Title

Correlation of DNA adenine methylase activity with spontaneous mutability in Escherichia coli K-12

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Date

4-1-1984

Document Type

Article

Medical Subject Headings

Bacterial Proteins; DNA Repair; DNA, Bacterial; Escherichia coli; Methyltransferases; *Mutation; Plasmids; Site-Specific DNA-Methyltransferase (Adenine-Specific)

Abstract

Using a multicopy plasmid in which the tac promoter has been placed in front of the dam gene of Escherichia coli K-12, we show that levels of DNA adenine methylase activity are correlated with the spontaneous mutation frequency.

Rights and Permissions

Citation: Gene. 1984 Apr;28(1):123-5.

Related Resources

Link to Article in PubMed

PubMed ID

6376282