Publications from 2007
The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing, Angela Miele, Ricardo F. Medina, Andre J. Van Wijnen, Gary S. Stein, and Janet L. Stein
N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure, Yumi Mitsuya, Mark A. Winters, W. Jeffrey Fessel, Soo-Yon Rhee, Leo Hurley, Michael Horberg, Celia A. Schiffer, Andrew R. Zolopa, and Robert W. Shafer
Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence, Martin A. Montecino, Janet L. Stein, Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Fernando Cruzat, Soraya E. Gutierrez, Juan Olate, Sylvain Marcellini, and Jose L. Gutierrez
A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes, Trevor J. Morin and William R. Kobertz
Dam methyltransferase is required for stable lysogeny of the Shiga toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7, Kenan C. Murphy, Jennifer M. Ritchie, Matthew K. Waldor, Anders Lobner-Olesen, and Martin G. Marinus
Crystal structure of lysine sulfonamide inhibitor reveals the displacement of the conserved flap water molecule in human immunodeficiency virus type 1 protease, Madhavi N. L. Nalam, Anik Peeters, Tim H. M. Jonckers, Inge Dierynck, and Celia A. Schiffer
DNA mismatch repair-induced double-strand breaks, Anetta Nowosielska and Martin G. Marinus
Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5, John M. Pagano Jr., Brian M. Farley, Lisa M. McCoig, and Sean P. Ryder
The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor, Seema Paliwal, Ramesh C. Kovi, Bharath D. Nath, Ya-Wen Chen, Brian C. Lewis, and Steven R. Grossman
Development of Ad-mda7/IL-24-resistant lung cancer cell lines, Abujiang Pataer, Sunil Chada, Jack A. Roth, Kelly K. Hunt, and Stephen G. Swisher
Progress, paradox, and potential: parathyroid hormone research over five decades, John T. Potts and Thomas James Gardella
Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres, G. S. Kiran Kumar Reddy, Akbar Ali, Madhavi N. L. Nalam, Saima G. Anjum, Hong Cao, Robin S. Nathans, Celia A. Schiffer, and Tariq M. Rana
Effects of vpu start-codon mutations on human immunodeficiency virus type 1 replication in macrophages, Kathryn H. Richards and Paul R. Clapham
Nitrite does not provide additional protection to thrombolysis in a rat model of stroke with delayed reperfusion, Bawarjan Schatlo, Erica C. Henning, Ryszard M. Pluta, Lawrence L. Latour, Nahal Golpayegani, Marsha J. Merrill, Naomi Lewin, Yong Chen, and Edward H. Oldfield
Zebrafish ae2.2 encodes a second slc4a2 anion exchanger, Boris E. Shmukler, Jeffrey S. Clark, Ann Hsu, David H. Vandorpe, Andrew K. Stewart, Christine E. Kurschat, Seong-Kyu Choe, Yi Zhou, Julio D. Amigo, Barry H. Paw, and Seth L. Alper
Measuring the rates of transcriptional elongation in the female Drosophila melanogaster germ line by nuclear run-on, Alla A. Sigova, Vasily V. Vagin, and Phillip D. Zamore
Supply and Demand in Cerebral Energy Metabolism: the Role of Nutrient Transporters, Ian A. Simpson, Anthony Carruthers, and Susan J. Vannucci
Distinct Roles for Two G{alpha} G Interfaces in Cell Polarity Control by a Yeast Heterotrimeric G Protein, Shelly Catherine Strickfaden and Peter M. Pryciak
grp (chk1) replication-checkpoint mutations and DNA damage trigger a Chk2-dependent block at the Drosophila midblastula transition, Saeko Takada, Seongae Kwak, Birgit S. Koppetsch, and William E. Theurkauf
Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance, Thomas B. Thornley, Nancy E. Phillips, Britte C. Beaudette-Zlatanova, Thomas G. Markees, Kapil Bahl, Michael A. Brehm, Leonard D. Shultz, Evelyn A. Kurt-Jones, John P. Mordes, Raymond M. Welsh, Aldo A. Rossini, and Dale L. Greiner
Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells, Prasanna Venkatraman, Tina T. Nguyen, Matthieu Sainlos, Osman Bilsel, Sriram Chitta, Barbara Imperiali, and Lawrence J. Stern
TRAIL is a novel antiviral protein against dengue virus, Rajas V. Warke, Katherine J. Martin, Krisanthi Giaya, Sunil K. Shaw, Alan L. Rothman, and Irene Bosch
A tightly packed hydrophobic cluster directs the formation of an off-pathway sub-millisecond folding intermediate in the alpha subunit of tryptophan synthase, a TIM barrel protein, Ying Wu, Ramakrishna Vadrevu, Sagar V. Kathuria, Xiaoyan Yang, and C. Robert Matthews
Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement, Xiaofang Yang, Roser Zaurin, Miguel Beato, and Craig L. Peterson
