This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Biochemistry and Molecular Pharmacology.

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Publications from 2012

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First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G, Ming Li, Shivender Shandilya, Michael A. Carpenter, Anurag Rathore, William L. Brown, Angela L. Perkins, Daniel A. Harki, Jonathan Solberg, Derek J. Hook, Krishan K. Pandey, Michael A. Parniak, Jeffrey R. Johnson, Nevan J. Krogan, Mohan Somasundaran, Akbar Ali, Celia A. Schiffer, and Reuben S. Harris

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Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease, Seema Mittal, Yufeng Cai, Madhavi N. L. Nalam, Daniel N. A. Bolon, and Celia A. Schiffer

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Angiogenic biomarkers for prediction of maternal and neonatal complications in suspected preeclampsia., Andreea G. Moore, Heather Young, Jennifer M. Keller, Linda R. Ojo, Jing Yan, Tiffany A. Moore Simas, and Sharon E. Maynard

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Mid-gestation Angiogenic Biomarker Levels are Increased in Women at High Risk for Preeclampsia, Tiffany A. Moore Simas, Sybil L. Crawford, Susie Bathgate, Jing Yang, Laura Robidoux, Melissa J. Moore, and Sharon E. Maynard

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Structural insights into neuronal K+ channel-calmodulin complexes, Karen Mruk, Shivender Shandilya, Robert O. Blaustein, Celia A. Schiffer, and William R. Kobertz

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Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles, Christian Mueller, Qiushi Tang, Alisha Gruntman, Keith S. Blomenkamp, Jeffrey H. Teckman, Lina Song, Phillip D. Zamore, and Terence R. Flotte

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Quantitative comparison of errors in 15N transverse relaxation rates measured using various CPMG phasing schemes, Wazo Myint, Yufeng Cai, Celia A. Schiffer, and Rieko Ishima

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Human CD4+ T cell response to human herpesvirus 6, Maria-Dorothea Nastke, Aniuska Becerra, Liusong Yin, Omar Dominguez-Amorocho, Laura L. Gibson, Lawrence J. Stern, and J. Mauricio Calvo-Calle

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Analysis of long-range chromatin interactions using Chromosome Conformation Capture, Natalia Naumova, Emily M. Smith, Ye Zhan, and Job Dekker

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Serine/threonine acetylation of TGFbeta-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling, Nicholas Paul Paquette, Joseph E. Conlon, Charles R. Sweet, Florentina Rus, Lindsay Wilson, Andrea J. Pereira, Charles V. Rosadini, Nadege Goutagny, Alexander N. R. Weber, William S. Lane, Scott A. Shaffer, Stephanie Maniatis, Katherine A. Fitzgerald, Lynda M. Stuart, and Neal S. Silverman

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Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance, Maloy Kumar Parai, David J. Huggins, Hong Cao, Madhavi N. L. Nalam, Akbar Ali, Celia A. Schiffer, Bruce Tidor, and Tariq M. Rana

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A key role for chd1 in histone h3 dynamics at the 3' ends of long genes in yeast, Marta Radman-Livaja, Tiffani K. Quan, Lourdes Valenzuela, Jennifer A. Armstrong, Tibor van Welsem, Tae Soo Kim, Laura J. Lee, Stephen Buratowski, Fred van Leeuwen, Oliver J. Rando, and Grant A. Hartzog

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Immune responses in cystic fibrosis: are they intrinsically defective?, Dmitry Ratner and Christian Mueller

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The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors, Keith P. Romano, Akbar Ali, Cihan Aydin, Djade Soumana, Aysegul Ozen, Laura M. Deveau, Casey Silver, Hong Cao, Alicia Newton, Christos J. Petropoulos, Wei Huang, and Celia A. Schiffer

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The long-range interaction landscape of gene promoters, Amartya Sanyal, Bryan R. Lajoie, Gaurav Jain, and Job Dekker

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Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons, Hennady P. Shulha, Iris Cheung, Catheryne Whittle, Jie Wang, Daniel Virgil, Cong L. Lin, Yin Guo, Andree Lessard, Schahram Akbarian, and Zhiping Weng

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The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus, Guramrit Singh, Alper Kucukural, Can Cenik, John D. Leszyk, Scott A. Shaffer, Zhiping Weng, and Melissa J. Moore

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Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling, Sean D. Speese, James A. Ashley, Vahbiz Jokhi, John J. Nunnari, Romina Barria, Yihang Li, Bulent Ataman, Alex C. Koon, Young-Tae Chang, Qian Li, Melissa J. Moore, and Vivian Budnik

