Evidence for a Ras/Ral signaling cascade
Department of Cancer Biology
Animals; Cell Cycle Proteins; GTP-Binding Proteins; Phospholipase D; *Signal Transduction; cdc42 GTP-Binding Protein, Saccharomyces cerevisiae; rac GTP-Binding Proteins; rap GTP-Binding Proteins; ras Proteins
It is becoming clear that Ras proteins mediate their diverse biological functions by binding to, and participating in, the activation of multiple downstream targets. Recent work has identified nucleotide-exchange factors for Ral-GTPases as the newest members of the set of putative Ras 'effector molecules'. This new work has also detected two potential downstream targets of Ral proteins, a novel CDC42/Rac GTPase-activating protein and a phospholipase D.
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Citation: Trends Biochem Sci. 1996 Nov;21(11):438-41.