie Kveiborg, Behzad Moghadaszadeh, Meena Asmar, Nikolaj Dietrich, Charles Kumar Thodeti, Finn C. Nielsen, Peter Moller, Arthur M. Mercurio, Reidar Albrechtsen, and Ulla M. Wewer

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Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility, Hanchen Li, Calin Stoicov, Xun Cai, Timothy C. Wang, and JeanMarie Houghton

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Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells, Elizabeth A. Lipscomb, Aisling S. Dugan, Isaac Rabinovitz, and Arthur M. Mercurio

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Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way, Arthur M. Mercurio

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ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA, Charles Kumar Thodeti, Reidar Albrechtsen, Morten Grauslund, Meena Asmar, Christer Larsson, Yoshikazu Takada, Arthur M. Mercurio, John R. Couchman, and Ulla M. Wewer

Publications from 2002

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Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4, Robin E. Bachelder, Melissa A. Wendt, and Arthur M. Mercurio

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Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells, Jun Chung, Robin E. Bachelder, Elizabeth A. Lipscomb, Leslie M. Shaw, and Arthur M. Mercurio

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Lessons from the alpha2 integrin knockout mouse, Arthur M. Mercurio

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Expression of the beta 4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells, Annarita Morena, Sabrina Riccioni, Alessandra Marchetti, Alessandro Tartaglia Polcini, Arthur M. Mercurio, Giovanni Blandino, Ada Sacchi, and Rita Falcioni

Publications from 2001

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Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells, Robin E. Bachelder, Aimee Crago, Jun Chung, Melissa A. Wendt, Leslie M. Shaw, Gregory Robinson, and Arthur M. Mercurio

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The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis, Robin E. Bachelder, Melissa A. Wendt, Naoya Fujita, Takashi Tsuruo, and Arthur M. Mercurio

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BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function, Sharon B. Cantor, Daphne W. Bell, Shridar Ganesan, Elizabeth M. Kass, Ronny Drapkin, Steven R. Grossman, Doke C. R. Wahrer, Dennis C. Sgroi, William S. Lane, Daniel A. Haber, and David M. Livingston

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Integrin laminin receptors and breast carcinoma progression, Arthur M. Mercurio, Robin E. Bachelder, Jun Chung, Kathleen L. O'Connor, Isaac Rabinovitz, Leslie M. Shaw, and Taneli Tani

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Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin, Arthur M. Mercurio and Isaac Rabinovitz

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The alpha 6 beta 4 integrin and epithelial cell migration, Arthur M. Mercurio, Isaac Rabinovitz, and Leslie M. Shaw

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Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells, Kathleen L. O'Connor and Arthur M. Mercurio

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Traction forces mediated by alpha6beta4 integrin: implications for basement membrane organization and tumor invasion, Isaac Rabinovitz, I. K. Gipson, and Arthur M. Mercurio

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PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B, Taneli Tani and Arthur M. Mercurio

Publications from 2000

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Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion, Daniela Gambaletta, Alessandra Marchetti, Laura Benedetti, Arthur M. Mercurio, Ada Sacchi, and Rita Falcioni

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Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing, Margaret M. Lotz, Isaac Rabinovitz, and Arthur M. Mercurio

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RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism, Kathleen L. O'Connor, B. K. Nguyen, and Arthur M. Mercurio

Publications from 1999

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Activation of p53 function in carcinoma cells by the alpha6beta4 integrin, Robin E. Bachelder, Alessandra Marchetti, Rita Falcioni, Silvia Soddu, and Arthur M. Mercurio

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p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB, Robin E. Bachelder, Mark J. Ribick, Alessandra Marchetti, Rita Falcioni, Silvia Soddu, Kathryn R. Davis, and Arthur M. Mercurio

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BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway, Junjie Chen, Daniel P. Silver, Sharon B. Cantor, David M. Livingston, and Ralph Scully

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Evidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM, M. S. Chen, E. A. Almeida, A. P. Huovila, Y. Takahashi, Leslie M. Shaw, Arthur M. Mercurio, and J. M. White

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Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells, Isaac Rabinovitz, Alex Toker, and Arthur M. Mercurio

Publications from 1998

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Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells, Vinicio Carloni, Roberto G. Romanelli, Arthur M. Mercurio, Massimo Pinzani, Giacomo Laffi, Giorgio Cotrozzi, and Paolo Gentilini

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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells, Junjie Chen, Daniel P. Silver, Deepika Walpita, Sharon B. Cantor, Adi F. Gazdar, Gail Tomlinson, Fergus J. Couch, Barbara L. Weber, Terry Ashley, David M. Livingston, and Ralph Scully

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Endothelial cells assemble two distinct alpha6beta4-containing vimentin-associated structures: roles for ligand binding and the beta4 cytoplasmic tail, Suzanne M. Homan, Arthur M. Mercurio, and Susan E. LaFlamme

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Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells, Kathleen L. O'Connor, Leslie M. Shaw, and Arthur M. Mercurio

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The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures, Isaac Rabinovitz and Arthur M. Mercurio

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Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion, Leslie M. Shaw, Isaac Rabinovitz, Helen H. Wang, Alex Toker, and Arthur M. Mercurio

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Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit, Jueyang Wei, Leslie M. Shaw, and Arthur M. Mercurio

Publications from 1997

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Association between sucrase-isomaltase and p53 expression in colorectal cancer, Mario Lise, Massimo Loda, Michelangelo Fiorentino, Arthur M. Mercurio, Ian C. Summerhayes, Phillip T. Lavin, and J. Milburn Jessup

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Intestinal epithelial restitution. Involvement of specific laminin isoforms and integrin laminin receptors in wound closure of a transformed model epithelium, Margaret M. Lotz, A. Nusrat, J. L. Madara, R. Ezzell, Ulla M. Wewer, and Arthur M. Mercurio

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Integrin signaling in leukocytes: lessons from the alpha6beta1 integrin, Jueyang Wei, Leslie M. Shaw, and Arthur M. Mercurio

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The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice, Ulla M. Wewer, Leslie M. Shaw, R. Albrechtsen, and Arthur M. Mercurio

Publications from 1996

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A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells, Celia Chao, Margaret M. Lotz, Andrew C. Clarke, and Arthur M. Mercurio

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Evidence for a Ras/Ral signaling cascade, Larry A. Feig, Takeshi Urano, and Sharon B. Cantor

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The integrin alpha 6 beta 4 and the biology of carcinoma, Isaac Rabinovitz and Arthur M. Mercurio

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Function of the integrin alpha 6 beta 1 in metastatic breast carcinoma cells assessed by expression of a dominant-negative receptor, Leslie M. Shaw, Celia Chao, Ulla M. Wewer, and Arthur M. Mercurio

Publications from 1995

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Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor, Eduardo A. C. Almeida, A. P.J. Huovila, A. E. Sutherland, L. E. Stephens, P. G. Calarco, Leslie M. Shaw, Arthur M. Mercurio, A. Sonnenberg, P. Primakoff, D. G. Myles, and J. M. White

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Role of the E-cadherin/alpha-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells, Ellen C. Breen, Glenn D. Steele Jr., and Arthur M. Mercurio

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Role of E-cadherin in the response of tumor cell aggregates to lymphatic, venous and arterial flow: measurement of cell-cell adhesion strength, Stephen W. Byers, Connie L. Sommers, Becky Hoxter, Arthur M. Mercurio, and Aydin Tozeren

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Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases, Sharon B. Cantor, Takeshi Urano, and Larry A. Feig

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Activation of the p21 pathway of growth arrest and apoptosis by the beta 4 integrin cytoplasmic domain, Astrid S. Clark, Margaret M. Lotz, Celia Chao, and Arthur M. Mercurio

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Sucrase-isomaltase is an independent prognostic marker for colorectal carcinoma, J. Milburn Jessup, Phillip T. Lavin, Charles W. Andrews Jr., Massimo Loda, Arthur M. Mercurio, B. D. Minsky, C. Mies, B. Cukor, R. Bleday, and Glenn D. Steele Jr.

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Laminin receptors: achieving specificity through cooperation, Arthur M. Mercurio

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The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins, Leslie M. Shaw, Christopher E. Turner, and Arthur M. Mercurio

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E-selectin-mediated dynamic interactions of breast- and colon-cancer cells with endothelial-cell monolayers, Aydin Tozeren, Hynda K. Kleinman, Derrick S. Grant, David Morales, Arthur M. Mercurio, and Stephen W. Byers

Publications from 1994

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Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages, Leslie M. Shaw and Arthur M. Mercurio

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Integrin alpha 6 beta 4 mediates dynamic interactions with laminin, Aydin Tozeren, Hynda K. Kleinman, Stephen Wu, Arthur M. Mercurio, and Stephen W. Byers

