Editors: Richard S. Pieters, MD and James Liebmann, MD
Associate Editor: Maryann Bishop-Jodoin, MEd
Assistant Editors: Jean Boucher, PhD, RN, NP; Andrew Chen, MD; Ediz Cosar, MD; Lisa A. Palmer, MSLS; Patricia Webster, MS, RT(T)
Established by the Department of Radiation Oncology and the Department of Medicine, Division of Hematology Oncology at the University of Massachusetts Medical School
Cancer Concepts Table of Contents:
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- Biological Basis of Oncology & Principles of Multidisciplinary Therapy
- Epidemiology and the Cancer Problem
- Environmental and Infectious Causes of Malignancy
- Familial Cancer Syndromes
- Nutrition and Cancer
- Cancer Biology
- Oncologic Imaging
- Staging of Cancer
- Oncologic Emergencies and Urgencies
- Principles of Multidisciplinary Management
- Principles of Radiation Oncology
- Principles of Medical Oncology
- Cancer Treatment Drugs
- Pediatric Oncology Principles
Image credit: The Cancer Concepts logo is adapted from DNA replication split by Madeline Price Ball published under a CC0 license.
Funding Statement: This project has been funded in whole or in part with federal funds from the National Library of Medicine, National Institutes of Health, under Contract No. HHSN276201100010C with the University of Massachusetts, Worcester.
Beverly N. Hay
While the majority of cancers are not inherited, there are a number of well described collections of cancers that occur within families. These cancer syndromes were initially identified based on observation of the family history and subsequently the molecular mechanisms have been elucidated. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist is intended to allow the reader to recognize when a pattern of cancers occurs in an individual or their family, and to generate an investigation into potential cancer syndromes. With the rapidly expanding understanding of the molecular basis of cancers at the cellular and constitutional levels, appropriate preventive care may be offered and tailored treatment holds great promise.
Richard J. Horner
Over eighty different compounds have been approved to treat cancer. Their mechanisms of action, effectiveness against specific cancers, and potential toxicity vary greatly. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist will describe, in terms of mechanism of action, the most important classes of cytotoxic and targeted therapies as well as their most characteristic side effects and clinical uses. A table summarizing the classes of drugs and representative members of those classes is included at the end of the chapter. Rather than an encyclopedia, this will be a schematic diagram or roadmap to more detailed knowledge that you will acquire during your clinical training and subsequent experience.
James Liebmann and Richard S. Pieters
Medical oncologists are internists specializing in the care of the adult cancer patient. They frequently function as a primary care physician for patients with cancer. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist will review the practice of medical oncology and some general principles followed in the use of chemotherapy. Concepts including goals of chemotherapy treatment, evaluation of the effects of chemotherapy, integration of chemotherapy with other cancer treatments, and use of combinations of chemotherapy drugs will be covered.
John J. Shim and Andrew Chen
Imaging is an integral part of the multidisciplinary management of cancer. Radiographic techniques are indispensable for proper staging of cancers and evaluation of the response of tumors to treatment. A wide variety of imaging modalities is available to clinicians. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist will introduce the role of radiology in the diagnosis and treatment of cancer.
Amanpreet Buttar, Laura A. Lambert, James Liebmann, and Richard S. Pieters
Cancers of unknown primary (CUP) are a heterogeneous group of histologically proven metastatic tumors whose primary site can't be determined after a standard diagnostic and pathologic work-up. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents provides an overview of cancers of unknown primary, including initial evaluation and principles of treatment.
Maria Giulia Cicchetti, James Liebmann, Andrew Chen, Carolynn DeBenedectis, and Elizabeth Kurian
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of breast cancer, including etiology, screening, pathology, staging, and treatment.
Anne Garrison, Andrew H. Fischer, Adib R. Karam, Antonella Leary, and Richard S. Pieters
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents provides an overview of cervical cancer. The etiology, pathology, staging, and principles of treatment will be reviewed.
Jeffrey A. Gordon, Elizabeth Kurian, Arash Bedayat, Ali Akalin, Karl Uy, and Richard S. Pieters
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of lung cancer and mesothelioma, including epidemiology, etiology, screening, pathology, staging, and treatment.
Christopher P. Keuker
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of childhood cancer, including the incidence, distribution, diagnosis, treatment, and survivorship.
Mary Linton Peters, Richard S. Pieters, and James Liebmann
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents a summary of the most relevant causative agents of cancer. Exposure to many environmental agents is associated with an increased incidence of certain malignancies, although causation is usually difficult to prove. Certain chemicals, infections (parasitic, viral, and bacterial) and ionizing radiation are known carcinogens. Variable genetic susceptibility to carcinogenesis is apparent. Up to 2/3 of human cancers are believed to have an environmental component.
Richard S. Pieters and James Liebmann
This chapter in Cancer Concepts: a Guidebook for the Non-Oncologist describes the principles of multi-disciplinary management, meaning multi-specialty physician management of malignancies. Tumor Boards are the model for multi-disciplinary management. They may be site specific or include the entire spectrum of malignancy. At Tumor Boards, staging workup and treatment recommendations are made collectively, and then the treatments are delivered by the respective modality specialists and their individual teams. Improved clinical decision making leading to superior survival for patients with some diseases and better quality of life has been documented with multi-disciplinary management. Just like curative patients, palliative patients require multi-disciplinary management.
Richard S. Pieters, Joyce Rosenfeld, Andrew Chen, and James Liebmann
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents a discussion of the risks to cancer patients for oncologic and metabolic crises. These effects may be caused by the cancer, the treatment provided to cure or palliate the cancer, and/or other medical conditions. They may occur at initial presentation, as a first sign of disease or during the disease course. Oncologists divide these crises into emergencies and urgencies, depending on the severity of the consequences of delay in treatment. Every health care provider should be aware of the signs and symptoms of oncologic urgencies and emergencies and initial management.
Paul R. Sturrock, James Liebmann, Adib R. Karam, Richard S. Pieters, and Elizabeth Kurian
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of colorectal cancer, including etiology, screening, pathology, staging, and treatment.
Bruce A. Woda, James Liebmann, and Elizabeth Kurian
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist focuses on DNA mutations that cause cancer, abnormal regulation of cell growth and death, and metastasis.
Epidemiology is the study of populations using defined research methods to confirm the patterns and causes of disease and applying this information to improve the health of the populations. This branch of science is the basis for understanding the spread of diseases in a defined area or group of people. Epidemiologic studies have been instrumental in improving outcomes by establishing preventive and therapeutic measures for the incidence, prevalence and mortality from cancers. The incidence of malignancy in a country or in our world defines the magnitude of the cancer problem. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist will introduce the role of epidemiology in the diagnosis and treatment of cancer.
Angela Beeler, Katherine Saunders, Alexis Penney, James Liebmann, and Richard S. Pieters
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents a summary of the nutritional concerns in oncology patients. Nutritional intake is frequently deficient in patients undergoing cancer treatment and should be assessed and treated. There are unique nutritional needs of the patient based on their site of cancer and effects of their particular treatment. There is little evidence that dietary manipulation or supplementation can produce a significant decrease in cancer risk.
Richard S. Pieters, Maryann Bishop-Jodoin, and James Liebmann
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an introduction to the Guidebook, which developed from the Cancer Concepts course at the University of Massachusetts Medical School.
Richard S. Pieters, Maryanne Bombaugh, Yuxin Liu, Gina Cunto-Amesty, Adib R. Karam, Elizabeth Kurian, and Sarah Huges
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist is about cancers of the endometrium and uterus, including the epidemiology, risk factors, diagnosis, genetic risk, histology, grading and type categorization, management, and prognosis.
Richard S. Pieters, Linda Ding, Harry Bushe, and Jesse N. Aronowitz
This chapter in Cancer Concepts: a Guidebook for the Non-Oncologist describes the principles of Radiation Oncology. Radiation Oncology utilizes ionizing radiation to treat cancer (and occasionally a few benign conditions). Radiotherapy or radiation therapy (RT) was initially developed in conjunction with diagnostic radiology, but has evolved into a separate specialty. Currently, more than fifty percent of cancer patients undergo RT at some point during the course of their cancer. Most receive treatment with curative intent (radical therapy); however, patients with incurable disease receive shorter, gentler courses of therapy to relieve cancer-induced symptoms.
Mary Linton Peters, Richard S. Pieters, James Liebmann, and Geoffrey Graeber
The “stage” of a cancer is a short-hand way of describing the extent of cancer in a patient. Stage is based on macroscopic involvement of tissues by cancer. Staging of cancer occurs prior to the beginning of treatment, or at the first definitive surgery. Clinical staging, which includes radiography and exam findings, takes place initially. Pathologic staging, which is obtained from surgical specimens, can be acquired during the course of surgical treatment. Patients then carry either the clinical stage or the pathologic stage for the duration of their illness. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist will describe principles of cancer staging.