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Sequence Determinants of GLUT1-mediated Accelerated-exchange Transport: Analysis by Homology-Scanning Mutagenesis, Sabrina S. Vollers and Anthony Carruthers

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Prediction of protein-protein binding free energies, Thom Vreven, Howook Hwang, Brian G. Pierce, and Zhiping Weng

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Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors, Jie Wang, Jiali Zhuang, Sowmya Iyer, Xinying Lin, Troy W. Whitfield, Melissa C. Greven, Brian G. Pierce, Xianjun Dong, Anshul Kundaje, Yong Cheng, Oliver J. Rando, Ewan Birney, Richard M. Myers, William S. Noble, Michael Snyder, and Zhiping Weng

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Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties, LiangMeng Wee, Carlos Fabian Flores-Jasso, William E. Salomon, and Phillip D. Zamore

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Functional analysis of transcription factor binding sites in human promoters, Troy W. Whitfield, Jie Wang, Patrick J. Collins, E. Christopher Partridge, Shelley Force Aldred, Nathan D. Trinklein, Richard M. Myers, and Zhiping Weng

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Long-term, efficient inhibition of microRNA function in mice using rAAV vectors, Jun Xie, Stefan L. Ameres, Randall H. Friedline, Jui-Hung Hung, Yu Zhang, Qing Xie, Li Zhong, Qin Su, Ran He, Mengxin Li, Huapeng Li, Xin Mu, Hongwei Zhang, Jennifer A. Broderick, Jason K. Kim, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

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Modeling formamide denaturation of probe-target hybrids for improved microarray probe design in microbial diagnostics, L. Safak Yilmaz, Alexander Loy, Erik S. Wright, Michael Wagner, and Daniel R. Noguera

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UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery, Fan Zhang, Jie Wang, Jia Xu, Zhao Zhang, Birgit S. Koppetsch, Nadine Schultz, Thom Vreven, Carine Meignin, Ilan Davis, Phillip D. Zamore, Zhiping Weng, and William E. Theurkauf

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Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection, Zhao Zhang, William E. Theurkauf, Zhiping Weng, and Phillip D. Zamore

Publications from 2011

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Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins, Stefan L. Ameres, Jui-Hung Hung, Jia Xu, Zhiping Weng, and Phillip D. Zamore

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The challenge of developing robust drugs to overcome resistance, Amy C. Anderson, Michael P. Pollastri, Celia A. Schiffer, and Norton P. Peet

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The three-dimensional folding of the α-globin gene domain reveals formation of chromatin globules, Davide Bau, Amartya Sanyal, Bryan R. Lajoie, Emidio Capriotti, Meg Byron, Jeanne B. Lawrence, Job Dekker, and Marc A. Marti-Renom

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Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence, Eugene Berezikov, Nicolas Robine, Anastasia Samsonova, Jakub Orzechowski Westholm, Ammar Naqvi, Jui-Hung Hung, Katsutomo Okamura, Qi Dai, Diane Bortolamiol-Becet, Raquel Martin, Yongjun Zhao, Phillip D. Zamore, Gregory J. Hannon, Marco A. Marra, Zhiping Weng, Norbert Perrimon, and Eric C. Lai

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Molecular basis of a million-fold affinity maturation process in a protein-protein interaction, Daniel A. Bonsor, Sandra Postel, Brian G. Pierce, Ningyan Wang, Penny Zhu, Rebecca A. Buonpane, Zhiping Weng, David M. Kranz, and Eric J. Sundberg

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Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing, Jennifer A. Broderick, William E. Salomon, Sean P. Ryder, Neil Aronin, and Phillip D. Zamore

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MicroRNA therapeutics, Jennifer A. Broderick and Phillip D. Zamore

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Phosphate and R2D2 Restrict the Substrate Specificity of Dicer-2, an ATP-Driven Ribonuclease, Elif Sarinay Cenik, Ryuya Fukunaga, Gang Lu, Robert Dutcher, Yeming Wang, Traci M. Tanaka Hall, and Phillip D. Zamore

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Argonaute proteins, Elif Sarinay Cenik and Phillip D. Zamore

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A modified bacterial one-hybrid system yields improved quantitative models of transcription factor specificity, Ryan G. Christensen, Ankit Gupta, Zheng Zuo, Lawrence A. Schriefer, Scot A. Wolfe, and Gary D. Stormo

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TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors, Inge Dierynck, Herwig Van Marck, Marcia Van Ginderen, Tim H. M. Jonckers, Madhavi N. L. Nalam, Celia A. Schiffer, Araz Raoof, Guenter Kraus, and Gaston Picchio

