RNA processing and export
Department of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute
Medical Subject Headings
Active Transport, Cell Nucleus; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic
Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.
Hocine, Sami; Singer, Robert H.; and Grunwald, David, "RNA processing and export" (2010). Biochemistry and Molecular Pharmacology Publications and Presentations. Paper 169.