This collection showcases the journal articles, book chapters, and other publications and presentations written by faculty and researchers of the Department of Anesthesiology at the University of Massachusetts Medical School.

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Publications from 2004

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Frequency of laboratory test utilization in the intensive care unit and its implications for large scale data collection efforts, Joseph J. Frassica

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Tissue pH determination for the detection of metabolically active, inflamed vulnerable plaques using near-infrared spectroscopy: an in-vitro feasibility study, Tania N. Khan, Babs R. Soller, Morteza Naghavi, and Ward Casscells

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Application of flow cytometry to platelet disorders, Matthew Dean Linden, Andrew L. Frelinger III, Marc R. Barnard, Karin Przyklenk, Mark I. Furman, and Alan D. Michelson

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Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4, Leisa Mandell, Anthony P. Moran, Andrew Cocchiarella, JeanMarie Houghton, Nancy Taylor, James G. Fox, Timothy C. Wang, and Evelyn A. Kurt-Jones

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In vitro exposure of bacteria to antimicrobial impregnated-central venous catheters does not directly lead to the emergence of antimicrobial resistance, Erik L. Munson, Stephen O. Heard, and Gary V. Doern

Publications from 2003

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Prevention of descending pneumonia in rts with perflubron-delivered tobramycin, Eric W. Dickson, Gary V. Doern, Leo Trevino, Michelle Mazzoni, and Stephen O. Heard

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Gastric tonometry: the hemodynamic monitor of choice (Pro), Stephen O. Heard

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Correlation between hearing loss and scala media area in guinea pigs with long-standing endolymphatic hydrops, Morgan E. Hott, Martin Graham, Lawrence J. Bonassar, and Cliff A. Megerian

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Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits, Karin Przyklenk, Guohu Li, Boris Z. Simkhovich, and Robert A. Kloner

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Noninvasive, near infrared spectroscopic-measured muscle pH and PO2 indicate tissue perfusion for cardiac surgical patients undergoing cardiopulmonary bypass, Babs R. Soller, Patrick O. Idwasi, Jorge Balaguer, Steven Levin, Sinan A. Simsir, Thomas J. Vander Salm, Helen Collette, and Stephen O. Heard

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Investigation of muscle pH as an indicator of liver pH and injury from hemorrhagic shock, Babs R. Soller, Tania N. Khan, Janice Favreau, Charles Hsi, Juan Carlos Puyana, and Stephen O. Heard

Publications from 2002

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Droperidol: should the black box be light gray, Mark Dershwitz

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Postoperative nausea and vomiting after total intravenous anesthesia with propofol and remifentanil or alfentanil: how important is the opioid, Mark Dershwitz, Piotr Michalowski, YuChiao Chang, Carl E. Rosow, and Lydia A. Conlay

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Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia, Eric W. Dickson, Stephen O. Heard, Thomas E. Tarara, Jeffry G. Weers, Angela B. Brueggemann, and Gary V. Doern

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Myocardial preconditioning factors evoke mesenteric ischemic tolerance via opioid receptors and K(ATP) channels, Eric W. Dickson, Robert J. Tubbs, William A. Porcaro, Won Jae Lee, David J. Blehar, Robert E. Carraway, Chad E. Darling, and Karin Przyklenk

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Septic shock: targeting evaluation and treatment; halting the progression to multiple organ failure, Khaldoun Faris

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Use of meperidine in patient-controlled analgesia and the development of a normeperidine toxic reaction, Thomas T. Simopoulos, Howard S. Smith, Christine Peeters-Asdourian, and Donald S. Stevens

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Effects of a multifaceted, multidisciplinary, hospital-wide quality improvement program on weaning from mechanical ventilation, Nicholas A. Smyrnios, Ann E. Connolly, Mark M. Wilson, Frederick J. Curley, Cynthia T. French, Stephen O. Heard, and Richard S. Irwin

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Delta opiates increase ischemic tolerance in isolated rabbit jejunum, Robert J. Tubbs, William A. Porcaro, Won Jae Lee, David J. Blehar, Robert E. Carraway, Karin Przyklenk, and Eric W. Dickson

