Multiscale dynamics in nucleocytoplasmic transport

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute



Document Type


Medical Subject Headings

*Active Transport, Cell Nucleus; Animals; Biological Transport; Cell Nucleus; Cytoplasm; Eukaryotic Cells; Models, Biological; Nuclear Pore; Nuclear Pore Complex Proteins


The nuclear pore complex (NPC) has long been viewed as a point-like entry and exit channel between the nucleus and the cytoplasm. New data support a different view whereby the complex displays distinct spatial dynamics of variable duration ranging from milliseconds to events spanning the entire cell cycle. Discrete interaction sites outside the central channel become apparent, and transport regulation at these sites seems to be of greater importance than currently thought. Nuclear pore components are highly active outside the NPC or impact the fate of cargo transport away from the nuclear pore. The NPC is a highly dynamic, crowded environment-constantly loaded with cargo while providing selectivity based on unfolded proteins. Taken together, this comprises a new paradigm in how we view import/export dynamics and emphasizes the multiscale nature of NPC-mediated cellular transport.


Citation: Grünwald D, Singer RH. Multiscale dynamics in nucleocytoplasmic transport. Curr Opin Cell Biol. 2012 Feb;24(1):100-6. doi: 10.1016/j.ceb.2011.11.011. Link to article on publisher's site

At the time of publication, David Grünwald was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed