Department of Biochemistry and Molecular Pharmacology; Program in Bioinformatics and Integrative Biology
Medical Subject Headings
Genomics; Polymorphism, Single Nucleotide; *Software; Transcription Initiation Site
Bioinformatics | Computational Biology | Systems Biology
We have implemented aggregation and correlation toolbox (ACT), an efficient, multifaceted toolbox for analyzing continuous signal and discrete region tracks from high-throughput genomic experiments, such as RNA-seq or ChIP-chip signal profiles from the ENCODE and modENCODE projects, or lists of single nucleotide polymorphisms from the 1000 genomes project. It is able to generate aggregate profiles of a given track around a set of specified anchor points, such as transcription start sites. It is also able to correlate related tracks and analyze them for saturation--i.e. how much of a certain feature is covered with each new succeeding experiment. The ACT site contains downloadable code in a variety of formats, interactive web servers (for use on small quantities of data), example datasets, documentation and a gallery of outputs. Here, we explain the components of the toolbox in more detail and apply them in various contexts. AVAILABILITY: ACT is available at http://act.gersteinlab.org CONTACT: firstname.lastname@example.org.
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Citation: Bioinformatics. 2011 Apr 15;27(8):1152-4. doi: 10.1093/bioinformatics/btr092. Link to article on publisher's site
Jee, Justin; Rozowsky, Joel; Yip, Kevin Y.; Lochovsky, Lucas; Bjornson, Robert; Zhong, Guoneng; Zhang, Zhengdong; Fu, Yutao; Wang, Jie; Weng, Zhiping; and Gerstein, Mark B., "ACT: aggregation and correlation toolbox for analyses of genome tracks" (2011). Program in Bioinformatics and Integrative Biology Publications and Presentations. Paper 26.