IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer
Authors
Lu, DiYang, Xiaofang
Jiang, Naomi Y.
Woda, Bruce A.
Liu, Qin
Dresser, Karen A.
Mercurio, Arthur M.
Rock, Kenneth L.
Jiang, Zhong
UMass Chan Affiliations
Department of PathologyDepartment of Medicine, Division of Preventive and Behavioral Medicine
Department of Cancer Biology
Document Type
Journal ArticlePublication Date
2011-11-01Keywords
AdultCarcinoma, Squamous Cell
Cell Movement
Cell Proliferation
Cervical Intraepithelial Neoplasia
Disease Progression
Disease-Free Survival
Female
HeLa Cells
Humans
Kaplan-Meier Estimate
Massachusetts
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Prognosis
RNA Interference
RNA-Binding Proteins
Time Factors
Tumor Markers, Biological
Uterine Cervical Neoplasms
Young Adult
Cancer Biology
Neoplasms
Pathology
Metadata
Show full item recordAbstract
The expression of IMP3, an oncofetal protein, has been strongly associated with aggressive cancers. In this study, we investigated whether IMP3 can serve as a biomarker to predict invasive squamous cell carcinoma (SCC) in patients with cervical intraepithelial neoplasia (CIN) II and III. A total of 1249 patients with no dysplasia, CINs, or invasive SCC were studied for IMP3 expression. The 710 patients with CIN II and III in their cervical biopsies were further evaluated for invasive cancer-free survival analysis. The role of IMP3 in the regulation of cell proliferation and migration of HeLa cervical cancer cells was examined by modification of IMP3 expression with small interference RNA. Compared with CIN I or cervical tissues without dysplasia, IMP3 expression was significantly increased not only in invasive SCC but also most importantly in a subset of CIN III cases with concurrent invasive SCC. Importantly, invasive cancer was found only in patients with IMP3-positive CIN II and III, whereas no invasive cancer was detected in patients with IMP3-negative CIN II and III in their follow-up resections (PSource
Am J Surg Pathol. 2011 Nov;35(11):1638-45. Link to article on publisher's site
DOI
10.1097/PAS.0b013e31823272d4Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26297PubMed ID
21997684Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1097/PAS.0b013e31823272d4