Long-range side-chain-main-chain interactions play crucial roles in stabilizing the (betaalpha)8 barrel motif of the alpha subunit of tryptophan synthase, Xiaoyan Yang, Ramakrishna Vadrevu, Ying Wu, and C. Robert Matthews
Dissociation of halted T7 RNA polymerase elongation complexes proceeds via a forward-translocation mechanism, Yi Zhou, Deanna M. Navaroli, Metewo Selase Enuameh, and Craig T. Martin
Publications from 2006
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands, Akbar Ali, G. S. Kiran Kumar Reddy, Hong Cao, Saima G. Anjum, Madhavi N. L. Nalam, Celia A. Schiffer, and Tariq M. Rana
The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells, Luana O. Atherly, Julie Ann Lucas, Martin Felices, Catherine C. Yin, Steven L. Reiner, and Leslie J. Berg
Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation, Jong-Sup Bae, Soraya E. Gutierrez, Radhika Narla, Jitesh Pratap, Rajitha Devados, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Jane B. Lian, and Amjad Javed
IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections, Kapil Bahl, Sung-Kwon Kim, Claudia Calcagno, Dario Ghersi, Roberto Puzone, Franco Celada, Liisa K. Selin, and Raymond M. Welsh
Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase, Klaus A. Becker, Prachi N. Ghule, Jaclyn A. Therrien, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein
Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells, Klaus A. Becker, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein
H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy, Jorg Bewersdorf, Brian Thomas Bennett, and Kendall L. Knight
The classic receptor for 1alpha,25-dihydroxy vitamin D3 is required for non-genomic actions of 1alpha,25-dihydroxy vitamin D3 in osteosarcoma cells, Soraya Bravo, Roberto Paredes, Pamela Izaurieta, Jane B. Lian, Janet L. Stein, Gary S. Stein, Maria Victoria Hinrichs, Juan Olate, Luis G. Aguayo, and Martin A. Montecino
Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length, Kenneth Geno Campellone, Michael John Brady, Judith G. Alamares, Daniel C. Rowe, Brian M. Skehan, Donald J. Tipper, and John M. Leong
KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression, Kshama D. Chandrasekhar, Tuba Bas, and William R. Kobertz
S. pombe FEAR protein orthologs are not required for release of Clp1/Flp1 phosphatase from the nucleolus during mitosis, Chun-Ti Chen, Marie-Pierre Peli-Gulli, Viesturs Simanis, and Dannel McCollum
Slow translocon gating causes cytosolic exposure of transmembrane and lumenal domains during membrane protein integration, Zhiliang Cheng and Reid Gilmore
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity, Markus Cornberg, Alex T. Chen, Lee A. Wilkinson, Michael A. Brehm, Sung-Kwon Kim, Claudia Calcagno, Dario Ghersi, Roberto Puzone, Franco Celada, Raymond M. Welsh, and Liisa K. Selin
Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism, Mu-Shui Dai, Dingding Shi, Yetao Jin, Xiao-Xin Sun, Yanping Zhang, Steven R. Grossman, and Hua Lu
Noble metals strip peptides from class II MHC proteins, Stephen J. De Wall, Corrie A. Painter, Jennifer D. Stone, Rajintha M. Bandaranayake, Don C. Wiley, Timothy J. Mitchison, Lawrence J. Stern, and Brian S. DeDecker
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways, Thomas F. Duchaine, James A. Wohlschlegel, Scott Kennedy, Yanxia Bei, Darryl Conte, Ka Ming Pang, Daniel R. Brownell, Sandra Harding, Shohei Mitani, Gary Ruvkun, John R. Yates, and Craig C. Mello
Non-enzymatic interactions of glyoxylate with lysine, arginine, and glucosamine: a study of advanced non-enzymatic glycation like compounds, Udayan Dutta, Menashi A. Cohenford, Madhumita Guha, and Joel A. Dain
RecA dimers serve as a functional unit for assembly of active nucleoprotein filaments, Anthony L. Forget, Michelle M. Kudron, Dharia A. McGrew, Melissa A. Calmann, Celia A. Schiffer, and Kendall L. Knight
Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity, Jennifer E. Foulkes-Murzycki, Moses Prabu-Jeyabalan, Deyna Cooper, Gavin J. Henderson, Janera Harris, Ronald I. Swanstrom, and Celia A. Schiffer
E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts, Fiona M. Frame, Harry A. Rogoff, Mary Theresa Pickering, W. Douglas Cress, and Timothy F. Kowalik
Asymmetric ERM activation at the Schwann cell process tip is required in axon-associated motility, Cheryl L. Gatto, Barbara J. Walker, and Stephen Lambert