Publications from 2001

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Diffusion of nitrous oxide into the pleural cavity, Shubjeet Kaur, Joanquin Cortiella, and Charles A. Vacanti

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Age dependence of cellular properties of human septal cartilage: implications for tissue engineering, Nicole Rotter, Lawrence J. Bonassar, Geoffrey Tobias, Martin Lebl, Amit K. Roy, and Charles A. Vacanti

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Simultaneous measurement of hepatic tissue pH, venous oxygen saturation and hemoglobin by near infrared spectroscopy, Babs R. Soller, Ndumiso A. Cingo, Juan Carlos Puyana, Tania N. Khan, Charles Hsi, H Kim, Janice Favreau, and Stephen O. Heard

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Application of fiberoptic sensors for the study of hepatic dysoxia in swine hemorrhagic shock, Babs R. Soller, Stephen O. Heard, Ndumiso A. Cingo, Charles Hsi, Janice Favreau, Tania N. Khan, Randy R. Ross, and Juan Carlos Puyana

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Tissue-engineered spinal cord, Martin P. Vacanti, Jack L. Leonard, Benjamin Dore, Lawrence J. Bonassar, Yi Lin Cao, Stanley J. Stachelek, Joseph P. Vacanti, F. O√ĘConnell, C. S. Yu, Alan P. Farwell, and Charles A. Vacanti

Publications from 2000

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Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers, Mark Dershwitz, John L. Walsh, Richard J. Morishige, Patricia M. Connors, Reid M. Rubsamen, Steven L. Shafer, and Carl E. Rosow

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Acceptance of an ABO-incompatible mismatched (AB(+) to O(+)) liver allograft with the use of daclizumab and mycophenolate mofetil, W. Christopher Fang, John R. Saltzman, Sarah Rososhansky, Gyongyi Szabo, Stephen O. Heard, Barbara F. Banner, Ravi Chari, and Eliezer Katz

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Identifying a site for maximum delivery of oxygen to transplanted cells, Shubjeet Kaur, Joaquin Cortiella, and Charles A. Vacanti

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Outpatient tympanomastoidectomy: factors affecting hospital admission, Cliff A. Megerian, Jackie Reily, Frank M. O'Connell, and Stephen O. Heard

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The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery, Pekka Talke, Richard Chen, Brian Thomas, Anil Aggarwall, Alexandru Gottlieb, Per Thorborg, Stephen O. Heard, Albert Cheung, Stanley Lee Son, and Antero Kallio

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Investigation of Noninvasive in Vivo Blood Hematocrit Measurement Using NIR Reflectance Spectroscopy and Partial Least-Squares Regression, Songbiao Zhang, Babs R. Soller, Shubjeet Kaur, Kristen Perras, and Thomas J. Vander Salm

Publications from 1999

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Liposomal prostaglandin E1 (TLC C-53) in acute respiratory distress syndrome: a controlled, randomized, double-blind, multicenter clinical trial. TLC C-53 ARDS Study Group, Edward Abraham, Robert Baughman, Eugene Fletcher, Stephen O. Heard, James Lamberti, Howard Levy, Loren Nelson, Mark Rumbak, Jay Steingrub, James Taylor, Youn C. Park, Jeri Matera Hynds, and Jeffrey Freitag

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A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group, Rabih O. Darouiche, Issam I. Raad, Stephen O. Heard, John I. Thornby, Olivier C. Wenker, Andrea Gabrielli, Johannes Berg, Nancy Khardori, Hend Hanna, Ray Hachem, Richard L. Harris, and Glen Mayhall

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The influence of liposome-encapsulated prostaglandin E1 on hydrogen peroxide concentrations in the exhaled breath of patients with the acute respiratory distress syndrome, Stephen O. Heard, Karen J. Longtine, Ildiko Toth, Juan Carlos Puyana, Bruce Potenza, and Nicholas A. Smyrnios

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Characteristics of cartilage engineered from human pediatric auricular cartilage, Angela Rodriguez, Yi Lin Cao, Clemente Ibarra, Stephen Pap, Martin Vacanti, Roland D. Eavey, and Charles A. Vacanti

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Bronchopulmonary segmental lavage with Surfaxin (KL(4)-surfactant) for acute respiratory distress syndrome, Thomas E. Wiswell, Robert M. Smith, Laurence B. Katz, Lisa Mastroianni, Davies Y. Wong, David Willms, Stephen O. Heard, Mark M. Wilson, R. Duncan Hite, Antonio Anzueto, Susan D. Revak, and Charles G. Cochrane

Publications from 1998

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Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia, Eric W. Dickson, Stephen O. Heard, Benson Chu, Armando E. Fraire, Angela B. Brueggemann, and Gary V. Doern

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Effect of prophylactic administration of recombinant human granulocyte colony-stimulating factor (filgrastim) on the frequency of nosocomial infections in patients with acute traumatic brain injury or cerebral hemorrhage. The Filgrastim Study Group, Stephen O. Heard, Mitchell P. Fink, Richard L. Gamelli, Joseph S. Solomkin, Manjari Joshi, Arthur L. Trask, Timothy C. Fabian, Leonard D. Hudson, Kevin B. Gerold, and Eileen D. Logan

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Influence of triple-lumen central venous catheters coated with chlorhexidine and silver sulfadiazine on the incidence of catheter-related bacteremia, Stephen O. Heard, Manisha Wagle, Elamana Vijayakumar, Susan McLean, Angela Brueggemann, Lena M. Napolitano, L. Paul Edwards, Frank M. O'Connell, Juan Carlos Puyana, and Gary V. Doern

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Tracheal bronchus: a cause of prolonged atelectasis in intubated children, Brian P. O'Sullivan, Joseph J. Frassica, and Shawn M. Rayder

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The use of neuromuscular blocking agents in the emergency department to facilitate tracheal intubation in the trauma patient: help or hindrance, Elamana Vijayakumar, Hemmo Bosscher, Francis F. Renzi, Stephen P. Baker, and Stephen O. Heard

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Partial Least-Squares Modeling of Near-Infrared Reflectance Data for Noninvasive in Vivo Determination of Deep-Tissue pH, Songbiao Zhang, Babs R. Soller, and Ronald H. Micheels

Publications from 1997

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Pediatric pheochromocytoma. A 36-year review, S. H. Ein, John Pullerits, R. Creighton, and J. W. Balfe

Publications from 1996

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Third-degree heart block complicating supraclavicular brachial plexus block, Anil Vyas, Frank M. O'Connell, and Charles A. Vacanti

Publications from 1994

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Treatment of severe pneumonia in hospitalized patients: results of a multicenter, randomized, double-blind trial comparing intravenous ciprofloxacin with imipenem-cilastatin. The Severe Pneumonia Study Group, Mitchell P. Fink, David R. Snydman, Michael S. Niederman, Kenneth V. Leeper Jr., Royce H. Johnson, Stephen O. Heard, Richard G. Wunderink, John W. Caldwell, Jerome J. Schentag, and Ghodrat A. Siami

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The role of protein kinase C in lipopolysaccharide-induced myocardial depression in guinea pigs, Stephen O. Heard, Ildiko E. Toth, Michael W. Perkins, and Jack L. Leonard

Publications from 1993

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Use of ultrahigh frequency ventilation in patients with ARDS. A preliminary report, Eric Gluck, Stephen O. Heard, Chandra Patel, David C. Mohr, Jerry Calkins, Mitchell P. Fink, and L. Landow

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Synapsin I gene expression in the adult rat brain with comparative analysis of mRNA and protein in the hippocampus, Richard H. Melloni, Liza M. Hemmendinger, James E. Hamos, and Louis J. DeGennaro

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Pediatric neuraxial blockade, John Pullerits and Robert S. Holzman

Publications from 1992

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Analgesic effect of intraarticular bupivacaine or morphine after arthroscopic knee surgery: a randomized, prospective, double-blind study, Stephen O. Heard, W. Thomas Edwards, Dudley Ferrari, Deborah Hanna, Patricia D. Wong, Astrid Liland, and Marcelle M. Willock

Publications from 1991

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Gastric tonometry in healthy volunteers: effect of ranitidine on calculated intramural pH, Stephen O. Heard, Cathleen M. Helsmoortel, Joel C. Kent, Albert Shahnarian, and Mitchell P. Fink