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Community-wide assessment of protein-interface modeling suggests improvements to design methodology, Sarel J. Fleishman, Howook Hwang, Thom Vreven, Brian G. Pierce, and Zhiping Weng

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Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases, Ankit Gupta, Xiangdong Meng, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1, Bo W. Han, Jui-Hung Hung, Zhiping Weng, Phillip D. Zamore, and Stefan L. Ameres

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Experimental illumination of a fitness landscape, Ryan T. Hietpas, Jeffrey D. Jensen, and Daniel N. A. Bolon

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A machine learning approach for the prediction of protein surface loop flexibility, Howook Hwang, Thom Vreven, Troy W. Whitfield, Kevin Wiehe, and Zhiping Weng

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ACT: aggregation and correlation toolbox for analyses of genome tracks, Justin Jee, Joel Rozowsky, Kevin Y. Yip, Lucas Lochovsky, Robert Bjornson, Guoneng Zhong, Zhengdong Zhang, Yutao Fu, Jie Wang, Zhiping Weng, and Mark B. Gerstein

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FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans, Irene Kalchhauser, Brian M. Farley, Sandra Pauli, Sean P. Ryder, and Rafal Ciosk

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A structure-based benchmark for protein-protein binding affinity, Panagiotis L. Kastritis, Iain H. Moal, Howook Hwang, Zhiping Weng, Paul A. Bates, Alexandre M. J. J. Bonvin, and Joel Janin

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Structural insights into early folding events using continuous-flow time-resolved SAXS, Sagar V. Kathuria, Liang Guo, Rita Graceffa, Raul Barrea, R. Paul Nobrega, C. Robert Matthews, Tom Irving, and Osman Bilsel

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Adaptation to P element transposon invasion in Drosophila melanogaster, Jaspreet S. Khurana, Jie Wang, Jia Xu, Birgit S. Koppetsch, Travis Thomson, Anetta Nowosielska, Chengjian Li, Phillip D. Zamore, Zhiping Weng, and William E. Theurkauf

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Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish, Nathan D. Lawson and Scot A. Wolfe

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The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing, Luis G. Morello, Patricia P. Coltri, Alexandre J.C. Quaresma, Fernando M. Simabuco, Tereza C.L. Sila, Guramrit Singh, Jeffrey A. Nickerson, Carla C. Oliveira, Melissa J. Moore, and Nilson I. T. Zanchin

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Xenopus laevis oocytes infected with multi-drug-resistant bacteria: implications for electrical recordings, Denice O'Connell, Karen Mruk, Jessica M. Rocheleau, and William R. Kobertz

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Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope, Aysegul Ozen, Turkan Haliloglu, and Celia A. Schiffer

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Conformational lability in the class II MHC 3-10 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange, Corrie A. Painter, Maria P. Negroni, Kathy A. Kellersberger, Zarixia Zavala-Ruiz, James E. Evans, and Lawrence J. Stern

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Three residues in HIV-1 matrix contribute to protease inhibitor susceptibility and replication capacity, Chris M. Parry, Madhavi Kolli, Richard E. Myers, Patricia A. Cane, Celia A. Schiffer, and Deenan Pillay

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A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice, Linghua Qiu, Jaime A. Rivera-Perez, and Zuoshang Xu

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Yeast one-hybrid assays for gene-centered human gene regulatory network mapping, John S. Reece-Hoyes, A. Rasim Barutcu, Rachel Patton McCord, Jun Seop Jeong, Lizhi Jiang, Andrew Macwilliams, Xinping Yang, Kourosh Salehi-Ashtiani, David E. Hill, Seth Blackshaw, Heng Zhu, Job Dekker, and Albertha J. M. Walhout

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Enhanced yeast one-hybrid assays for high-throughput gene-centered regulatory network mapping, John S. Reece-Hoyes, Alos Diallo, Bryan R. Lajoie, Amanda Kent, Shaleen Shrestha, Sreenath Kadreppa, Colin Pesyna, Job Dekker, Chad L. Myers, and Albertha J. M. Walhout

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Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease, Keith P. Romano, Jennifer M. Laine, Laura M. Deveau, Hong Cao, Francesca Massi, and Celia A. Schiffer

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Chromatin globules: a common motif of higher order chromosome structure, Amartya Sanyal, Davide Bau, Marc A. Marti-Renom, and Job Dekker