Asymmetric ERM activation at the Schwann cell process tip is required in axon-associated motility, Cheryl Lynn Gatto, Barbara J. Walker, and Stephen Lambert
Ultrastructure of human erythrocyte GLUT1, Christopher A. Graybill, Alfred N. van Hoek, D. Desai, Andrew M. Carruthers, and Anthony Carruthers
BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network, Mohammad Q. Hassan, Rahul S. Tare, Suk Hee Lee, Matthew Mandeville, Maria I. Morasso, Amjad Javed, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis, Akira Hayakawa, Deborah Marie Leonard, Stephanie Murphy, Susan J. Hayes, Martha C. Soto, Kevin E. Fogarty, Clive Standley, Karl D. Bellve, David G. Lambright, Craig C. Mello, and Silvia Corvera
Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling, Richard D. Hayward, John M. Leong, Vassilis Koronakis, and Kenneth Geno Campellone
CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA, Yi-Shuian Huang, Ming-Chung Kan, Chien-Ling Lin, and Joel D. Richter
Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein, Surbhi Jain, Lori McGinnes, and Trudy G. Morrison
Dynamics and magnitude of virus-induced polyclonal B cell activation mediated by BCR-independent presentation of viral antigen, Evan Robert Jellison, Heath M. Guay, Eva Szomolanyi-Tsuda, and Raymond M. Welsh
Co-evolution of nelfinavir-resistant HIV-1 protease and the p1-p6 substrate, Madhavi Kolli, Stephane Lastere, and Celia A. Schiffer
Cdc2 tyrosine phosphorylation is not required for the S-phase DNA damage checkpoint in fission yeast, Naveen Kommajosyula and Nicholas R. Rhind
Itk and Th2 responses: action but no reaction, Yoko Kosaka, Martin Felices, and Leslie J. Berg
Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia, Ya-Huei Kuo, Sean F. Landrette, Susan Ann Heilman, Paola N. Perrat, Lisa Garrett, Pu P. Liu, Michelle M. Le Beau, Scott C. Kogan, and Lucio H. Castilla
Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2, Xiaozhen Liang, Mary Theresa Pickering, Nam-Hyuk Cho, Heesoon Chang, Michael R. Volkert, Timothy F. Kowalik, and Jae U. Jung
The beta sliding clamp binds to multiple sites within MutL and MutS, Francisco J. Lopez de Saro, Martin G. Marinus, Paul Modrich, and Mike O'Donnell
Homologous recombination prevents methylation-induced toxicity in Escherichia coli, Anetta Nowosielska, Stephen A. Smith, Bevin P. Engelward, and Martin G. Marinus
Substrate specificity in HIV-1 protease by a biased sequence search method, Nevra Ozer, Turkan Haliloglu, and Celia A. Schiffer
Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease, Moses Prabu-Jeyabalan, Nancy M. King, Ellen A. Nalivaika, Gabrielle Heilek-Snyder, Nick Cammack, and Celia A. Schiffer
Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate, Moses Prabu-Jeyabalan, Ellen A. Nalivaika, Keith Romano, and Celia A. Schiffer
Hda-mediated inactivation of the DnaA protein and dnaA gene autoregulation act in concert to ensure homeostatic maintenance of the Escherichia coli chromosome, Leise Riber, Jan A. Olsson, Rasmus B. Jensen, Ole Skovgaard, Santanu Dasgupta, Martin G. Marinus, and Anders Lobner-Olesen
Introduction on the use of the Drosophila embryonic/larval neuromuscular junction as a model system to study synapse development and function, and a brief summary of pathfinding and target recognition, Catalina Ruiz-Canada and Vivian Budnik
Synaptic cytoskeleton at the neuromuscular junction, Catalina Ruiz-Canada and Vivian Budnik
S-nitrosothiol depletion in amyotrophic lateral sclerosis, Christopher M. Schonhoff, Masaaki Matsuoka, Hemachand Tummala, Michael A. Johnson, Alvaro G. Estevez, Rui Wu, Andres Kamaid, Karina C. Ricart, Yuichi Hashimoto, Benjamin M. Gaston, Timothy L. Macdonald, Zuoshang Xu, and Joan B. Mannick
Designing siRNA that distinguish between genes that differ by a single nucleotide, Dianne S. Schwarz, Hongliu Ding, Lori A. Kennington, Jessica T. Moore, Janell M. Schelter, Julja Burchard, Peter S. Linsley, Neil Aronin, Zuoshang Xu, and Phillip D. Zamore
A distinct small RNA pathway silences selfish genetic elements in the germline, Vasily V. Vagin, Alla A. Sigova, Chengjian Li, Herve Seitz, Vladimir Gvozdev, and Phillip D. Zamore
Publications from 2005
Monoclonal antibody routinely used to identify avirulent strains of Newcastle disease virus binds to an epitope at the carboxy terminus of the hemagglutinin-neuraminidase protein and recognizes individual mesogenic and velogenic strains, Judith G. Alamares, Jianrong Li, and Ronald M. Iorio
