This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Biochemistry and Molecular Pharmacology.

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Publications from 2015

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Access to care and use of the Internet to search for health information: results from the US National Health Interview Survey, Daniel J. Amante, Timothy P. Hogan, Sherry L. Pagoto, Thomas M. English, and Kate L. Lapane

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Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains, Guang Bai, Iris Cheung, Hennady P. Shulha, Joana E. Coelho, Ping Li, Xianjun Dong, Mira Jakovcevski, Yumei Wang, Anastasia Grigorenko, Yan Jiang, Andrew Hoss, Krupal Patel, Ming Zheng, Evgeny Rogaev, Richard H. Myers, Zhiping Weng, Schahram Akbarian, and Jiang-Fan Chen

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Chromosome Conformation Capture (3C) in Budding Yeast, Jon-Matthew Belton and Job Dekker

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Chromosome Conformation Capture Carbon Copy (5C) in Budding Yeast, Jon-Matthew Belton and Job Dekker

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Hi-C in Budding Yeast, Jon-Matthew Belton and Job Dekker

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Measuring Chromatin Structure in Budding Yeast, Jon-Matthew Belton and Job Dekker

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Randomized ligation control for chromosome conformation capture, Jon-Matthew Belton and Job Dekker

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An enhanced gene targeting toolkit for Drosophila: Golic+, Hui-Min Chen, Ya-ling Huang, Barret D. Pfeiffer, Xiaohao Yao, and Tzumin Lee

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Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs, Min-Te Chou, Bo W. Han, Chiung-Po Hsiao, Phillip D. Zamore, Zhiping Weng, and Jui-Hung Hung

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Condensin-driven remodelling of X chromosome topology during dosage compensation, Emily Crane, Qian Bian, Rachel Patton McCord, Bryan R. Lajoie, Bayly S. Wheeler, Edward J. Ralston, Satoru Uzawa, Job Dekker, and Barbara J. Meyer

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The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis, Marina T. DiStefano, Laura V. Danai, Rachel J. Roth Flach, Anil K. Chawla, David J. Pedersen, Adilson L. Guilherme, and Michael P. Czech

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Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation, Jakob Fuhrmann, Kathleen W. Clancy, and Paul R. Thompson

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Viral infection of engrafted human islets leads to diabetes, Glen R. Gallagher, Michael A. Brehm, Robert W. Finberg, Bruce A. Barton, Leonard D. Shultz, Dale L. Greiner, Rita Bortell, and Jennifer P. Wang

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Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements, Ming Gao, Travis Thomson, T Michael Creed, Shikui Tu, Sudan N. Loganathan, Christina A. Jackson, Patrick McCluskey, Yanyan Lin, Scott E. Collier, Zhiping Weng, Paul Lasko, Melanie D. Ohi, and Alexey L. Arkov

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Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF, Sarah J. Hainer, Weifeng Gu, Benjamin R. Carone, Benjamin D. Landry, Oliver J. Rando, Craig C. Mello, and Thomas G. Fazzio

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Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production, Bo W. Han, Wei Wang, Chengjian Li, Zhiping Weng, and Phillip D. Zamore

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piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing, Bo W. Han, Wei Wang, Phillip D. Zamore, and Zhiping Weng

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An optimized kit-free method for making strand-specific deep sequencing libraries from RNA fragments, Erin E. Heyer, Hakan Ozadam, Emiliano P. Ricci, Can Cenik, and Melissa J. Moore

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Structure-Guided Design of a High Affinity Inhibitor to Human CtBP, Brendan J. Hilbert, Benjamin L. Morris, Keith C. Ellis, Janet L. Paulsen, Celia A. Schiffer, Steven R. Grossman, and William E. Royer

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Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells, Sachi Horibata, Tommy V. Vo, Venkataraman Subramanian, Paul R. Thompson, and Scott A. Coonrod

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miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement, Andrew G. Hoss, Adam Labadorf, Jeanne C. Latourelle, Vinay K. Kartha, Tiffany C. Hadzi, James F. Gusella, Marcy E. MacDonald, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, Jean Paul Vonsattel, and Richard H. Myers

