This collection showcases the journal articles and other publications authored by researchers in the Andreadis Lab in the Department of Cell and Developmental Biology at the University of Massachusetts Medical School.

Submissions from 2012

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Tau Splicing and the Intricacies of Dementia, Athena Andreadis (Journal of cellular physiology)

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Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport, Nicholas M. Kanaan, Gerardo Morfini, Gustavo Pigino, Nichole E. Lapointe, Athena Andreadis, Yuyu Song, Ellen Leitman, Lester I. Binder, and Scott T. Brady (Neurobiology of aging)

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C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1, Chiranthani Sumanasekera, Olga Kelemen, Monique Beullens, Brandon E. Aubol, Joseph A. Adams, Manjula Sunkara, Andrew Morris, Mathieu Bollen, Athena Andreadis, and Stefan Stamm (Nucleic acids research)

Submissions from 2011

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Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases, Nicholas M. Kanaan, Gerardo A. Morfini, Nichole E. Lapointe, Gustavo F. Pigino, Kristina R. Patterson, Yuyu Song, Athena Andreadis, Yifan Fu, Scott T. Brady, and Lester I. Binder (The Journal of neuroscience : the official journal of the Society for Neuroscience)

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Saitohin, which is nested within the tau gene, interacts with tau and Abl and its human-specific allele influences Abl phosphorylation, Yan Wang, Lei Gao, Christopher G. Conrad, and Athena Andreadis (Journal of cellular biochemistry)

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An SRp75/hnRNPG Complex Interacting with hnRNPE2 Regulates the 5' Splice Site of Tau Exon 10, Whose Misregulation Causes Frontotemporal Dementia, Yan Wang, Junning Wang, Lei Gao, Stefan Stamm, and Athena Andreadis (Gene)

Submissions from 2010

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The tempting illusion of genetic virtue, Athena Andreadis (Politics and the life sciences : the journal of the Association for Politics and the Life Sciences)

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DARPP-32 binds to tra2-beta1 and influences alternative splicing, Natalya Benderska, Kristina Becker, Jean-Antoine Girault, Cord-Michael Becker, Athena Andreadis, and Stefan Stamm (Biochimica et biophysica acta)

Submissions from 2009

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Book Review: Current Hypotheses and Research Milestones in Alzheimer's Disease, Athena Andreadis (Journal of Alzheimer's Disease)

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Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro, Nichole E. Lapointe, Peleg M. Horowitz, Angela L. Guillozet-Bongaarts, Andres Silva, Athena Andreadis, and Lester I. Binder (Biochemistry)

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Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations, Yan Wang, Lei Gao, Sze-Wah Tse, and Athena Andreadis (Gene)

Submissions from 2006

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Misregulation of tau alternative splicing in neurodegeneration and dementia, Athena Andreadis (Progress in molecular and subcellular biology)

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SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations, Lei Gao, Junning Wang, Yingzi Wang, and Athena Andreadis (Molecular and cellular neurosciences)

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ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I, Olivier Leroy, Claire-Marie Dhaenens, Suzanna Schraen-Maschke, Karim Belarbi, Andre Delacourte, Athena Andreadis, Bernard Sablonniere, Luc Buee, Nicolas Sergeant, and Marie-Laure Caillet-Boudin (Journal of neuroscience research)

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Brain-specific change in alternative splicing of Tau exon 6 in myotonic dystrophy type 1, Olivier Leroy, Junning Wang, Claude-Alain Maurage, Michel Parent, Thomas Cooper, Luc Buee, Nicolas Sergeant, Athena Andreadis, and Marie-Laure Caillet-Boudin (Biochimica et biophysica acta)

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Tau protects microtubules in the axon from severing by katanin, Liang Qiang, Wenqian Yu, Athena Andreadis, Minhua Luo, and Peter W. Baas (The Journal of neuroscience : the official journal of the Society for Neuroscience)

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Tau exon 6 is regulated by an intricate interplay of trans factors and cis elements, including multiple branch points, Junning Wang, Sze-Wah Tse, and Athena Andreadis (Journal of neurochemistry)

Submissions from 2005

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Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6, Lei Gao, Sze-Wah Tse, Christopher Conrad, and Athena Andreadis (The Journal of biological chemistry)

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Transcriptional regulation of the mouse microtubule-associated protein tau, Lei Gao, Kerry L. Tucker, and Athena Andreadis (Biochimica et biophysica acta)

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The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease, Daniela C. Glatz, Dan Rujescu, Yesheng Tang, Frank J. Berendt, Annette M. Hartmann, Frank Faltraco, Carlyn Rosenberg, Christine Hulette, Kurt Jellinger, Harald Hampel, Peter Riederer, Hans-J Moller, Athena Andreadis, Kerstin Henkel, and Stefan Stamm (Journal of neurochemistry)

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Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cells, Hiromi Nishinaga, Kazuko Takahashi-Niki, Takahiro Taira, Athena Andreadis, Sanai M. M. Iguchi-Ariga, and Hiroyoshi Ariga (Neuroscience letters)

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Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain, Sze-Wah Tse, Jennifer A. Broderick, Mei-Ling Wei, Min-hua Luo, Deborah Smith, Peter J. McCaffery, Stefan Stamm, and Athena Andreadis (Gene)

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Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1, Yingzi Wang, Junning Wang, Lei Gao, Robert Lafyatis, Stefan Stamm, and Athena Andreadis (The Journal of biological chemistry)

Submissions from 2004

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Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases, Athena Andreadis (Biochimica et biophysica acta)