Aberrant termination triggers nonsense-mediated mRNA decay, Nadia Amrani, Shuyun Dong, Feng He, Robin Ganesan, Shubhendu Ghosh, Stephanie Kervestin, Chunfang Li, David A. Mangus, Phyllis Spatrick, and Allan Jacobson
Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51, Brian Thomas Bennett and Kendall L. Knight
Tec family kinases in T lymphocyte development and function, Leslie J. Berg, Lisa D. Finkelstein, Julie Ann Lucas, and Pamela L. Schwartzberg
Biaxial failure properties of planar living tissue equivalents, Kristen L. Billiar, Angela M. Throm, and Margo Tilley Frey
Quench-flow analysis reveals multiple phases of GluT1-mediated sugar transport, David M. Blodgett and Anthony Carruthers
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades, Deborah Marie Brancho, Juan-Jose Ventura, Anja Jaeschke, Beth Doran, Richard A. Flavell, and Roger J. Davis
Target accessibility dictates the potency of human RISC, Kirk M. Brown, Chia-ying Chu, and Tariq M. Rana
MutS inhibits RecA-mediated strand transfer with methylated DNA substrates, Melissa A. Calmann, James E. Evans, and Martin G. Marinus
Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli, Melissa A. Calmann and Martin G. Marinus
Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant, Melissa A. Calmann, Anetta Nowosielska, and Martin G. Marinus
The MutS C terminus is essential for mismatch repair activity in vivo, Melissa A. Calmann, Anetta Nowosielska, and Martin G. Marinus
Nck-independent actin assembly is mediated by two phosphorylated tyrosines within enteropathogenic Escherichia coli Tir, Kenneth Geno Campellone and John M. Leong
Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation, Quiping Cao, Yi-Shuian Huang, Ming-Chung Kan, and Joel D. Richter
Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response, Jonathan Patrick Castillo, Fiona M. Frame, Harry A. Rogoff, Mary T. Pickering, Andrew D. Yurochko, and Timothy F. Kowalik
A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans, Chun-Chieh G. Chen, Martin J. Simard, Hiroaki Tabara, Daniel R. Brownell, Jennifer A. McCollough, and Craig C. Mello
Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation, Zhiliang Cheng, Ying Jiang, Elisabet C. Mandon, and Reid Gilmore
Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae, Wang L. Cheung, Fiona B. Turner, Thanuja Krishnamoorthy, Branden Wolner, Sung-Hee Ahn, Melissa Anne Foley, Jean A. Dorsey, Craig L. Peterson, Shelley L. Berger, and C. David Allis
Dissecting RNA-interference pathway with small molecules, Ya-Lin Chiu, Chimmanamada U. Dinesh, Chia-ying Chu, Akbar Ali, Kirk M. Brown, Hong Cao, and Tariq M. Rana
Centrosome control of the cell cycle, Stephen J. Doxsey, Wendy Cherie Zimmerman, and Keith Mikule
microPrimer: the biogenesis and function of microRNA, Tingting Du and Phillip D. Zamore
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells, Sonya G. Fonseca, Mariko Fukuma, Kathryn L. Lipson, Linh X. Nguyen, Jenny R. Allen, Yoshitomo Oka, and Fumihiko Urano
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein, Klaus Forstemann, Yukihide Tomari, Tingting Du, Vasily V. Vagin, Ahmet M. Denli, Diana P. Bratu, Carla Andrea Klattenhoff, William E. Theurkauf, and Phillip D. Zamore
The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts, Mario Galindo, Jitesh Pratap, Daniel W. Young, Hayk Hovhannisyan, Hee-Jeong Im, Je-Yong Choi, Jane B. Lian, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen
Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans, Melissa M. Grabowski, Nenad Svrzikapa, and Heidi A. Tissenbaum
Coordinate control and selective expression of the full complement of replication-dependent histone H4 genes in normal and cancer cells, William F. Holmes, Corey D. Braastad, Partha Mitra, Cornelia Hampe, Detlef Doenecke, Werner Albig, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein
Myosin X is a high duty ratio motor, Kazuaki Homma and Mitsuo Ikebe
Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1, Stefan Huttelmaier, Daniel Zenklusen, Marcell Lederer, Jason B. Dictenberg, Mike Lorenz, Xiuhua Meng, Gary J. Bassell, John S. Condeelis, and Robert H. Singer
Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo, Amjad Javed, George L. Barnes, Jitesh Pratap, Tomasz Antkowiak, Louis C. Gerstenfeld, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, and Gary S. Stein