Escherichia coli mutator genes
Department of Biochemistry and Molecular Pharmacology
Medical Subject Headings
DNA Repair; Escherichia coli; Escherichia coli Infections; *Genes, Bacterial; Humans; *Mutagenesis
The isolation and characterization of Escherichia coli mutator genes have led to a better understanding of DNA replication fidelity mechanisms and to the discovery of important DNA repair pathways and their relationship to spontaneous mutagenesis. Mutator strains in a population of cells can be beneficial in that they allow rapid selection of variants during periods of stress, such as drug exposure.
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Citation: Trends Microbiol. 1999 Jan;7(1):29-36.
Horst, Jens-Peter; Wu, Te-hui; and Marinus, Martin G., "Escherichia coli mutator genes" (1999). Biochemistry and Molecular Pharmacology Publications and Presentations. Paper 47.