Title

Peak-Finding Algorithms

UMMS Affiliation

Program in Bioinformatics and Integrative Biology; Department of Biochemistry and Molecular Pharmacology

Date

8-29-2016

Document Type

Article

Disciplines

Bioinformatics | Computational Biology

Abstract

Microarray and next-generation sequencing technologies have greatly expedited the discovery of genomic DNA that can be enriched using various biochemical methods. Chromatin immunoprecipitation (ChIP) is a general method for enriching chromatin fragments that are specifically recognized by an antibody. The resulting DNA fragments can be assayed by microarray (ChIP-chip) or sequencing (ChIP-seq). This introduction focuses on ChIP-seq data analysis. The first step of analyzing ChIP-seq data is identifying regions in the genome that are enriched in a ChIP sample; these regions are called peaks.

Rights and Permissions

Citation: Cold Spring Harb Protoc. 2016 Aug 29. doi: 10.1101/pdb.top093179. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

27574196