Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way
Department of Cancer Biology
Animals; Carcinoma; *Genes, ras; Humans; I-kappa B Kinase; Integrin alpha6beta4; Laminin; Ligands; Models, Biological; NF-kappa B; Neoplasm Invasiveness; Neoplasms, Squamous Cell; Protein-Serine-Threonine Kinases; Signal Transduction; Skin Neoplasms; ras Proteins
Although the genesis of invasive squamous cell carcinoma (SCC) from stratified epithelia of the skin is considered to be a complex, multistage process, recent work on human epidermis reveals that sustained Ras signaling coupled with suppression of Ras-induced growth arrest is sufficient to drive the entire process and that the alpha6beta4 integrin and its laminin 5 ligand are essential components of this process.
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Citation: Cancer Cell. 2003 Mar;3(3):201-2.
Mercurio, Arthur M., "Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way" (2003). Cancer Biology Publications and Presentations. Paper 163.