Small RNA-Directed Silencing: The Fly Finds Its Inner Fission Yeast
Department of Biochemistry and Molecular Pharmacology
Medical Subject Headings
RNA, Small Interfering
Several recent studies demonstrate that piRNAs guide Piwi protein to repress transposon transcription in fly ovaries, much as fission yeast use siRNAs to silence repeat sequences. Still mysterious though is how Piwi targets euchromatic transposons for silencing, but not the specialized heterochromatic loci that produce piRNA precursors.
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Citation: Curr Biol. 2013 Apr 22;23(8):R318-20. doi: 10.1016/j.cub.2013.03.033. Link to article on publisher's site
Ge, Daniel Tianfang and Zamore, Phillip D., "Small RNA-Directed Silencing: The Fly Finds Its Inner Fission Yeast" (2013). Biochemistry and Molecular Pharmacology Publications and Presentations. Paper 156.