Publications from 1993

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Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma, Margaret M. Lotz, Charles W. Andrews Jr., Cynthia A. Korzelius, Edward C. Lee, Glenn D. Steele Jr., Astrid Clarke, and Arthur M. Mercurio

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Fimbrin localized to an insoluble cytoskeletal fraction is constitutively phosphorylated on its headpiece domain in adherent macrophages, Jeanne M. Messier, Leslie M. Shaw, M. Chafel, Paul Matsudaira, and Arthur M. Mercurio

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Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line, Leslie M. Shaw, Margaret M. Lotz, and Arthur M. Mercurio

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Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit, Leslie M. Shaw and Arthur M. Mercurio

Publications from 1992

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Sucrase-isomaltase expression in chronic ulcerative colitis and dysplasia, Charles W. Andrews Jr., Carl J. O'Hara, Harvey Goldman, Arthur M. Mercurio, Mark L. Silverman, and Glenn D. Steele Jr.

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The integrin alpha 6 beta 4 is a laminin receptor, Edward C. Lee, Margaret M. Lotz, Glenn D. Steele Jr., and Arthur M. Mercurio

Publications from 1991

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Carbohydrate-binding protein 35 is the major cell-surface laminin-binding protein in colon carcinoma, Edward C. Lee, Hee-Jong Woo, Cynthia A. Korzelius, Glenn D. Steele Jr., and Arthur M. Mercurio

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Laminin binding proteins, Arthur M. Mercurio and Leslie M. Shaw

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Carbohydrate-binding protein 35 (Mac-2), a laminin-binding lectin, forms functional dimers using cysteine 186, Hee-Jong Woo, Margaret M. Lotz, Jae U. Jung, and Arthur M. Mercurio

Publications from 1990

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Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of alpha 6 beta 4 and alpha 2 beta 1 integrins, Margaret M. Lotz, Cynthia A. Korzelius, and Arthur M. Mercurio

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Laminin: multiple forms, multiple receptors, Arthur M. Mercurio

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The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin, Leslie M. Shaw, Jeanne M. Messier, and Arthur M. Mercurio

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The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2), Hee-Jong Woo, Leslie M. Shaw, Jeanne M. Messier, and Arthur M. Mercurio

Publications from 1989

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Relationship between extracellular matrix interactions and degree of differentiation in human colon carcinoma cell lines, George W. Daneker Jr., Andrea J. Piazza, Glenn D. Steele Jr., and Arthur M. Mercurio

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Interferon gamma and lipopolysaccharide promote macrophage adherence to basement membrane glycoproteins, Leslie M. Shaw and Arthur M. Mercurio

Publications from 1988

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Macrophage interactions with laminin: PMA selectively induces the adherence and spreading of mouse macrophages on a laminin substratum, Arthur M. Mercurio and Leslie M. Shaw

Publications from 1987

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Laminin expression in colorectal carcinomas varying in degree of differentiation, George W. Daneker Jr., Arthur M. Mercurio, Lisa Guerra, Barbara Wolf, Ronald R. Salem, Darius J. Bagli, and Glenn D. Steele Jr.

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Modulation of two distinct galactosyltransferase activities in populations of mouse peritoneal macrophages, Bradley T. Sheares and Arthur M. Mercurio

Publications from 1986

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Disruption of oligosaccharide processing in murine tumor cells inhibits their susceptibility to lysis by activated mouse macrophages, Arthur M. Mercurio

Publications from 1985

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Activation of mouse peritoneal macrophages alters the structure and surface expression of protein-bound lactosaminoglycans, Arthur M. Mercurio and Phillips W. Robbins

Publications from 1984

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Glycolipids of the mouse peritoneal macrophage. Alterations in amount and surface exposure of specific glycolipid species occur in response to inflammation and tumoricidal activation, Arthur M. Mercurio, Gerald A. Schwarting, and Phillips W. Robbins

Publications from 1982

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Smooth endoplasmic reticulum and other agranular reticulum in frog retinal photoreceptors, Arthur M. Mercurio and Eric Holtzman

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Ultrastructural localization of glycerolipid synthesis in rod cells of the isolated frog retina, Arthur M. Mercurio and Eric Holtzman

Publications from 1980

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Membrane circulation in neurons and photoreceptors: some unresolved issues, Eric Holtzman and Arthur M. Mercurio