Title

Escherichia coli mutator genes

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Date

3-9-1999

Document Type

Article

Medical Subject Headings

DNA Repair; Escherichia coli; Escherichia coli Infections; *Genes, Bacterial; Humans; *Mutagenesis

Abstract

The isolation and characterization of Escherichia coli mutator genes have led to a better understanding of DNA replication fidelity mechanisms and to the discovery of important DNA repair pathways and their relationship to spontaneous mutagenesis. Mutator strains in a population of cells can be beneficial in that they allow rapid selection of variants during periods of stress, such as drug exposure.

Rights and Permissions

Citation: Trends Microbiol. 1999 Jan;7(1):29-36.

Related Resources

Link to Article in PubMed

PubMed ID

10068995