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Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C, Tsung-Han S. Hsieh, Assaf Weiner, Bryan R. Lajoie, Job Dekker, Nir Friedman, and Oliver J. Rando

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Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin, Elizabeth Ing-Simmons, Vlad C. Seitan, Andre J. Faure, Paul Flicek, Thomas Carroll, Job Dekker, Amanda G. Fisher, Boris Lenhard, and Matthias Merkenschlager

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Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation., Huw D. Lewis and Paul R. Thompson

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Multicolor CRISPR labeling of chromosomal loci in human cells, Hanhui Ma, Ardalan Naseri, Pablo Reyes-Gutierrez, Scot A. Wolfe, Shaojie Zhang, and Thoru Pederson

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Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified, Georgi K. Marinov, Jie Wang, Dominik Handler, Barbara J. Wold, Zhiping Weng, Gregory J. Hannon, Alexei A. Aravin, Phillip D. Zamore, Julius Brennecke, and Katalin Fejes Toth

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Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution, Nevra Ozer, Aysegul Ozen, Celia A. Schiffer, and Turkan Haliloglu

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Advancements in the Synthesis and Application of Near-Infrared Imaging Reagents: A Dissertation, Steven M. Pauff

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Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth, Yulian P. Ramirez, Ann C. Mladek, Roger M. Phillips, Mikko Gynther, Jarkko Rautio, Alonzo H. Ross, Richard T. Wheelhouse, and Jann N. Sakaria

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Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress, Zhiji Ren and Victor R. Ambros

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The yeast genome undergoes significant topological reorganization in quiescence, Mark T. Rutledge, Mariano Russo, Jon-Matthew Belton, Job Dekker, and James R. Broach

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Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design, Daniel J. Slade, Pengfei Fang, Christina J. Dreyton, Ying Zhang, Jakob Fuhrmann, Don Rempel, Benjamin D. Bax, Scott A. Coonrod, Huw D. Lewis, Min Guo, Michael L. Gross, and Paul R. Thompson

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Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors., Venkataraman Subramanian, Jason S. Knight, Sangram Parelkar, Lynne Anguish, Scott A. Coonrod, Mariana J. Kaplan, and Paul R. Thompson

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Comparative functional characterization of the CSR-1 22G-RNA pathway in Caenorhabditis nematodes, Shikui Tu, Monica Z. Wu, Jie Wang, Asher D. Cutter, Zhiping Weng, and Julie M. Claycomb

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Condensin promotes the juxtaposition of DNA flanking its loading site in Bacillus subtilis, Xindan Wang, Tung B. L. Le, Bryan R. Lajoie, Job Dekker, Michael T. Laub, and David Z. Rudner

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High-resolution chromatin dynamics during a yeast stress response, Assaf Weiner, Tsung-Han S. Hsieh, Alon Appleboim, Hsiuyi V. Chen, Ayelet Rahat, Ido Amit, Oliver J. Rando, and Nir Friedman

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Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan, Cara M. Weismann, Jennifer Ferreira, Allison M. Keeler, Qin Su, Linghua Qiu, Scott A. Shaffer, Zuoshang Xu, Guangping Gao, and Miguel Sena-Esteves

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Inhibiting protein arginine deiminases has antioxidant consequences., Erin E. Witalison, Xiangli Cui, Anne B. Hofseth, Venkataraman Subramanian, Corey P. Causey, Paul R. Thompson, and Lorne J. Hofseth

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Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation., Erin E. Witalison, Paul R. Thompson, and Lorne J. Hofseth

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Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response, Seungchan Yang, Alexandre Jose Christino Quaresma, Jeffrey A. Nickerson, Karin M. Green, Scott A. Shaffer, Anthony N. Imbalzano, Lori A. Martin-Buley, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein

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Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment, Konstantin B. Zeldovich, Ping Liu, Nicholas Renzette, Matthieu Foll, Serena T. Pham, Sergey V. Venev, Glen R. Gallagher, Daniel N. Bolon, Evelyn A. Kurt-Jones, Jeffrey D. Jensen, Daniel R. Caffrey, Celia A. Schiffer, Timothy F. Kowalik, Jennifer P. Wang, and Robert W. Finberg

Publications from 2014

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High-throughput sequencing analysis of post-liver transplantation HCV E2 glycoprotein evolution in the presence and absence of neutralizing monoclonal antibody, Gregory J. Babcock, Sowmya Iyer, Heidi L. Smith, Yan Wang, Kirk Rowley, Donna M. Ambrosino, Phillip D. Zamore, Brian G. Pierce, Deborah C. Molrine, and Zhiping Weng

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Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease, Yufeng Cai, Wazo Myint, Janet L. Paulsen, Celia A. Schiffer, Rieko Ishima, and Nese Kurt Yilmaz

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High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm, Benjamin R. Carone, Jui-Hung Hung, Sarah J. Hainer, Min-Te Chou, Dawn M. Carone, Zhiping Weng, Thomas G. Fazzio, and Oliver J. Rando

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Post-transcriptional regulation of gene expression in innate immunity, Susan Carpenter, Emiliano P. Ricci, Blandine C. Mercier, Melissa J. Moore, and Katherine A. Fitzgerald

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Switching neuronal state: optimal stimuli revealed using a stochastically-seeded gradient algorithm, Joshua TsuKang Chang and David Paydarfar

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Principles of regulatory information conservation between mouse and human, Yong Cheng, Zhihai Ma, Bong-Hyun Kim, Weisheng Wu, Philip Cayting, Alan P. Boyle, Vasavi Sundaram, Xiaoyun Xing, Nergiz Dogan, Jingjing Li, Ghia Euskirchen, Shin Lin, Yiing Lin, Axel Visel, Trupti Kawli, Xinqiong Yang, Dorrelyn Patacsil, Cheryl A. Keller, Belinda Giardine, Anshul Kundaje, Ting Wang, Len A. Pennacchio, Zhiping Weng, Ross C. Hardison, and Michael P. Snyder

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Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein, Jianbo Chen, David Grünwald, Luca Sardo, Andrea Galli, Sergey Plisov, Olga A Nikolaitchik, De Chen, Stephen Lockett, Daniel R. Larson, Vinay K. Pathak, and Wei-Shau Hu

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Endogenous U2.U5.U6 snRNA complexes in S. pombe are intron lariat spliceosomes, Weijun Chen, Hennady P. Shulha, Ami Ashar-Patel, Jing Yang, Karin M. Green, Charles C. Query, Nicholas R. Rhind, Zhiping Weng, and Melissa J. Moore

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A Feedback Loop Couples Musashi-1 Activity to Omega-9 Fatty Acid Biosynthesis: A PhD Dissertation, Carina C. Clingman

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Two ways to fold the genome during the cell cycle: insights obtained with chromosome conformation capture, Job Dekker

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Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation., Christina J. Dreyton, Erin D. Anderson, Venkataraman Subramanian, Dale L. Boger, and Paul R. Thompson

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Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism, Christina J. Dreyton, Bryan Knuckley, Justin E. Jones, Daniel M. Lewallen, and Paul R. Thompson

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Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity, Nishant Dwivedi, Indira Neeli, Nicolas Schall, Haibao Wan, Dominic M. Desiderio, Elena Csernok, Paul R. Thompson, Hayet Dali, Jean-Paul Briand, Sylviane Muller, and Marko Radic

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Influenza virus drug resistance: a time-sampled population genetics perspective, Matthieu Foll, Yu Ping Poh, Nicholas Renzette, Anna Ferrer Admetlla, Claudia Bank, Hyunjin Shim, Anna Sapfo Malaspinas, Gregory Ewing, Ping Liu, Daniel Wegmann, Daniel R. Caffrey, Konstantin B. Zeldovich, Daniel N. A. Bolon, Jennifer Wang, Timothy F. Kowalik, Celia A. Schiffer, Robert W. Finberg, and Jeffrey D. Jensen

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Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription, Luca Giorgetti, Rafael Galupa, Elphege P. Nora, Tristan Piolot, France Lam, Job Dekker, Guido Tiana, and Edith Heard

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An improved predictive recognition model for Cys2-His2 zinc finger proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J. Keith Joung, Scot A. Wolfe, and Gary D. Stormo

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Backbone flexibility of CDR3 and immune recognition of antigens, Jaafar N. Haidar, Wei Zhu, Jacqueline Lypowy, Brian G. Pierce, Amtul Bari, Kris Persaud, Xenia Luna, Marshall Snavely, Dale Ludwig, and Zhiping Weng

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Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design, Brendan J. Hilbert, Steven R. Grossman, Celia A. Schiffer, and William E. Royer

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Dissecting cis and trans Determinants of Nucleosome Positioning: A Dissertation, Amanda L. Hughes

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Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease, Chien-Min Hung, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Huawei Li, Clary B. Clish, Simone Hettmer, Amy J. Wagers, and David A. Guertin

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Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease, Manolis Kellis, Job Dekker, Zhiping Weng, and Ross C. Hardison

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A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans, Heesun Kim, Takao Ishidate, Krishna S. Ghanta, Meetu Seth, Darryl Conte Jr., Masaki Shirayama, and Craig C. Mello

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Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis., Jason S. Knight, Wei Luo, Alexander A. O'Dell, Srilakshmi Yalavarthi, Wenpu Zhao, Venkataraman Subramanian, Chiao Guo, Robert C. Grenn, Paul R. Thompson, Daniel T. Eitzman, and Mariana J. Kaplan

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Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice., Jason S. Knight, Venkataraman Subramanian, Alexander A. O'Dell, Srilakshmi Yalavarthi, Wenpu Zhao, Carolyne K. Smith, Jeffrey B. Hodgin, Paul R. Thompson, and Mariana J. Kaplan

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HIV-1 protease-substrate coevolution in nelfinavir resistance, Madhavi Kolli, Aysegul Ozen, Nese Kurt Yilmaz, and Celia A. Schiffer

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Hox regulation of transcription: more complex(es), Franck Ladam and Charles G. Sagerstrom

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The Hitchhiker's guide to Hi-C analysis: Practical guidelines, Bryan R. Lajoie, Job Dekker, and Noam Kaplan

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Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates., Sigrun Lange, Eridan Rocha-Ferreira, Laura Thei, Priyanka Mawjee, Kate Bennett, Paul R. Thompson, Venkataraman Subramanian, Anthony P. Nicholas, Donald Peebles, Mariya Hristova, and Gennadij Raivich

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Blind prediction of interfacial water positions in CAPRI, Marc F. Lensink, Iain H. Moal, Paul A. Bates, Panagiotis L. Kastritis, Adrien S.J. Melquiond, Ezgi Karaca, Christophe Schmitz, Marc van Dijk, Alexandre M.J.J. Bonvin, Miriam Eisenstein, Brian G. Pierce, Howook Hwang, Thom Vreven, and Zhiping Weng

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A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs., Daniel M. Lewallen, Kevin L. Bicker, Franck Madoux, Peter Chase, Lynne Anguish, Scott Coonrod, Peter Hodder, and Paul R. Thompson

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Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation, Daniel M. Lewallen, Anju Sreelatha, Venkatasubramanian Dharmarajan, Franck Madoux, Peter Chase, Patrick R. Griffin, Kim Orth, Peter Hodder, and Paul R. Thompson

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An Integrated Structural Mechanism for Relief of Autoinhibition and Membrane Targeting in Cytohesin Family Guanine Nucleotide Exchange Factors: A Dissertation, Andrew W. Malaby

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Identification of Molecular Determinants that Shift Co- and Post-Translational N-Glycosylation Kinetics in Type I Transmembrane Peptides: A Dissertation, Heidi L. H. Malaby

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Angiomotins link F-actin architecture to Hippo pathway signaling, Sebastian Mana-Capelli, Murugan Paramasivam, Shubham Dutta, and Dannel McCollum

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Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme, Benjamin J. Manning and Craig L. Peterson

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Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe, Takeshi Mizuguchi, Geoffrey Fudenberg, Sameet Mehta, Jon-Matthew Belton, Nitika Taneja, Hernan Diego Folco, Peter FitzGerald, Job Dekker, Leonid Mirny, Jemima Barrowman, and Shiv I. S. Grewal

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Calmodulation meta-analysis: Predicting calmodulin binding via canonical motif clustering, Karen Mruk, Brian M. Farley, Alan W. Ritacco, and William R. Kobertz

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Early Folding Biases in the Folding Free-Energy Surface of βα-Repeat Proteins: A Dissertation, Robert P. Nobrega

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Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease, Aysegul Ozen, Kuan-Hung Lin, Nese Kurt Yilmaz, and Celia A. Schiffer

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ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers, Brian G. Pierce, Kevin Wiehe, Howook Hwang, Bong-Hyun Kim, Thom Vreven, and Zhiping Weng

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Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1, Patricia A. Pope, Samyabrata Bhaduri, and Peter M. Pryciak

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Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease, Debra A. Ragland, Ellen A. Nalivaika, Madhavi N. L. Nalam, Kristina L. Prachanronarong, Hong Cao, Rajintha M. Bandaranayake, Yufeng Cai, Nese Kurt Yilmaz, and Celia A. Schiffer

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Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro, Nicholas Renzette, Daniel R. Caffrey, Konstantin B. Zeldovich, Ping Liu, Glen R. Gallagher, Daniel Aiello, Alyssa J. Porter, Evelyn A. Kurt-Jones, Daniel N. Bolon, Yu-Ping Poh, Jeffrey D. Jensen, Celia A. Schiffer, Timothy F. Kowalik, Robert W. Finberg, and Jennifer P. Wang

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Analyses of All Possible Point Mutations within a Protein Reveals Relationships between Function and Experimental Fitness: A Dissertation, Benjamin P. Roscoe

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Putting the Pieces Together: Exons and piRNAs: A Dissertation, Christian K. Roy

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Using unnatural amino acid mutagenesis to probe the regulation of PRMT1., Heather L. Rust, Venkataraman Subramanian, Graham M. West, Douglas D. Young, Peter G. Schultz, and Paul R. Thompson

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A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif, Shivender Shandilya, Markus-Frederik Bohn, and Celia A. Schiffer

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Regulation of histone H3K4 methylation in brain development and disease, Erica Shen, Hennady P. Shulha, Zhiping Weng, and Schahram Akbarian

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A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming., Daniel J. Slade, Sachi Horibata, Scott A. Coonrod, and Paul R. Thompson

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Chemical and biological methods to detect post-translational modifications of arginine., Daniel J. Slade, Venkataraman Subramanian, Jakob Fuhrmann, and Paul R. Thompson

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Pluripotency: citrullination unravels stem cells, Daniel J. Slade, Venkataraman Subramanian, and Paul R. Thompson

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Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus., Carolyne K. Smith, Anuradha Vivekanandan-Giri, Chongren Tang, Jason S. Knight, Anna Mathew, Robin L. Padilla, Brenda W. Gillespie, Carmelo Carmona-Rivera, Xiaodan Liu, Venkataraman Subramanian, Sarfaraz Hasni, Paul R. Thompson, Jay W. Heinecke, Rajiv Saran, Subramaniam Pennathur, and Mariana J. Kaplan

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Structural analysis of asunaprevir resistance in HCV NS3/4A protease, Djade Soumana, Akbar Ali, and Celia A. Schiffer

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Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies, Beatriz Trastoy, Joseph V. Lomino, Brian G. Pierce, Lester G. Carter, Sebastian Gunther, John P. Giddens, Greg A. Snyder, Thomas M. Weiss, Zhiping Weng, Lai-Xi Wang, and Eric J. Sundberg

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Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway., Kin Pong U, Venkataraman Subramanian, Antony P. Nicholas, Paul R. Thompson, and Patrizia Ferretti

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Evaluating template-based and template-free protein-protein complex structure prediction, Thom Vreven, Howook Hwang, Brian G. Pierce, and Zhiping Weng

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Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain, Timothy R. Wagenaar, Leyuan Ma, Benjamin P. Roscoe, Sung Mi Park, Daniel N. Bolon, and Michael R. Green

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Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis, Hongyan Wang, Bin Yang, Linghua Qiu, Chunxing Yang, Joshua Kramer, Qin Su, Yansu Guo, Robert H. Brown Jr., Guangping Gao, and Zuoshang Xu

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Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion., Min Wang, Jakob Fuhrmann, and Paul R. Thompson