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MicroRNA Expression Data Reveals a Signature of Kidney Damage following Ischemia Reperfusion Injury, Michael D. Shapiro, Jessamyn Bagley, Jeff Latz, Jonathan G. Godwin, Xupeng Ge, Stefan G. Tullius, and John Iacomini

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Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity, Steven F. Trueman, Elisabet C. Mandon, and Reid Gilmore

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Integrating atom-based and residue-based scoring functions for protein-protein docking, Thom Vreven, Howook Hwang, and Zhiping Weng

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A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression, Kevin C. Wang, Yul W. Yang, Bo Liu, Amartya Sanyal, Ryan Corces-Zimmerman, Yong Chen, Bryan R. Lajoie, Angeline Protacio, Ryan A. Flynn, Rajnish A. Gupta, Joanna Wysocka, Ming Lei, Job Dekker, Jill A. Helms, and Howard Y. Chang

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A quantitative RNA code for mRNA target selection by the germline fate determinant GLD-1, Jane E. Wright, Dimos Gaidatzis, Mathias Senften, Brian M. Farley, Eric Westhof, Sean P. Ryder, and Rafal Ciosk

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MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression, Jun Xie, Qing Xie, Hongwei Zhang, Stefan L. Ameres, Jui-Hung Hung, Qin Su, Ran He, Xin Mu, Seemin Seher Ahmed, Soyeon Park, Hiroki Kato, Chengjian Li, Christian Mueller, Craig C. Mello, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

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Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells, Ozlem Yildirim, Ruowang Li, Jui-Hung Hung, Poshen B. Chen, Xianjun Dong, Ly-Sha Ee, Zhiping Weng, Oliver J. Rando, and Thomas G. Fazzio

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Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells, Nancy R. Zearfoss, Carina C. Clingman, Brian M. Farley, Lisa M. McCoig, and Sean P. Ryder

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Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains, Zhao Zhang, Jia Xu, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Shengmei Ma, Zhiping Weng, William E. Theurkauf, and Phillip D. Zamore

Publications from 2010

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Molecular Basis for Drug Resistance in HIV-1 Protease, Akbar Ali, Rajintha M. Bandaranayake, Yufeng Cai, Nancy M. King, Madhavi Kolli, Seema Mittal, Jennifer E. Foulkes-Murzycki, Madhavi N. L. Nalam, Ellen A. Nalivaika, Aysegul Ozen, Moses Prabu-Jeyabalan, Kelly Thayer, and Celia A. Schiffer

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Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones, Akbar Ali, G. S. Kiran Kumar Reddy, Madhavi N. L. Nalam, Saima G. Anjum, Hong Cao, Celia A. Schiffer, and Tariq M. Rana

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Riding in silence: a little snowboarding, a lot of small RNAs, Stefan L. Ameres and Ryuya Fukunaga

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Target RNA-directed trimming and tailing of small silencing RNAs, Stefan L. Ameres, Michael D. Horwich, Jui-Hung Hung, Jia Xu, Megha Ghildiyal, Zhiping Weng, and Phillip D. Zamore

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The effect of clade-specific sequence polymorphisms on HIV-1 protease activity and inhibitor resistance pathways, Rajintha M. Bandaranayake, Madhavi Kolli, Nancy M. King, Ellen A. Nalivaika, Annie Heroux, Junko Kakizawa, Wataru Sugiura, and Celia A. Schiffer

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Welcome to Silence, David C. Baulcombe and Phillip D. Zamore

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Decomposing the energetic impact of drug resistant mutations in HIV-1 protease on binding DRV, Yufeng Cai and Celia A. Schiffer

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Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals, Benjamin R. Carone, Lucas Fauquier, Naomi Habib, Jeremy Shea, Caroline E. Hart, Ruowang Li, Christoph Bock, Chengjian Li, Hongcang Gu, Phillip D. Zamore, Alexander Meissner, Zhiping Weng, Hans A. Hofmann, Nir Friedman, and Oliver J. Rando

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A simple method for improving the specificity of anti-methyl histone antibodies, Caroline M. Connor, Iris Cheung, Andrew Simon, Mira Jakovcevski, Zhiping Weng, and Schahram Akbarian

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Acute Modulation of Sugar Transport in Brain Capillary Endothelial Cell Cultures during Activation of the Metabolic Stress Pathway, Anthony J. Cura and Anthony Carruthers

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Specificity and membrane partitioning of Grsp1 signaling complexes with Grp1 family Arf exchange factors, Jonathan P. DiNitto, Meng-Tse Lee, Andrew W. Malaby, and David G. Lambright

