Title
Transcriptional regulation of the mouse microtubule-associated protein tau
UMMS Affiliation
Department of Cell Biology
Date
1-4-2005
Document Type
Article
Medical Subject Headings
Animals; Base Sequence; Gene Expression Regulation; Humans; Mice; Microtubules; Molecular Sequence Data; Promoter Regions, Genetic; Rats; Sequence Alignment; Transcription, Genetic; tau Proteins
Disciplines
Cell Biology
Abstract
The microtubule-associated protein (MAP) tau is found primarily in neurons and errors in its regulation are associated with Alzheimer's disease and other neurodegenerative disorders. Tau expression is transcriptionally regulated and tissue-specific. In this study, starting with a approximately 7500-bp fragment from the mouse tau gene, which includes tau exon -1, we define regions preferentially conferring tissue-specific expression. Furthermore, gel shift assays indicate that transcriptional regulators SP-1 and AP-2 are important for basal expression but not necessary for neuron-specific expression of the tau transcript.
Rights and Permissions
Citation: Biochim Biophys Acta. 2005 Jan 11;1681(2-3):175-81. Epub 2004 Nov 26. Link to article on publisher's site