Title

Enhancing integrin function by VEGF/neuropilin signaling: Implications for tumor biology

UMMS Affiliation

Department of Cancer Biology

Date

11-2012

Document Type

Article

Subjects

Neuropilin-2; Vascular Endothelial Growth Factor A; Integrins

Abstract

This review advances the hypothesis that the ability of integrins to engage their extracellular matrix ligands and signal can be regulated in tumor cells by vascular endothelial growth factor (VEGF), a major angiogenic factor that also has direct effects on the function of tumor cells. More specifically, we will discuss how neuropilins (NRPs), a distinct class of VEGF receptors, enable the function of specific integrins that contribute to tumor initiation and progression.

Comments

Citation: Cell Adh Migr. 2012 Oct 17;6(6). Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

23076131