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Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence, Candace A. Gilbert, Marie-Claire Daou, Richard P. Moser, and Alonzo H. Ross

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Mutational analysis of the latency-associated nuclear antigen DNA-binding domain of Kaposi's sarcoma-associated herpesvirus reveals structural conservation among gammaherpesvirus origin-binding proteins, Soo-Jin Han, Jianhong Hu, Brian G. Pierce, Zhiping Weng, and Rolf Renne

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Topological frustration in beta alpha-repeat proteins: sequence diversity modulates the conserved folding mechanisms of alpha/beta/alpha sandwich proteins., Ronald D. Hills, Sagar V. Kathuria, Louise A. Wallace, Iain J. Day, Charles L. Brooks, and C. Robert Matthews

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Identification of functional modules that correlate with phenotypic difference: the influence of network topology, Jui-Hung Hung, Troy W. Whitfield, Tun-Hsiang Yang, Zhenjun Hu, Zhiping Weng, and Charles Delisi

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Protein-protein docking benchmark version 4.0, Howook Hwang, Thom Vreven, Joel Janin, and Zhiping Weng

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Performance of ZDOCK and ZRANK in CAPRI rounds 13-19, Howook Hwang, Thom Vreven, Brian G. Pierce, Jui-Hung Hung, and Zhiping Weng

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Disulfide-Reduced ALS Variants of Cu, Zn Superoxide Dismutase Exhibit Increased Populations of Unfolded Species., Can Kayatekin, Jill A. Zitzewitz, and C. Robert Matthews

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Structure and function of nematode RNA-binding proteins, Ebru Kaymak, LiangMeng Wee, and Sean P. Ryder

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RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast, Tae Soo Kim, Chih Long Liu, Moran Yassour, John Holik, Nir Friedman, Stephen Buratowski, and Oliver J. Rando

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Sequence features that drive human promoter function and tissue specificity, Jane M. Landolin, David S. Johnson, Nathan D. Trinklein, Shelley Force Aldred, Catherine Medina, Hennady P. Shulha, Zhiping Weng, and Richard M. Myers

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Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function, Chandrashekara Mallappa, Brian T. Nasipak, Letitiah Etheridge, Elliot J. Androphy, Stephen N. Jones, Charles G. Sagerstrom, Yasuyuki Ohkawa, and Anthony N. Imbalzano

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Optical recognition of converted DNA nucleotides for single-molecule DNA sequencing using nanopore arrays, Ben McNally, Alon Singer, Zhiliang Yu, Yingjie Sun, Zhiping Weng, and Amit Meller

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Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres, Alicia M. Mihaliak, Candace A. Gilbert, Li Li, Marie-Claire Daou, Richard P. Moser, Andrew Reeves, Brent H. Cochran, and Alonzo H. Ross

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Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells, Zarmik Moqtaderi, Jie Wang, Debasish Raha, Robert J. White, Michael Snyder, Zhiping Weng, and Kevin Struhl

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Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance, Madhavi N. L. Nalam, Akbar Ali, Michael D. Altman, G. S. Kiran Kumar Reddy, Sripriya Chellappan, Visvaldas Kairys, Aysegul Ozen, Hong Cao, Michael K. Gilson, Bruce Tidor, Tariq M. Rana, and Celia A. Schiffer

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Rationale for more diverse inhibitors in competition with substrates in HIV-1 protease, Nevra Ozer, Celia A. Schiffer, and Turkan Haliloglu

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Combinations of affinity-enhancing mutations in a T cell receptor reveal highly nonadditive effects within and between complementarity determining regions and chains, Brian G. Pierce, Jaafar N. Haidar, Yong Yu, and Zhiping Weng

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Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding, Keith P. Romano, Akbar Ali, William E. Royer, and Celia A. Schiffer

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Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome, Jay M. Sage, Otto S. Gildemeister, and Kendall L. Knight

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Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces., Shivender Shandilya, Madhavi N. L. Nalam, Ellen A. Nalivaika, Phillip J. Gross, Johnathan C. Valesano, Keisuke Shindo, Ming Li, Mary Munson, William E. Royer, Elena Harjes, Takahide Kono, Hiroshi Matsuo, Reuben S. Harris, Mohan Somasundaran, and Celia A. Schiffer

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Bi-specific MHC heterodimers for characterization of cross-reactive T cells, Zu T. Shen, Michael A. Brehm, Keith A. Daniels, Alexander B. Sigalov, Liisa K. Selin, Raymond M. Welsh, and Lawrence J. Stern