The great GATC: DNA methylation in E. coli
Department of Biochemistry and Molecular Pharmacology
Medical Subject Headings
Base Sequence; Chromosomes, Bacterial; DNA Modification Methylases; DNA Replication; DNA, Bacterial; Escherichia coli; Gene Expression Regulation; Methylation
In Escherichia coli the methylation of the adenine in the sequence 5'-GATC-3' is catalysed by the dam gene product, a DNA adenine methylase. We review the proposed roles for this methylation, and the sequence it modifies, in mismatch repair, DNA-protein interaction, gene expression, the initiation of chromosome replication, chromosome segregation, chromosome structure and the occurrence of mutational hotspots.
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Citation: Trends Genet. 1989 May;5(5):139-43.
Barras, Frederic and Marinus, Martin G., "The great GATC: DNA methylation in E. coli" (1989). Biochemistry and Molecular Pharmacology Publications and Presentations. Paper 33.