Title

Evidence for a Ras/Ral signaling cascade

UMMS Affiliation

Department of Cancer Biology

Date

11-1-1996

Document Type

Article

Subjects

Animals; Cell Cycle Proteins; GTP-Binding Proteins; Phospholipase D; *Signal Transduction; cdc42 GTP-Binding Protein, Saccharomyces cerevisiae; rac GTP-Binding Proteins; rap GTP-Binding Proteins; ras Proteins

Abstract

It is becoming clear that Ras proteins mediate their diverse biological functions by binding to, and participating in, the activation of multiple downstream targets. Recent work has identified nucleotide-exchange factors for Ral-GTPases as the newest members of the set of putative Ras 'effector molecules'. This new work has also detected two potential downstream targets of Ral proteins, a novel CDC42/Rac GTPase-activating protein and a phospholipase D.

Rights and Permissions

Citation: Trends Biochem Sci. 1996 Nov;21(11):438-41.

Related Resources

Link to Article in PubMed

PubMed ID

8987400