Title

Tau Splicing and the Intricacies of Dementia

UMMS Affiliation

Department of Cell Biology

Date

3-2012

Document Type

Article

Medical Subject Headings

Alternative Splicing; tau Proteins; Neurodegenerative Diseases

Disciplines

Cell Biology

Abstract

Tau is a microtubule-associated protein that fulfills several functions critical for neuronal formation and health. Tau discharges its functions by producing multiple isoforms via regulated alternative splicing. These isoforms modulate tau function in normal brain by altering the domains of the protein, thereby influencing its localization, conformation, and post-translational modifications and hence its availability and affinity for microtubules and other ligands. Disturbances in tau expression result in disruption of the neuronal cytoskeleton and formation of tau structures (neurofibrillary tangles) found in brains of dementia sufferers. More specifically, aberrations in tau splicing regulation directly cause several neurodegenerative diseases, which lead to dementia. In this review, I present our cumulative knowledge of tau splicing regulation in connection with neurodegeneration and also briefly go over the still-extensive list of questions that are connected to tau (dys)function. J. Cell. Physiol. 227: 1220-1225, 2012. (c) 2011 Wiley Periodicals, Inc.

Rights and Permissions

Citation: J Cell Physiol. 2012 Mar;227(3):1220-5. doi: 10.1002/jcp.22842. Link to article on publisher's site

Related Resources

Link to Article in PubMed