Nuclear export dynamics of RNA-protein complexes

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute



Document Type


Medical Subject Headings

Active Transport, Cell Nucleus; Cell Nucleus; Cytoplasm; Humans; Microscopy; Nuclear Pore; RNA; Ribonucleoproteins; Ribosomes


The central dogma of molecular biology - DNA makes RNA makes proteins - is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.


Citation: Grünwald D, Singer RH, Rout M. Nuclear export dynamics of RNA-protein complexes. Nature. 2011 Jul 20;475(7356):333-41. doi: 10.1038/nature10318. Link to article on publisher's site

At the time of publication, David Grünwald was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed