Use of ultrahigh frequency ventilation in patients with ARDS. A preliminary report
Department of Anesthesiology; Department of Surgery
Medical Subject Headings
Adolescent; Adult; Aged; Female; Hemodynamics; *High-Frequency Jet Ventilation; Humans; Male; Middle Aged; Oxygen; Pressure; Prospective Studies; Pulmonary Ventilation; Respiration, Artificial; Respiratory Distress Syndrome, Adult; Treatment Outcome
STUDY OBJECTIVE: Our objective was to compare the efficacy of ultrahigh frequency ventilation (UHFV) (frequencies > 3 Hz) with respect to oxygenation, airway pressures, and hemodynamic parameters in patients with adult respiratory distress syndrome (ARDS) who were not responding to conventional ventilation.
DESIGN: We used a prospective, multicenter, nonrandomized study design in which each patient served as his own control. SETTING: Three university-affiliated, tertiary-care medical centers participated.
PATIENTS: Persons aged 16 to 79 years old with ARDS and unresponsive to conventional ventilation, as defined by a Food and Drug Administration (FDA) approved protocol, were included.
INTERVENTIONS: Ninety patients who were not responding to conventional ventilation were changed to UHFV using a microcomputer-controlled device.
MEASUREMENTS AND RESULTS: The patient's blood gas, hemodynamic, and airway pressure variables were measured just before, and at 1 and 24 h after the switch to UHFV. We demonstrated clinically significant improvements in arterial oxygen tension (PaO2) and reductions in peak and mean inspiratory pressures.
CONCLUSIONS: In a multicenter study, UHFV improved respiratory gas exchange and reduced airway pressure variables at both 1 h and 24 h after the onset of UHFV when compared with conventional ventilation just prior to the change and without hemodynamic deterioration, in patients with severe ARDS.
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Citation: Chest. 1993 May;103(5):1413-20. DOI 10.1378/chest.103.5.1413
Gluck, Eric; Heard, Stephen O.; Patel, Chandra; Mohr, David C.; Calkins, Jerry; Fink, Mitchell P.; and Landow, L., "Use of ultrahigh frequency ventilation in patients with ARDS. A preliminary report" (1993). Anesthesiology Publications and Presentations. 40.