Enhancing integrin function by VEGF/neuropilin signaling: Implications for tumor biology
UMass Chan Affiliations
Department of Cancer BiologyDocument Type
Journal ArticlePublication Date
2012-11-01
Metadata
Show full item recordAbstract
This review advances the hypothesis that the ability of integrins to engage their extracellular matrix ligands and signal can be regulated in tumor cells by vascular endothelial growth factor (VEGF), a major angiogenic factor that also has direct effects on the function of tumor cells. More specifically, we will discuss how neuropilins (NRPs), a distinct class of VEGF receptors, enable the function of specific integrins that contribute to tumor initiation and progression.Source
Cell Adh Migr. 2012 Oct 17;6(6). Link to article on publisher's site
DOI
10.4161/cam.22419Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26292PubMed ID
23076131Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.4161/cam.22419